scholarly journals Serosal surface small vessel vasculitis in Henoch-Schonlein purpura

2020 ◽  
Vol 61 (4) ◽  
pp. 447-448
Author(s):  
Way Seah Lee ◽  
Chong Tuan Koh
Keyword(s):  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Serosal Surface ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

scholarly journals Henoch-Schonlein Purpura in Children: The Role of Corticosteroids

2019 ◽  
Vol 7 (11) ◽  
pp. 1812-1814
Author(s):  
Bella Kurnia
Keyword(s):  
Abdominal Pain ◽  
Renal Disease ◽  
Systemic Vasculitis ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Progression Of Renal Disease ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

BACKGROUND: Henoch- schonlein purpura (HSP) is an IgA- mediated systemic small vessel vasculitis. It is the most common form of systemic vasculitis in children.CASE REPORT: A 9 years old girl admitted to the hospital with chief complain of purplish red rash on both legs since approximately 1 week with painful knees and ankles that make the patient unable to walk. The patient was diagnosed with HSP and was treated with corticosteroid and analgesics. The patients only stayed for 2 nights at the hospital and discharged from the hospital with the ability to walk and experience no pain. CONCLUSION: The role of corticosteroids in the treatment of HSP is still controversial. But from various research, we can conclude that the role of corticosteroid in HSP is as a symptom reliever (reduce abdominal pain and arthritis), but does not slow the progression of renal disease.

scholarly journals Henoch-Schonlein purpura associated with HLA-B27 positive axial spondyloarthritis in a young man

2019 ◽  
Vol 12 (5) ◽  
pp. e228881 ◽  
Author(s):  
Kevin John John ◽  
Mohammad Sadiq ◽  
Meera Thomas ◽  
Vijay Prakash Turaka
Keyword(s):  
Axial Spondyloarthritis ◽  
Case Reports ◽  
Lower Limbs ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Hla B27 ◽  
Henoch Schonlein Purpura ◽  
Seronegative Spondyloarthropathies ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Axial spondyloarthropathies are characterised by bilateral sacroiliitis, asymmetric oligoarthritis, association with the human leucocyte antigen (HLA)-B27, enthesitis and dactylitis. Although IgA nephropathy has a well-documented association with seronegative spondyloarthropathies, the association with Henoch-Schonlein purpura (HSP) has been documented only in few case reports. The present case is that of a 26-year-old man who presented with fever, lower limb arthritis, abdominal pain, palpable purpura over the buttocks and lower limbs, and clinical features of sacroiliitis. His blood tests showed elevated inflammatory markers and rheumatoid factor was negative. CT scan of the sacroiliac joints confirmed sacroiliitis. Skin biopsy revealed neutrophilic small vessel vasculitis. HLA-B27 was positive in blood. A diagnosis of HSP with HLA-B27 positive axial spondyloarthritis was made. HSP can be associated with HLA-B27 positive axial spondyloarthritis and has to be considered while evaluating for causes of cutaneous small vessel vasculitis in such patients.

Altered mean platelet volume in children with Henoch-Schonlein purpura and its association with disease activity

2017 ◽  
Vol 55 (3) ◽  
pp. 368-372
Author(s):  
Xiang Shi ◽  
Wen-Chao Li ◽  
Li-Jun Mo ◽  
Xiao-Hong Li ◽  
Yu-Zhen Luo ◽  
...  
Keyword(s):  
Acute Phase ◽  
Mean Platelet Volume ◽  
Area Under The Curve ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Platelet Volume ◽  
Convalescent Phase ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Therefore, our study aimed to evaluate the role of mean platelet volume concentrations in patients with Henoch-Schonlein purpura. Methods This study included 97 children with Henoch-Schonlein purpura and 120 healthy individuals as controls. Results Mean platelet volume concentrations were found to be significantly lower in Henoch-Schonlein purpura patients compared with healthy controls (8.1 ± 0.86 vs. 9.4 ± 0.81, P < 0.001). Similarly, significant negative correlations were observed between mean platelet volume and neutrophil count, platelet count and erythrocyte sedimentation rate in patients with Henoch-Schonlein purpura (r=−0.327, P = 0.001; r=−0.419, P < 0.001; r=−0.255, P = 0.012). Interestingly, mean platelet volume was significantly lower in the acute phase compared with the convalescent phase of Henoch-Schonlein purpura patients (7.8 ± 0.86 vs. 8.3 ± 0.77, P = 0.002). A cut-off value for mean platelet volume was 7.85 with area under the curve of 0.726 to identify acute phase vs. convalescent phase in patients with Henoch-Schonlein purpura. Mean platelet volume was independently associated with Henoch-Schonlein purpura in logistic regression analysis (odds ratio = 0.114, 95% confidence interval = 0.053–0.243, P < 0.001). Conclusions Our results suggest that mean platelet volume is inversely associated with disease in patients with Henoch-Schonlein purpura, and mean platelet volume may be a useful marker to identify active disease in Henoch-Schonlein purpura patients.

