scholarly journals Orphan GPCRs and Neuromodulation

Neuron ◽  
2012 ◽  
Vol 76 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Olivier Civelli
Keyword(s):  
Orphan Gpcrs

scholarly journals The therapeutic potential of orphan GPCRs, GPR35 and GPR55

2015 ◽  
Vol 6 ◽  
Author(s):  
Derek M. Shore ◽  
Patricia H. Reggio
Keyword(s):  
Therapeutic Potential ◽  
Orphan Gpcrs

scholarly journals Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Aliza T. Ehrlich ◽  
Grégoire Maroteaux ◽  
Anne Robe ◽  
Lydie Venteo ◽  
Md. Taufiq Nasseef ◽  
...  
Keyword(s):  
Orphan Gpcrs

Alternative drug discovery approaches for orphan GPCRs

2008 ◽  
Vol 13 (1-2) ◽  
pp. 52-58 ◽  
Author(s):  
A LEVOYE
Keyword(s):  
Drug Discovery ◽  
Alternative Drug ◽  
Orphan Gpcrs

scholarly journals Advancements in therapeutically targeting orphan GPCRs

2015 ◽  
Vol 6 ◽  
Author(s):  
Jennifer A. Stockert ◽  
Lakshmi A. Devi
Keyword(s):  
Orphan Gpcrs

scholarly journals Orphan endogenous lipids and orphan GPCRs: A good match

2009 ◽  
Vol 89 (3-4) ◽  
pp. 131-134 ◽  
Author(s):  
Heather B. Bradshaw ◽  
Sung Ha Lee ◽  
Douglas McHugh
Keyword(s):  
Good Match ◽  
Orphan Gpcrs ◽  
Endogenous Lipids

scholarly journals Evidence for an interaction between proinsulin C-peptide and GPR146

2013 ◽  
Vol 218 (2) ◽  
pp. B1-B8 ◽  
Author(s):  
Gina L C Yosten ◽  
Grant R Kolar ◽  
Lauren J Redlinger ◽  
Willis K Samson
Keyword(s):  
Microvascular Dysfunction ◽  
Protective Role ◽  
Treatment Modalities ◽  
C Peptide ◽  
Signaling Complex ◽  
Peptide Signaling ◽  
Attractive Therapeutic Target ◽  
Matching Strategy ◽  
Orphan Gpcrs ◽  
G Protein Coupled

Microvascular diseases, such as retinopathies, neuropathies, and nephropathies, are a devastating consequence of type 1 and type 2 diabetes. The etiology of diabetes-associated microvascular dysfunction is poorly understood, and, likewise, treatment modalities for these disorders are limited. Interestingly, proinsulin C-peptide has been shown to play a protective role against diabetes-associated complications in experimental animals and in diabetic humans and is thus an attractive therapeutic target. However, an important step in the development of C-peptide-based therapeutics is identification of the C-peptide receptor, which is likely a G protein-coupled receptor (GPCR). Using a unique Deductive Ligand-Receptor Matching Strategy, we sought to determine whether one of the known orphan GPCRs is essential for C-peptide signaling. Knockdown of GPR146, but not GPR107 or GPR160, blocked C-peptide-induced cFos expression in KATOIII cells. Furthermore, stimulation with C-peptide caused internalization of GPR146, and examples of punctate colocalization were observed between C-peptide and GPR146 on KATOIII cell membranes. These data indicate that GPR146 is likely a part of the C-peptide signaling complex and provide a platform for the elucidation of the C-peptide signalosome.

scholarly journals Class A Orphans (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (5) ◽  
Author(s):  
Stephen P.H. Alexander ◽  
Jim Battey ◽  
Helen E. Benson ◽  
Richard V. Benya ◽  
Tom I. Bonner ◽  
...  
Keyword(s):  
Preliminary Evidence ◽  
Endogenous Ligand ◽  
Orphan Receptors ◽  
Endogenous Ligands ◽  
Class A ◽  
Potential Link ◽  
Endogenous Cannabinoid ◽  
Orphan Gpcrs

Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [194], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have recently been reviewed in detail [150]. The GPCRs in Table 1 are all Class A, rhodopsin-like GPCRs. Class A orphan GPCRs not listed in Table 1 are putative GPCRs with as-yet unidentified endogenous ligands.Table 1: Class A orphan GPCRs with putative endogenous ligands GPR3GPR4GPR6GPR12GPR15GPR17GPR20 GPR22GPR26GPR31GPR34GPR35GPR37GPR39 GPR50GPR63GRP65GPR68GPR75GPR84GPR87 GPR88GPR132GPR149GPR161GPR183LGR4LGR5 LGR6MAS1MRGPRDMRGPRX1MRGPRX2P2RY10TAAR2 In addition the orphan receptors GPR18, GPR55 and GPR119 which are reported to respond to endogenous agents analogous to the endogenous cannabinoid ligands have been grouped together (GPR18, GPR55 and GPR119).

scholarly journals High throughput screening at novel striatum orphan GPCRs identified by human transcriptomic profiling

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Daniel Eric Felsing ◽  
Sweta Raval ◽  
Manish Jain ◽  
Simon Xi ◽  
John A Allen
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Transcriptomic Profiling ◽  
Orphan Gpcrs
Sign in / Sign up

Export Citation Format

Share Document