Risk factors for calcification of the vertebrobasilar arteries in cardiovascular patients referred for a head CT, the SMART study

2020 ◽  
Author(s):  
Tim C. van den Beukel ◽  
Carlo Lucci ◽  
Jeroen Hendrikse ◽  
Wilko Spiering ◽  
Huiberdina L. Koek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Head Ct ◽  
Smart Study ◽  
Cardiovascular Patients

Cardiovascular Disorders in Autoimmune Disease

2019 ◽  
Vol 2 (2) ◽  
pp. 01-04
Author(s):  
Delcio G Silva Junior
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cardiovascular Events ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Cardiovascular Patients ◽  
Cardio Vascular Disease ◽  
Traditional Risk Factors ◽  
Cardio Vascular

The presence of Cardio Vascular Disease (CVD) impacts negatively on expectation and quality of life of the population, being one of the main causes of disability. Many of those who become cardiovascular patients throughout their life could have had different evolution if preventive attitudes were taken. Since 50’s decade, Framingham studies have shown the importance of predetermining factors for CVD occurrence. The classical CVD risk factors such as diabetes, metabolic syndrome, dyslipidemia, hypertension, smoking and family history are well established as predictors of cardiovascular events. The presence of Cardio Vascular Disease (CVD) impacts negatively on expectation and quality of life of the population, being one of the main causes of disability. Many of those who become cardiovascular patients throughout their life could have had different evolution if preventive attitudes were taken. Since 50’s decade, Framingham studies have shown the importance of predetermining factors for CVD occurrence. The classical CVD risk factors such as diabetes, metabolic syndrome, dyslipidemia, hypertension, smoking and family history are well established as predictors of cardiovascular events. However, in certain clinical conditions, traditional risk factors seem not to fully explain the incidence of CVD. Coronary artery disease and early atherosclerosis in young women with Systemic Lupus Erythematosus (SLE) are one of the best examples of how chronic inflammatory diseases can affect individuals who are normally poorly exposed to traditional risk factors. Even with the plurality of extra-articular manifestations of rheumatologic diseases, such as pulmonary hypertension and SLE encephalopathy, uveitis in spondyloarthritis, or as Achalasia in scleroderma, attention is being paid to the frequent cardiovascular system involvement in these patients, especially in the vascular territory

scholarly journals Clinical Predictors of 3- and 6-Month Outcome for Mild Traumatic Brain Injury Patients with a Negative Head CT Scan in the Emergency Department: A TRACK-TBI Pilot Study

2020 ◽  
Vol 10 (5) ◽  
pp. 269
Author(s):  
Debbie Madhok ◽  
John Yue ◽  
Xiaoying Sun ◽  
Catherine Suen ◽  
Nathan Coss ◽  
...  
Keyword(s):  
Risk Factors ◽  
Traumatic Brain Injury ◽  
Emergency Department ◽  
Brain Injury ◽  
Pilot Study ◽  
Mild Traumatic Brain Injury ◽  
Psychiatric History ◽  
Clinical Predictors ◽  
Head Ct ◽  
Risk Patients

A considerable subset of mild traumatic brain injury (mTBI) patients fail to return to baseline functional status at or beyond 3 months postinjury. Identifying at-risk patients for poor outcome in the emergency department (ED) may improve surveillance strategies and referral to care. Subjects with mTBI (Glasgow Coma Scale 13–15) and negative ED initial head CT < 24 h of injury, completing 3- or 6-month functional outcome (Glasgow Outcome Scale-Extended; GOSE), were extracted from the prospective, multicenter Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot study. Outcomes were dichotomized to full recovery (GOSE = 8) vs. functional deficits (GOSE < 8). Univariate predictors with p < 0.10 were considered for multivariable regression. Adjusted odds ratios (AOR) were reported for outcome predictors. Significance was assessed at p < 0.05. Subjects who completed GOSE at 3- and 6-month were 211 (GOSE < 8: 60%) and 185 (GOSE < 8: 65%). Risk factors for 6-month GOSE < 8 included less education (AOR = 0.85 per-year increase, 95% CI: (0.74–0.98)), prior psychiatric history (AOR = 3.75 (1.73–8.12)), Asian/minority race (American Indian/Alaskan/Hawaiian/Pacific Islander) (AOR = 23.99 (2.93–196.84)), and Hispanic ethnicity (AOR = 3.48 (1.29–9.37)). Risk factors for 3-month GOSE < 8 were similar with the addition of injury by assault predicting poorer outcome (AOR = 3.53 (1.17–10.63)). In mTBI patients seen in urban trauma center EDs with negative CT, education, injury by assault, Asian/minority race, and prior psychiatric history emerged as risk factors for prolonged disability.

Abstract 14731: Glyc A, a Novel Marker of Inflammation, Predicts Cardiovascular Events in HIV-Positive Patients: Results of SMART Study

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Daniel Duprez ◽  
Jacqueline Neuhaus ◽  
James Otvos ◽  
James D Neaton ◽  
Jens D Lundgren
Keyword(s):  
Risk Factors ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Lipid Lowering ◽  
Hiv Positive ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Hiv Patients ◽  
Smart Study ◽  
Increased Risk