scholarly journals An unusual case of transient cortical blindness with sagittal sinus thrombosis in a case of Henoch-Schonlein purpura

2012 ◽  
Vol 4 (2) ◽  
pp. 333-335 ◽  
Author(s):  
S K Samanta ◽  
N Mahapatra ◽  
B Aich ◽  
N Sarkar ◽  
A Chatterjee
Keyword(s):  
Unusual Case ◽  
Sinus Thrombosis ◽  
Cortical Blindness ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
High Grade Fever ◽  
Diffuse Abdominal Pain ◽  
Transient Cortical Blindness ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Introduction: Henoch-Schonlein purpura (HSP) is one of the most common causes of small vessel vasculitis in children, but sometimes may have an atypical presentation. Objective: To report an unusual case of transient cortical blindness in a patient with Henoch-Schonlein purpura. Case: A 3-year-old female child was brought with the complaint of diffuse abdominal pain and hematochezia, which was preceded by high grade fever and cough. Three days later she developed hematuria, hematemesis, melena and hemoptysis along with palpable purpura. Four days later she became irritable and developed a few episodes of generelized tonic clonic seizure, followed by cortical blindness. The CT scan of the brain showed bilateral nonenhancing occipital hypodensity. The magnetic resonance venography showed thrombosis in transverse and sigmoid sinus. She was treated with corticosteroids and her mental status and vision improved. Conclusion: The HSP can cause transient cortical blindness, and recovery is good if therapy is initiated at the appropriate time.DOI: http://dx.doi.org/10.3126/nepjoph.v4i2.6556 Nepal J Ophthalmol 2012; 4 (2): 333-335

scholarly journals Koebner phenomenon in leukocytoclastic vasculitis: A case report and an updated review of the literature

2019 ◽  
Vol 7 ◽  
pp. 2050313X1985035
Author(s):  
Farah Kassam ◽  
Sabrina Nurmohamed ◽  
Richard M Haber
Keyword(s):  
Case Report ◽  
Leukocytoclastic Vasculitis ◽  
Immunoglobulin A ◽  
Small Vessel Vasculitis ◽  
Review Of The Literature ◽  
Henoch Schonlein Purpura ◽  
Koebner Phenomenon ◽  
Vessel Injury ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Leukocytoclastic vasculitis is the most common form of cutaneous vasculitis. It is a neutrophilic small vessel vasculitis resulting from the deposition of circulating immune complexes. Henoch-Schonlein purpura is a systemic type of leukocytoclastic vasculitis, characterized by immunoglobulin A-mediated blood vessel injury. We present a case of Henoch-Schonlein purpura in an adult female manifesting with a vasculitic rash with Koebner phenomenon.

scholarly journals Severe Disfiguring Scalp and Facial Oedema due to Henoch–Schönlein Purpura in a Child

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Visvalingam Arunath ◽  
Arjuna Salinda Athapathu ◽  
Thabitha Jebaseeli Hoole ◽  
Heshan Aruppala ◽  
Asanka Rathnasri ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Urine Analysis ◽  
The Body ◽  
Small Vessel Vasculitis ◽  
Facial Oedema ◽  
Normal Brain ◽  
Henoch Schonlein Purpura ◽  
Facial Swelling ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch–Schönlein purpura is a small vessel vasculitis that usually presents with palpable purpura, arthritis, abdominal pain, and nephritis. Subcutaneous oedema of dependent areas is common; however, oedema in the scalp is extremely rare especially in children older than two years. Here, we report a child with massive disfiguring scalp and facial oedema due to Henoch–Schönlein purpura. An eight-year-old boy presented with characteristic palpable purpuric rash and extensive disfiguring scalp and facial swelling for five days. He complained of blurred vision, vomiting, and severe headache on the day of admission. Examination revealed an ill child with extensive oedema of the face and scalp that was tender on palpation. His blood pressure was above the 99th percentile, and he had exaggerated deep tendon reflexes and extensor plantar responses. All biochemical investigations including renal function tests were normal. Noncontrast CT head showed normal brain, with marked soft tissue swelling of the scalp. Ultrasonography showed soft tissue oedema within and surrounding facial muscles without evidence of neck vessel compression. Urine analysis revealed microscopic haematuria on day 14 of the illness, and immunohistochemical staining of renal biopsy confirmed Henoch–Schönlein purpura nephritis. In conclusion, this case report presents a child with severe, disfiguring scalp and facial oedema due to Henoch–Schönlein purpura. It highlights that severe subcutaneous oedema of Henoch–Schönlein purpura can involve any part of the body not limiting to dependent areas.

