Individual differences in cocaine-induced locomotor activity of male Sprague–Dawley rats are not explained by plasma corticosterone levels

Postpartum depression affects 15% of women.Channa striatus, a freshwater fish, is consumed in local Malay population as a rejuvenating diet during postpartum period. This study evaluated the antidepressant-like effect of lipid extract ofC. striatusfillet and its mechanism of action in female Sprague-Dawley rats in postpartum model of depression. The rats were ovariectomized and treated with high dose of progesterone and estradiol benzoate for 23 days to have hormone-simulated pregnancy. The day 24 and afterwards were considered as the postpartum period. During the postpartum period, lipid extract was administered at 125, 250, and 500 mg/kg through intraperitoneal route for 15 days. Fluoxetine (10 mg/kg) was used as the positive control. On postpartum day 15, the animals were tested in forced swimming test (FST) and open field test (OFT) followed by biochemical analysis. Withdrawal of hormone administration during the postpartum period induced depressive-like behavior in FST. Administration of lipid extract reversed that depressive-like behavior at 125, 250, and 500 mg/kg in FST. In OFT, it decreased the exploratory activity. The mechanism of the antidepressant-like effect may be mediated through the decrease in plasma corticosterone, increase in plasma oxytocin, and decrease in nuclear factor-kappa B in prefrontal cortex of rats.

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CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00365.2011 ◽

2012 ◽

Vol 303 (8) ◽

pp. R850-R860 ◽

Cited By ~ 13

Author(s):

Miriam Goebel-Stengel ◽

Andreas Stengel ◽

Lixin Wang ◽

Gordon Ohning ◽

Yvette Taché ◽

...

Keyword(s):

Locomotor Activity ◽

Food Intake ◽

Molecular Forms ◽

Reduce Food Intake ◽

Dark Phase ◽

Sprague Dawley ◽

Solid Meal ◽

Sprague Dawley Rats ◽

And Behavior

Various molecular forms of CCK reduce food intake in rats. Although CCK-8 is the most studied form, we reported that CCK-58 is the only detectable endocrine peptide form in rats. We investigated the dark-phase rat chow intake pattern following injection of CCK-8 and CCK-58. Ad libitum-fed male Sprague-Dawley rats were intraperitoneally injected with CCK-8, CCK-58 (0.6, 1.8, and 5.2 nmol/kg), or vehicle. Food intake pattern was assessed during the dark phase using an automated weighing system that allowed continuous undisturbed monitoring of physiological eating behavior. Both CCK-8 and CCK-58 dose dependently reduced 1-h, dark-phase food intake, with an equimolar dose of 1.8 nmol being similarly effective (−49% and −44%). CCK-58 increased the latency to the first meal, whereas CCK-8 did not. The intermeal interval was reduced after CCK-8 (1.8 nmol/kg, −41%) but not after CCK-58. At this dose, CCK-8 increased the satiety ratio by 80% and CCK-58 by 160%, respectively, compared with vehicle. When behavior was assessed manually, CCK-8 reduced locomotor activity (−31%), whereas grooming behavior was increased (+59%). CCK-58 affected neither grooming nor locomotor activity. In conclusion, reduction of food intake by CCK-8 and CCK-58 is achieved by differential modulation of food intake microstructure and behavior. These data highlight the importance of studying the molecular forms of peptides that exist in vivo in tissue and circulation of the animal being studied.

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Effects of Aging and D-Glucose on Locomotor Activity, Spontaneous Alternation, and Plasma Glucose Levels in Preweanling Sprague-Dawley Rats

Developmental Neuroscience ◽

10.1159/000091918 ◽

2006 ◽

Vol 28 (3) ◽

pp. 209-215 ◽

Cited By ~ 1

Author(s):

Robert W. Flint Jr. ◽

Dominick Papandrea Jr. ◽

Nancy Dorr

Keyword(s):

Locomotor Activity ◽

Plasma Glucose ◽

Spontaneous Alternation ◽

Sprague Dawley ◽

Glucose Levels ◽

Sprague Dawley Rats ◽

Effects Of Aging

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Lactation alters the effects of conditioned stress on immune function

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1997.272.1.r16 ◽

1997 ◽

Vol 272 (1) ◽

pp. R16-R25 ◽

Cited By ~ 7

Author(s):

N. Shanks ◽

A. Kusnecov ◽

M. Pezzone ◽

J. Berkun ◽

B. S. Rabin

Keyword(s):

Immune Function ◽

Stress Responses ◽

Lymphocyte Proliferation ◽

Physiological State ◽

Cell Receptor ◽

Plasma Corticosterone ◽

Endocrine Function ◽

Nitrite Accumulation ◽

Sprague Dawley ◽

Sprague Dawley Rats

During lactation, endocrine function is altered and stress responses are dampened. Stress effects on immune function are partially determined by endocrine factors; therefore, we assessed whether stress similarly alters immune function during lactation. Sprague-Dawley rats were conditioned by exposure to a tone paired with foot shock (2 sessions, 16 shocks each) prior to breeding or were left undisturbed. Lactating (day 10) (Lac) and nonlactating diestrous virgin controls (C) were killed immediately after reexposure to the tone or removal from their home cage. Plasma corticosterone stress responses were dampened in Lac relative to C animals. Peripheral blood lymphocyte proliferation to T cell receptor antibody stimulation was reduced to a similar extent in both experimental groups. Conditioned stress reduced splenocyte proliferation and increased nitrite accumulation in C animals, but not in Lac animals. Mesenteric lymph node lymphocyte proliferation was significantly increased after stress in Lac compared with C animals. Both plasma interleukin-6 (IL-6) and phytohemagglutinin-stimulated splenic IL-6 production were increased in Lac animals compared with C animals after stress exposure. These data indicate that stress-induced alterations may be determined by different regulatory mechanisms within immune compartments and that these effects depend on the physiological state of the organism.

