Cardiac MRI shows an association of lower cardiorespiratory fitness with decreased myocardial mass and higher cardiac stiffness in the general population – The sedentary's heart

2021 ◽  
Author(s):  
Marcello Ricardo Paulista Markus ◽  
Till Ittermann ◽  
Christine Julia Drzyzga ◽  
Martin Bahls ◽  
Sabine Schipf ◽  
...  
Keyword(s):  
General Population ◽  
Cardiorespiratory Fitness ◽  
Cardiac Mri ◽  
Myocardial Mass

Galectin-3 is inversely associated with cardiorespiratory fitness in the general population

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
M Haid ◽  
M Bahls ◽  
M Doerr ◽  
S Felix ◽  
S Zylla ◽  
...  
Keyword(s):  
General Population ◽  
Oxygen Uptake ◽  
Cardiorespiratory Fitness ◽  
Extreme Values ◽  
Cardiopulmonary Exercise Testing ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Linear Regression Models ◽  
Ventricular Ejection Fraction ◽  
Galectin 3

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Low cardiorespiratory fitness (CRF) is associated with high mortality and morbidity. Galectin-3 (Gal-3) is a prognostic biomarker for fibrosis, different cancers, renal impairment and, in particular, for heart failure. Further, higher Gal-3 levels are associated with increased cardiovascular mortality. Whether Gal-3 is related with the protective effects of a high CRF is unclear. Purpose The present study examined the relation between Gal-3 and CRF as determined by body weight adjusted peak oxygen uptake (VO2peak/kg), oxygen uptake at the anaerobic threshold (VO2@AT) and maximal workload (Wmax). Methods We used data of the population-based Study of Health in Pomerania (SHIP-TREND) from Northeast Germany. A total of n = 1,483 participants with a median age of 49 (IQR: 39 – 59 years, male 48%) were included in the analysis. CRF parameters were measured using standardized cardiopulmonary exercise testing on a bicycle ergometer. Plasma galectin-3 concentrations were determined using a quantitative sandwich enzyme immunoassay. Individuals with left ventricular ejection fraction < 40%, previous myocardial infarction, atrial fibrillation, chronic lung disease, severe renal disease (eGFR < 30 ml/min/mm2), a history of cancer, and extreme values for Gal-3 were excluded. Linear regression models adjusted for age, sex and lean mass were used to analyze the association between Gal-3 and CRF. Results A one ml/min/kg greater VO2peak was related to a 0.32 ng/ml (95% confidence interval [CI] -0.45 to -0.18, p <.001) lower Gal-3. Further, a one Watt larger power output was also associated with a 1.32 ng/ml (95% CI -2.10 to – 0.54, p <.001) lesser Gal-3. VO2@AT was not related to Gal-3 (β: -3.31 95% CI -8.68 to 2.05, p = .23). Conclusions In the general population Gal-3 is inversely associated with CRF. Further studies should investigate whether lower Gal-3, beyond its importance as a biomarker for heart disease, may even play a role in the protective effect of the CRF.

scholarly journals Sex-Specific Associations of Brain-Derived Neurotrophic Factor and Cardiorespiratory Fitness in the General Population

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 630 ◽  
Author(s):  
Marie-Lena Schmalhofer ◽  
Marcello R.P. Markus ◽  
Jan C. Gras ◽  
Juliane Kopp ◽  
Deborah Janowitz ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
General Population ◽  
Cardiorespiratory Fitness ◽  
Neurotrophic Factor ◽  
Maximal Oxygen Consumption ◽  
Brain Derived Neurotrophic Factor ◽  
Linear Regression Models ◽  
General Population Study ◽  
Specific Association ◽  
Serum Bdnf

The brain-derived neurotrophic factor (BDNF) was initially considered to be neuron-specific. Meanwhile, this neurotrophin is peripherally also secreted by skeletal muscle cells and increases due to exercise. Whether BDNF is related to cardiorespiratory fitness (CRF) is currently unclear. We analyzed the association of serum BDNF levels with CRF in the general population (Study of Health in Pomerania (SHIP-TREND) from Northeast Germany; n = 1607, 51% female; median age 48 years). Sex-stratified linear regression models adjusted for age, height, smoking, body fat, lean mass, physical activity, and depression analyzed the association between BDNF and maximal oxygen consumption (VO2peak), maximal oxygen consumption normalized for body weight (VO2peak/kg), and oxygen consumption at the anaerobic threshold (VO2@AT). In women, 1 mL/min higher VO2peak, VO2peak/kg, and VO2@AT were associated with a 2.43 pg/mL (95% confidence interval [CI]: 1.16 to 3.69 pg/mL; p = 0.0002), 150.66 pg/mL (95% CI: 63.42 to 237.90 pg/mL; p = 0.0007), and 2.68 pg/mL (95% CI: 0.5 to 4.8 pg/mL; p = 0.01) higher BDNF serum concentration, respectively. No significant associations were found in men. Further research is needed to understand the sex-specific association between CRF and BDNF.

