Resveratrol loaded solid lipid nanoparticles attenuate mitochondrial oxidative stress in vascular dementia by activating Nrf2/HO-1 pathway

2018 ◽  
Vol 112 ◽  
pp. 239-254 ◽  
Author(s):  
Aarti Yadav ◽  
Aditya Sunkaria ◽  
Nitin Singhal ◽  
Rajat Sandhir
Keyword(s):  
Oxidative Stress ◽  
Vascular Dementia ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Mitochondrial Oxidative Stress ◽  
Solid Lipid

Nose to brain delivery of astaxanthin-loaded solid lipid nanoparticles: fabrication, radio labeling, optimization and biological studies

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 10001-10010 ◽  
Author(s):  
Prakash Chandra Bhatt ◽  
Pranay Srivastava ◽  
Preeti Pandey ◽  
Washim Khan ◽  
Bibhu Prasad Panda
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Pc12 Cells ◽  
Solid Lipid Nanoparticles ◽  
Dosage Form ◽  
Lipid Nanoparticles ◽  
Brain Delivery ◽  
Solid Lipid ◽  
Biological Studies ◽  
Conventional Dosage

Astaxanthin nanoformulation was found appropriate in all measures with strong antioxidant activity against H2O2induced oxidative stress in PC12 cells. Biodistribution and brain delivery was also found to be superior to conventional dosage form.

Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles

2009 ◽  
Vol 43 (11) ◽  
pp. 1133-1145 ◽  
Author(s):  
Pasquale Picone ◽  
Maria L. Bondi ◽  
Pasquale Picone ◽  
Maria L. Bondi ◽  
Giovanna Montana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Ferulic Acid ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Enhancement of oral bioavailability of pentoxifylline by solid lipid nanoparticles

2009 ◽  
Vol 00 (00) ◽  
pp. 090820062440031-9 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Mohsen Minayian ◽  
Elaheh Moazen
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Bioavailability ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development and optimization of solid lipid nanoparticles of amikacin by central composite design

2009 ◽  
Vol 00 (00) ◽  
pp. 090721051030036-8
Author(s):  
Jaleh Varshosaz ◽  
Solmaz Ghaffari ◽  
Mohammad Reza Khoshayand ◽  
Fatemeh Atyabi ◽  
Shirzad Azarmi ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Central Composite

Solid lipid nanoparticles for oral delivery of curcumin

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
C Righeschi ◽  
M Bergonzi ◽  
B Isacchi ◽  
A Bilia
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Oral Delivery ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

2009 ◽  
Vol 1 (1) ◽  
Author(s):  
Pravin Patil ◽  
Anil Sharma ◽  
Subhash Dadarwal ◽  
Vijay Sharma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Solid Lipid Nanoparticles ◽  
Rotation Speed ◽  
Lipid Nanoparticles ◽  
Brain Targeting ◽  
Brain Penetration ◽  
Solid Lipid ◽  
Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

Sign in / Sign up

Export Citation Format

Share Document