scholarly journals Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation

Neuron ◽  
2021 ◽  
Author(s):  
Clayton P. Mosher ◽  
Adam N. Mamelak ◽  
Mahsa Malekmohammadi ◽  
Nader Pouratian ◽  
Ueli Rutishauser
2020 ◽  
Author(s):  
Clayton P. Mosher ◽  
Adam N. Mamelak ◽  
Mahsa Malekmohammadi ◽  
Nader Pouratian ◽  
Ueli Rutishauser

AbstractThe subthalamic nucleus (STN) supports action selection by inhibiting all motor programs except the desired one. Recent evidence suggests that STN can also cancel an already selected action when goals change, a key aspect of cognitive control. However, there is little neurophysiological evidence for a dissociation between selecting and cancelling actions in the human STN. We recorded single neurons in the STN of humans performing a stop-signal task. Movement-related neurons suppressed their activity during successful stopping whereas stop-signal neurons activated at low-latencies regardless of behavioral outcome. In contrast, STN and motor-cortical beta-bursting occurred only later in the stopping process. Task-related neuronal properties varied by recording location from dorsolateral movement to ventromedial stop-signal tuning. Therefore, action selection and cancellation coexist in STN but are anatomically segregated. These results show that human ventromedial STN neurons carry fast stop-related signals suitable for implementing cognitive control.


Author(s):  
Lidia K Simanjuntak ◽  
Tessa Y M Sihite ◽  
Mesran Mesran ◽  
Nuning Kurniasih ◽  
Yuhandri Yuhandri

All colleges each year organize the selection of new admissions. Acceptance of prospective students in universities as education providers is done by selecting prospective students based on achievement in school and college entrance selection. To select the best student candidates based on predetermined criteria, then use Multi-Criteria Decision Making (MCDM) or commonly called decision support system. One method in MCDM is the Elimination Et Choix Traduisant la Reality (ELECTRE). The ELECTRE method is the best method of action selection. The ELECTRE method to obtain the best alternative by eliminating alternative that do not fit the criteria and can be applied to the decision SNMPTN invitation path.


Author(s):  
Bernhard Hommel

AbstractCommonsense and theorizing about action control agree in assuming that human behavior is (mainly) driven by goals, but no mechanistic theory of what goals are, where they come from, and how they impact action selection is available. Here I develop such a theory that is based on the assumption that GOALs guide Intentional Actions THrough criteria (GOALIATH). The theory is intended to be minimalist and parsimonious with respect to its assumptions, as transparent and mechanistic as possible, and it is based on representational assumptions provided by the Theory of Event Coding (TEC). It holds that goal-directed behavior is guided by selection criteria that activate and create competition between event files that contain action-effect codes matching one or more of the criteria—a competition that eventually settles into a solution favoring the best-matching event file. The criteria are associated with various sources, including biological drives, acquired needs (e.g., of achievement, power, or affiliation), and short-term, sometimes arbitrary, instructed aims. Action selection is, thus, a compromise that tries to satisfy various criteria related to different driving forces, which are also likely to vary in strength over time. Hence, what looks like goal-directed action emerges from, and represents an attempt to satisfy multiple constraints with different origins, purposes, operational characteristics, and timescales—which among other things does not guarantee a high degree of coherence or rationality of the eventual outcome. GOALIATH calls for a radical break with conventional theorizing about the control of goal-directed behavior, as it among other things questions existing cognitive-control theories and dual-route models of action control.


2008 ◽  
Vol 27 (2) ◽  
pp. 286-295 ◽  
Author(s):  
Lewis Pettit ◽  
Jennifer Charles ◽  
Andrew D. Wilson ◽  
Mandy S. Plumb ◽  
Anne Brockman ◽  
...  

2009 ◽  
Vol 102 (4) ◽  
pp. 2526-2537 ◽  
Author(s):  
Sylvie Lardeux ◽  
Remy Pernaud ◽  
Dany Paleressompoulle ◽  
Christelle Baunez

It was recently shown that subthalamic nucleus (STN) lesions affect motivation for food, cocaine, and alcohol, differentially, according to either the nature of the reward or the preference for it. The STN may thus code a reward according to its value. Here, we investigated how the firing of subthalamic neurons is modulated during expectation of a predicted reward between two possibilities (4 or 32% sucrose solution). The firing pattern of neurons responding to predictive cues and to reward delivery indicates that STN neurons can be divided into subpopulations responding specifically to one reward and less or giving no response to the other. In addition, some neurons (“oops” neurons) specifically encode errors as they respond only during error trials. These results reveal that the STN plays a critical role in ascertaining the value of the reward and seems to encode that value differently depending on the magnitude of the reward. These data highlight the importance of the STN in the reward circuitry of the brain.


2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Laura Steenbergen ◽  
Roberta Sellaro ◽  
Ann-Kathrin Stock ◽  
Christian Beste ◽  
Lorenza S. Colzato

2015 ◽  
Vol 27 (7) ◽  
pp. 1344-1359 ◽  
Author(s):  
Sara Jahfari ◽  
Lourens Waldorp ◽  
K. Richard Ridderinkhof ◽  
H. Steven Scholte

Action selection often requires the transformation of visual information into motor plans. Preventing premature responses may entail the suppression of visual input and/or of prepared muscle activity. This study examined how the quality of visual information affects frontobasal ganglia (BG) routes associated with response selection and inhibition. Human fMRI data were collected from a stop task with visually degraded or intact face stimuli. During go trials, degraded spatial frequency information reduced the speed of information accumulation and response cautiousness. Effective connectivity analysis of the fMRI data showed action selection to emerge through the classic direct and indirect BG pathways, with inputs deriving form both prefrontal and visual regions. When stimuli were degraded, visual and prefrontal regions processing the stimulus information increased connectivity strengths toward BG, whereas regions evaluating visual scene content or response strategies reduced connectivity toward BG. Response inhibition during stop trials recruited the indirect and hyperdirect BG pathways, with input from visual and prefrontal regions. Importantly, when stimuli were nondegraded and processed fast, the optimal stop model contained additional connections from prefrontal to visual cortex. Individual differences analysis revealed that stronger prefrontal-to-visual connectivity covaried with faster inhibition times. Therefore, prefrontal-to-visual cortex connections appear to suppress the fast flow of visual input for the go task, such that the inhibition process can finish before the selection process. These results indicate response selection and inhibition within the BG to emerge through the interplay of top–down adjustments from prefrontal and bottom–up input from sensory cortex.


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