scholarly journals The Characteristics of Video Capsule Endoscopy in Pediatric Henoch–Schönlein Purpura with Gastrointestinal Symptoms

2020 ◽  
Author(s):  
Youhong Fang ◽  
Kerong Peng ◽  
Hong Zhao ◽  
Jie Chen
Keyword(s):  
Gastrointestinal Tract ◽  
Capsule Endoscopy ◽  
Gastrointestinal Symptoms ◽  
Video Capsule Endoscopy ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Laboratory Findings ◽  
Pass Through ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Abstract Background Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis that commonly affects gastrointestinal tract. The video capsule endoscopy (VCE) characteristics of pediatric HSP patients were rarely investigated. Methods Patients diagnosed with HSP by VCE examination at our hospital from February 2010 to January 2019 are analyzed. The clinical features, laboratory findings, and the characteristics of VCE findings are studied. Results There are 30 patients enrolled in this investigation from February 2010 to January 2020. The mean age of these patients is 96.9±35.8 months, and the most frequent finding of VCE is mucosal erosion, which account for 69 % of the patients, and followed by mucosal erythema or petechia accounted for 79.3 % of the patients. Regarding to the disease location detected by endoscopy, jejunum is the most common involved part of the gastrointestinal tract in pediatric HSP patients. All the patients had jejunum involved except in one patient the VCE did not pass through the pylorus. One third of the patients involved the descent part of duodenum. No side effects are observed in this study. Conclusions VCE is safe and effective in the diagnosis of gastrointestinal involved HSP patients with or without typical skin purpura. Jejunum is the most common involve location in gastrointestinal.

Henoch-Schonlein Purpura

2020 ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Nephrotic Syndrome ◽  
Joint Pain ◽  
Laboratory Tests ◽  
Immunoglobulin A ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Key Points ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Key Points Henoch-Schönlein purpura (HSP) is the most common form of vasculitis in children.It is a small-vessel vasculitis mediated by immunoglobulin A–containing immune complexes and characterized by nonthrombocytopenic purpura, abdominal pain, arthralgia, and renal disease.Diagnosis of HSP is clinical, and no laboratory tests are specific for HSP.Treatment is supportive. Patients with severe abdominal and joint pain may be treated with steroids.Steroids do not prevent renal disease in patients with HSP.Patients with nephritic or nephrotic syndrome have a much higher risk of developing chronic kidney disease and should be referred to a nephrologist.

scholarly journals Henoch-Schonlein Purpura—A Case Report and Review of the Literature

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Amit B. Sohagia ◽  
Srinivas Guptha Gunturu ◽  
Tommy R. Tong ◽  
Hilary I. Hertan
Keyword(s):  
Early Recognition ◽  
Leukocytoclastic Vasculitis ◽  
Systemic Disease ◽  
Renal Involvement ◽  
Symptomatic Treatment ◽  
Adolescent Male ◽  
Small Vessel Vasculitis ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

We describe a case of an adolescent male with Henoch-Schonlein purpura (HSP), presenting with cutaneous and gastrointestinal manifestations. Endoscopy revealed diffuse ulcerations in the stomach, duodenum, and right colon. Biopsies revealed a leukocytoclastic vasculitis in the skin and gastrointestinal tract. Steroid therapy led to complete resolution of the symptoms. HSP is the most common childhood vasculitis, and is characterized by the classic tetrad of nonthrombocytopenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. It is a systemic disease where antigen-antibody (IgA) complexes activate the alternate complement pathway, resulting in inflammation and small vessel vasculitis. Mild disease resolves spontaneously, and symptomatic treatment alone is sufficient. Systemic steroids are recommended for moderate to severe HSP. The prognosis depends upon the extent of renal involvement, which requires close followup. Early recognition of multiorgan involvement, especially outside of the typical age group, as in our adolescent patient, and appropriate intervention can mitigate the disease and limit organ damage.

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