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Influence of protein deficiency in rats on hormonal status and cytoplasmic glucocorticoid receptors in maternal and fetal tissues

Journal of Endocrinology ◽

10.1677/joe.0.0950049 ◽

1982 ◽

Vol 95 (1) ◽

pp. 49-58 ◽

Cited By ~ 21

Author(s):

S. Mulay ◽

D. R. Varma ◽

S. Solomon

Keyword(s):

Glucocorticoid Receptors ◽

Fetal Liver ◽

Fetal Lung ◽

Maternal Plasma ◽

Plasma Corticosterone ◽

Protein Deficiency ◽

Sprague Dawley ◽

Pregnant Rats ◽

Maternal Malnutrition ◽

Sprague Dawley Rats

The influence of dietary protein deficiency on maternal plasma corticosterone and progesterone levels as well as on maternal and fetal liver and lung cytoplasmic glucocorti-coid receptors has been studied in Sprague–Dawley rats during the last 3 days of gestation. Plasma corticosterone levels of control but not protein-deficient rats increased on days 20 and 21 of gestation; corticosterone levels of protein-deficient rats decreased on day 21 of gestation. Maternal adrenalectomy caused only a moderate decrease in corticosterone levels in both groups of pregnant rats. Fetal corticosterone levels of the two groups of rats were similar. Progesterone levels were consistently lower in protein-deficient than in control animals from day 20 of gestation until 2–12 h after parturition. There were no differences in the binding of [3H]dexamethasone to liver cytosol of non-pregnant control and protein-deficient rats. However, receptor levels were lower in pregnant controls than in pregnant protein-deficient rats. Maternal protein deficiency led to an increase in fetal liver glucocorticoid receptor levels but exerted no significant effect on receptor levels in fetal lung. It is suggested that lower levels of plasma corticosterone and progesterone and high levels of liver glucocorticoid receptors in protein-deficient rats might be related to some of the adverse consequences of maternal malnutrition on fetal development.

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Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague–Dawley rats

Pharmacology Biochemistry and Behavior ◽

10.1016/j.pbb.2011.06.002 ◽

2011 ◽

Vol 99 (4) ◽

pp. 634-638 ◽

Cited By ~ 17

Author(s):

Wei-li Chang ◽

Michelle R. Breier ◽

Alex Yang ◽

Neal R. Swerdlow

Keyword(s):

Locomotor Activity ◽

Sensorimotor Gating ◽

Sprague Dawley ◽

Sprague Dawley Rats

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NAFLD Aggravates Septic Shock Due to Inadequate Adrenal Response and 11β-HSDs Dysregulation in Rats

Pharmaceutics ◽

10.3390/pharmaceutics12050403 ◽

2020 ◽

Vol 12 (5) ◽

pp. 403

Author(s):

Hui-Chun Huang ◽

Ming-Hung Tsai ◽

Fa-Yauh Lee ◽

Te-Yueh Lin ◽

Ching-Chih Chang ◽

...

Keyword(s):

Septic Shock ◽

Plasma Corticosterone ◽

Adrenal Function ◽

Chow Diet ◽

Sprague Dawley ◽

Alcoholic Fatty Liver ◽

Sprague Dawley Rats ◽

Diet Control ◽

Corticosterone Response ◽

Adrenal Response

Background: Non-alcoholic fatty liver disease (NAFLD) is linked with metabolic syndrome. Previous studies showed that obesity may disrupt adrenal function and adversely affect its counter-regulations against shock. This study hence evaluated adrenal function abnormalities in NAFLD with shock. Methods: Sprague-Dawley rats were fed with regular chow-diet (control) or high fat diet (HFD, 60% energy derived from fat). Blood tests were performed at the end of the 4th, 6th and 8th week, respectively. Experiments were performed at the end of the 8th week. Results: HFD rats developed NAFLD. HFD rats had 27% and 51% increase in plasma corticosterone at the 6th and 8th week in usual status. However, HFD rats had 5 times more reduction of mean arterial pressure in response to lipopolysaccharide-induced sepsis as compared to control rats. The corticosterone increment ratio was also lower in HFD rats, even after ACTH administration. 11β-HSD system tended to generate more corticosterone in HFD rats under hemodynamic stable status without shock and the trend was lost in HFD rats with septic shock. Conclusion: Rats with NAFLD had profound septic shock due to inadequate corticosterone response. This is, at least partly, due to 11β-HSDs dysregulation in sepsis.

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