Age-, gender-, and socioeconomic status-specific incidence of Parkinson's disease and parkinsonism in North East Scotland: The PINE study

2013 ◽  
Vol 19 (5) ◽  
pp. 515-521 ◽  
Author(s):  
Robert Caslake ◽  
Kate Taylor ◽  
Neil Scott ◽  
Joanna Gordon ◽  
Clare Harris ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Socioeconomic Status ◽  
Parkinson's Disease ◽  
North East

Impact of specialist palliative care on coping with Parkinson’s disease: patients and carers

2018 ◽  
Vol 8 (2) ◽  
pp. 180-183 ◽  
Author(s):  
Nathan J Badger ◽  
Dorothy Frizelle ◽  
Debi Adams ◽  
Miriam J Johnson
Keyword(s):  
Parkinson’S Disease ◽  
Palliative Care ◽  
Parkinson's Disease ◽  
Interpretative Phenomenological Analysis ◽  
Specialist Palliative Care ◽  
Advanced Parkinson’S Disease ◽  
Care Access ◽  
North East ◽  
Palliative Care Services ◽  
Positive Outlook

ObjectivesUK guidelines recommend palliative care access for people with Parkinson’s disease; however, this remains sporadic, and it is unknown whether specialist palliative care helps patients and carers cope with this distressing condition. This study aimed to explore whether, and how, access to specialist palliative care services affected patients’ and carers’ coping with Parkinson’s disease.MethodsSemistructured interviews were conducted, audio-recorded and verbatim transcribed. Data were analysed using interpretative phenomenological analysis. Participants were patients with advanced idiopathic Parkinson’s disease (n=3), and carers of people with Parkinson’s disease (n=5, however, one diagnosis was reviewed) receiving care from an integrated specialist palliative care and Parkinson’s disease service in North East England.ResultsAccess to specialist palliative care helped participants cope with some aspects of advanced Parkinson’s disease. Three superordinate themes were developed:‘ managing uncertainty’, ‘impacts on the self’ and ‘specialist palliative care maintaining a positive outlook’.ConclusionsSpecialist palliative care helped patients and carers cope with advanced Parkinson’s disease. Specialist palliative care is a complex intervention that acknowledges the complex and holistic nature of Parkinson’s disease, enabling health in some domains despite continued presence of pathology. These exploratory findings support the utility of this approach for people living with Parkinson’s disease.

scholarly journals The incidence of Parkinson's disease in the North-East of England

2013 ◽  
Vol 43 (2) ◽  
pp. 257-263 ◽  
Author(s):  
G. W. Duncan ◽  
T. K. Khoo ◽  
S. Y. Coleman ◽  
C. Brayne ◽  
A. J. Yarnall ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
North East ◽  
The North

scholarly journals Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in Southern Brazil.

2020 ◽  
Author(s):  
Márcio Schneider Medeiros ◽  
Sumanth P. Reddy ◽  
Mariana P. Socal ◽  
Artur Francisco Schumacher-Schuh ◽  
Carlos Roberto de Mello Rieder
Keyword(s):  
Parkinson’S Disease ◽  
Socioeconomic Status ◽  
Parkinson's Disease ◽  
Pesticide Exposure ◽  
Cox Proportional Hazards Model ◽  
Caffeine Intake ◽  
Southern Brazil ◽  
Risk Of Death ◽  
History Of ◽  
The Impact

Abstract Background: Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. However, the evidence regarding the impact of pesticide exposure on mortality among patients with PD is equivocal. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil. Methods: A total of 150 patients with idiopathic PD were enrolled from 2008-2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures. Results: Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.018). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history (HR = 2.23, 95% CI [1.09, 4.59], p = 0.03)) and another which included several measures of socioeconomic status (HR = 3.91, 95% CI [1.32, 11.58], p = 0.01).Conclusion: In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.

The prevalence of Parkinson’s disease in a rural area of North-East England

2010 ◽  
Vol 16 (9) ◽  
pp. 572-575 ◽  
Author(s):  
Richard W. Walker ◽  
Annette Hand ◽  
Catherine Jones ◽  
Brian H. Wood ◽  
William K. Gray
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rural Area ◽  
North East

scholarly journals Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in Southern Brazil.

2020 ◽  
Author(s):  
Márcio Schneider Medeiros ◽  
Sumanth P. Reddy ◽  
Mariana P. Socal ◽  
Artur Francisco Schumacher-Schuh ◽  
Carlos Roberto de Mello Rieder
Keyword(s):  
Parkinson’S Disease ◽  
Socioeconomic Status ◽  
Parkinson's Disease ◽  
Proportional Hazards Model ◽  
Pesticide Exposure ◽  
Cox Proportional Hazards Model ◽  
Caffeine Intake ◽  
Southern Brazil ◽  
Risk Of Death ◽  
History Of

Abstract Background Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil, when accounting for socioeconomic status, nicotine exposure, and caffeine exposure. Methods 150 patients with idiopathic PD were enrolled from 2008-2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures. Results Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.22). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history and another which included several measures of socioeconomic status. Conclusion In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.

scholarly journals First delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors, and outcomes

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Samantha Green ◽  
Sarah L. Perrott ◽  
Andrew McCleary ◽  
Isobel Sleeman ◽  
Jodi Maple-Grødem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Confidence Interval ◽  
Early Identification ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Atypical Parkinsonism ◽  
Vascular Parkinsonism ◽  
Community Based ◽  
North East

AbstractTo define the incidence, predictors and prognosis of the first hospital delirium episode in Parkinson’s disease (PD) and atypical parkinsonism (AP), we identified the first hospital episode of delirium after diagnosis in the Parkinsonism Incidence in North-East Scotland (PINE) study, a prospective community-based incidence cohort of parkinsonism, using chart-based criteria to define delirium. Of 296 patients (189=PD, 107=AP [dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, vascular parkinsonism]), 152 developed delirium (PD = 98, AP = 54). Incidence of first hospital delirium episode per 100 person years was 8.1 (95% confidence interval [CI] 6.6–9.9) in PD and 18.5 (95% CI 13.9–24.7) in AP. Independent predictors of delirium were atypical parkinsonism (Hazard ratio [HR] vs PD = 2.83 [95% CI 1.60–5.03], age in PD but not in AP (HR for 10-year increase 2.29 [95% CI 1.74–3.02]), baseline MMSE (HR = 0.94 [95% CI 0.89–0.99]), APOE ε4 in PD (HR 2.16 [95% CI 1.15–4.08]), and MAPT H1/H1 in PD (HR 2.08 [95% CI 1.08–4.00]). Hazards of dementia and death after delirium vs before delirium were increased (dementia: HR = 6.93 [95% CI 4.18–11.48] in parkinsonism; death: HR = 3.76 [95% CI 2.65–5.35] in PD, 1.59 [95% CI 1.04–2.42] in AP). Delirium is a common non-motor feature of PD and AP and is associated with increased hazards of dementia and mortality. Whether interventions for early identification and treatment improve outcomes requires investigation.

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