Vitamin D and Cardiorespiratory Fitness in the General Population: A Systematic Review

2017 ◽  
Vol 87 (5-6) ◽  
pp. 330-341
Author(s):  
Omid Eslami1 ◽  
Farzad Shidfar1 ◽  
Maryam Akbari-Fakhrabadi2
Keyword(s):  
Vitamin D ◽  
General Population ◽  
Cardiorespiratory Fitness ◽  
Strong Association ◽  
High Quality Research ◽  
Cross Sectional ◽  
Manual Search ◽  
Mesh Terms ◽  
Study Results ◽  
Cross Sectional Studies

Abstract. Background: Up to now, the association between vitamin D and cardiorespiratory fitness (CRF) is still inconsistent and there is a lack of a comprehensive review on this topic. Aim: To systematically review the literature including both observational studies and randomized controlled trials (RCTs) on the association between vitamin D and CRF in the general population. Methods: The literature was investigated by exploring databases of PubMed, EMBASE, Scopus and ISI Web of Science as well as a manual search up to April 2017 by using related MeSH terms and key words. All the English-language articles that were conducted in the general population without any restriction on age range of participants and date of publication were included in the study. Results: Among the 731 records which were found initially, a total of 20 articles including 18 cross-sectional studies and 2 RCTs fulfilled the inclusion criteria. Among the cross-sectional studies, findings on the association between serum 25(OH) D and CRF were incongruent. Additionally, studies which had reported significant results varied remarkably in terms of sample size, study population and the effect size of the association. In addition, RCTs found no significant improvement in CRF following vitamin D supplementation. Conclusion: Overall, evidence from cross-sectional studies does not support a strong association between vitamin D and CRF, although a number of studies demonstrated modest positive associations. Furthermore, limited RCTs did not confirm such an association. Further high quality research is needed to obtain a definite conclusion on this topic. “

scholarly journals Review: Mortality trends in the general population: the importance of cardiorespiratory fitness

2010 ◽  
Vol 24 (4_suppl) ◽  
pp. 27-35 ◽  
Author(s):  
Duck-chul Lee ◽  
Enrique G Artero ◽  
Xuemei Sui ◽  
Steven N Blair
Keyword(s):  
General Population ◽  
Cardiorespiratory Fitness ◽  
Mortality Trends

scholarly journals Association Between Cardiorespiratory Fitness and Accelerometer-Derived Physical Activity and Sedentary Time in the General Population

2014 ◽  
Vol 89 (8) ◽  
pp. 1063-1071 ◽  
Author(s):  
Jacquelyn P. Kulinski ◽  
Amit Khera ◽  
Colby R. Ayers ◽  
Sandeep R. Das ◽  
James A. de Lemos ◽  
...  
Keyword(s):  
Physical Activity ◽  
General Population ◽  
Cardiorespiratory Fitness ◽  
Sedentary Time

Cardiorespiratory Fitness Among Individuals With Psoriasis in the General Population

2016 ◽  
Vol 13 (7) ◽  
pp. 771-775 ◽  
Author(s):  
Patrick B. Wilson
Keyword(s):  
Physical Activity ◽  
General Population ◽  
Surface Area ◽  
Body Surface Area ◽  
Cardiorespiratory Fitness ◽  
Body Surface ◽  
Secondary Data ◽  
Limited Data ◽  
Cardiometabolic Disorders ◽  
Psoriasis Severity

Background:Psoriasis confers risk for cardiometabolic disorders. Cardiorespiratory fitness is inversely associated with risk of cardiometabolic disorders in other populations, but limited data have been published assessing cardiorespiratory fitness among individuals with psoriasis. This investigation aimed to: 1) assess cardiorespiratory fitness among individuals with psoriasis in the general population; and 2) compare levels to individuals without psoriasis.Methods:A secondary data analysis from the 2003–2004 National Health and Nutritional Examination Survey was performed. Cardiorespiratory fitness was assessed with a treadmill test, while measures of psoriasis severity included rating of psoriasis as a life problem and body surface area involvement.Results:Twenty-six of 1093 participants reported a psoriasis diagnosis (population weighted prevalence 2.9%). Individuals with psoriasis had lower cardiorespiratory fitness compared with individuals without psoriasis (36.2 vs. 39.1 mL∙kg-1∙min-1, P = .009). No differences in self-reported or accelerometer physical activity were found by psoriasis diagnosis. Cardiorespiratory fitness was not significantly lower in those reporting high life impairment or body surface area involvement.Conclusions:Cardiorespiratory fitness may be lower in individuals with psoriasis and these differences may not be explained by self-reported disease severity measures or physical activity. Future studies should examine whether validated measures of psoriasis severity predict lower cardiorespiratory fitness.

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