Background: Cardiovascular disease (CVD) is increasing in HIV-infected patients. Glyc A is a novel nuclear magnetic resonance (NMR) spectroscopy signal in plasma arising from the glycosylation of circulating acute phase proteins. The acute phase proteins have been independently associated with CVD in HIV patients, but the association of Glyc A and CVD has not been studied. We aimed to quantify the risk of CVD associated with Glyc A at baseline in HIV-positive patients enrolled in the Strategies for Management of Anti-Retroviral Therapy (SMART) study. Methods: In a nested case-control study, Glyc A was measured using NMR at baseline in 246 HIV positive patients [median age, interquartile range (IQR): 49 (44,56) years, 81 % male], who experienced a CVD event (defined as coronary heart disease (CHD), myocardial infarction, coronary artery disease requiring revascularization, atherosclerotic non-CHD (stroke and peripheral arterial disease), congestive heart failure and CVD or unwitnessed death) over an average of 2.8 years of follow-up and 472 matched controls. Odds ratios (ORs) associated with baseline levels of Glyc A for CVD were estimated using conditional logistic regression unadjusted and after adjustment for BMI, race, HIV-RNA and antiretroviral therapy status, smoking, prior CVD, diabetes, total/high-density lipoprotein cholesterol ratio, use of blood pressure and lipid-lowering drugs, hepatitis co-infection, CD4+ and major baseline ECG abnormalities. Results: At baseline median Glyc A (IQR) was 383 (333, 442) μmol/L in patients who developed a CVD event and 368 (322, 419) μmol/L in controls (P < 0.001 for difference). The unadjusted OR for CVD (highest versus lowest quartile) was 2.18 (with 95% confidence interval (CI) 1.38-3.44, P < 0.001). After adjustment for baseline covariates and CVD risk factors, OR was 2.20 (95% CI, 1.29-3.76, P = 0.004). Conclusion: Higher levels of Glyc A are associated with increased risk of CVD in HIV patients after considering established CVD risk factors.

Acute Traumatic Intraparenchymal Hemorrhage: Risk Factors for Progression in the Early Post-injury Period

Neurosurgery ◽  
2006 ◽  
Vol 58 (4) ◽  
pp. 647-656 ◽  
Author(s):  
Edward F. Chang ◽  
Michele Meeker ◽  
Martin C. Holland
Keyword(s):  
Risk Factors ◽  
Subarachnoid Hemorrhage ◽  
Ct Scan ◽  
Subdural Hematoma ◽  
Outcome Variable ◽  
Trauma Patients ◽  
Post Injury ◽  
Initial Size ◽  
Head Ct ◽  
Surgical Evacuation

Abstract OBJECTIVE: To characterize the natural course of traumatic intraparenchymal contusions and hematomas (IPHs) and to identify risk factors for IPH progression in the acute post-injury period. METHODS: A retrospective analysis was performed on a prospective observational database containing 113 head trauma patients exhibiting 229 initially nonoperated acute IPHs. The main outcome variable was radiographic evidence of IPH progression on serially obtained head computed tomographic (CT) scans. Secondary outcomes included the actual amount of IPH growth and later surgical evacuation. Univariate and multivariate analyses (using a generalized estimate equation) were applied to both demographic and initial radiographic features to identify risk factors for IPH progression and surgery. RESULTS: Overall, 10 IPHs (4%) shrank, 133 (58%) remained unchanged, and 86 (38%) grew between the first and second head CT scan. IPH progression was independently associated with the presence of subarachnoid hemorrhage (odds ratio [OR], 1.6; 95% confidence interval [CI], 1.12–2.3), presence of a subdural hematoma (OR, 1.94; 95% CI, 1.1–3.43), and initial size (OR, 1.11; 95% CI, 1.02–1.21, for each cm3 volume). Size of initial IPH proportionately correlated with the amount of subsequent growth (linear regression, P &lt; 0.001). Worsened Glasgow Coma Score between initial and follow-up head CT scan (OR, 8.6; 95% CI, 1.5–50), IPH growth greater than 5 cm3 (OR, 7.3; 95% CI, 1.6–34), and effacement of basal cisterns on initial CT scan (OR, 9.0; 95% CI, 1.5–52) were strongly associated with late surgical evacuation. CONCLUSION: A large proportion of IPHs progress in the acute post-injury period. IPHs associated with subarachnoid hemorrhage, a subdural hematoma, or large initial size should be monitored carefully for progression with repeat head CT imaging. Effacement of cisterns on the initial head CT scan was strongly predictive of failure of nonoperative management, thereby leading to surgical evacuation. These findings should be important factors in the understanding and management of IPH.

scholarly journals Evaluation Of Risk Factors In Cardiovascular Patients With Diagnosis Of Systemic Lupus Erythematosus (SLE)

10.3823/2590 ◽  
2018 ◽  
Vol 11 ◽  
Author(s):  
Edienny Augusta Tocantins Viana Lobato ◽  
Fernanda Araújo Santos ◽  
Ana Rachel Koury Marinho ◽  
Alvaro Alves Dos Santos Neto ◽  
Suzana Maria Klautau Ferreira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Lupus Erythematosus ◽  
Systemic Hypertension ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Specific Protocol ◽  
Cardiovascular Patients

Title: Evaluation of risk factors in cardiovascular patients with diagnosis of Systemic Lupus Erythematosus (SLE). Background: prevalence of cardiovascular risk factors in lupic patients.This study aimed to evaluate the presence of cardiovascular risk factors in patients diagnosed with SLE in a Rheumatology Ambulatory, comparing groups with and without SLE nephritis. Methods: a quantitative, observational and cross-sectional study was carried out during the period from November 2016 to June 2017. 86 patients were interviewed using specific protocol. Conclusions: among the cardiovascular risk factors evaluated, systemic hypertension was more frequent in SLE patients (33.7%), followed by smoking (17.4%) and diabetes mellitus (5.8%). There was, however, no difference between the frequency of these comorbidities in the groups with and without lupus nephritis.

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