Krill oil-based self-emulsifying drug delivery system to improve oral absorption and renoprotective function of ginger extract

2021 ◽  
pp. 100285
Author(s):  
Mizuki Ogino ◽  
Asuka Nakazawa ◽  
Kenichi Shiokawa ◽  
Hiroshi Kikuchi ◽  
Hideyuki Sato ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Krill Oil ◽  
Ginger Extract

Supersaturable Self-Emulsifying Drug Delivery System of Krill Oil with Improved Oral Absorption and Hypotriglyceridemic Function

2018 ◽  
Vol 66 (21) ◽  
pp. 5352-5358 ◽  
Author(s):  
Yoshiki Seto ◽  
Chikara Morizane ◽  
Kodai Ueno ◽  
Hideyuki Sato ◽  
Satomi Onoue
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Krill Oil

scholarly journals Enhanced Bioavailability of AC1497, a Novel Anticancer Drug Candidate, via a Self-Nanoemulsifying Drug Delivery System

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1142
Author(s):  
Kshitis Chandra Baral ◽  
Jae-Geun Song ◽  
Sang Hoon Lee ◽  
Rajiv Bajracharya ◽  
Godesi Sreenivasulu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Plasma Concentration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Metabolism ◽  
Oral Absorption ◽  
Drug Candidate ◽  
Maximum Plasma ◽  
Time Curve ◽  
Dual Inhibitor

AC1497 is an effective dual inhibitor of malate dehydrogenase 1 and 2 targeting cancer metabolism. However, its poor aqueous solubility results in low bioavailability, limiting its clinical development. This study was conducted to develop an effective self-nanoemulsifying drug delivery system (SNEDDS) of AC1497 to improve its oral absorption. Based on the solubility of AC1497 in various oils, surfactants, and cosurfactants, Capryol 90, Kolliphor RH40, and Transcutol HP were selected as the components of SNEDDS. After testing various weight ratios of Capryol 90 (20–30%), Kolliphor RH40 (35–70%), and Transcutol HP (10–35%), SNEDDS-F4 containing 20% Capryol 90, 45% Kolliphor RH40, and 35% Transcutol HP was identified as an optimal SNEDDS with a narrow size distribution (17.8 ± 0.36 nm) and high encapsulation efficiency (93.6 ± 2.28%). Drug release from SNEDDS-F4 was rapid, with approximately 80% of AC1497 release in 10 min while the dissolution of the drug powder was minimal (<2%). Furthermore, SNEDDS-F4 significantly improved the oral absorption of AC1497 in rats. The maximum plasma concentration and area under the plasma concentration–time curve of AC1497 were, respectively 6.82- and 3.14-fold higher for SNEDDS-F4 than for the drug powder. In conclusion, SNEDDS-F4 with Capryol 90, Kolliphor RH40, and Transcutol HP (20:45:35, w/w) effectively improves the solubility and oral absorption of AC1497.

scholarly journals FORMULATION AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF SPIRONOLACTONE

1970 ◽  
Vol 7 (1) ◽  
pp. 38-40
Author(s):  
Ankur Gupta ◽  
Arpna Indurkhya ◽  
S.C Chaturvedi ◽  
Ajit Varma
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Tween 80 ◽  
Water Soluble ◽  
Absolute Bioavailability ◽  
Polyethylene Glycol 400

Spironolactone is aldosterone antagonist drug belonging to the category of potassium sparing diuretics administered orally that has absolute bioavailability of only 68% due to the poor aqueous solubility. The main aim of the present work was to develop a self emulsifying drug delivery system (SEDDS) to enhance the oral absorption of spironolactone. The solubility of spironolactone in various oils, surfactants, and co surfactants was determined. Pseudo ternary phase diagrams were constructed using castor oil, Tween 80, and polyethylene glycol 400, and distilled water to identify the efficient self-micro emulsion region. Prepared self emulsifying drug delivery system was further evaluated for its emulsification time, drug content, optical clarity, droplet size, zeta potential, in vitro drug release. The results showed that 96.16% drug was released from the SEDDS formulation in 3 hrs. This demonstrated an enhancement in the drug release and thereby, absorption of the drug through the membrane, this was significantly higher than that of the plain drug suspension. Thus, the above findings support that the utility of SEDDS to enhance solubility and dissolution of poorly water soluble compounds which may result in improved Therapeutic performance.

scholarly journals Characterization and antihypertensive activity of ginger extract-eel bone oil SNEDDS (selfnanoemulsifying drug delivery system)

2021 ◽  
Vol 48 (1) ◽  
pp. 90-98
Author(s):  
Fea Prihapsara ◽  
Imas Ifrian Wijayanti ◽  
Agung Budiharjo ◽  
Artini Pangastut ◽  
Anif Nur Artanti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Antihypertensive Activity ◽  
Ginger Extract

scholarly journals Self Emulsifying Drug Delivery System: A Recent Approach

2019 ◽  
Vol 31 (4) ◽  
pp. 751-759 ◽  
Author(s):  
Sabitri Bindhani ◽  
S. Mohapatra ◽  
R.K. Kar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Oral Absorption ◽  
Scale Up ◽  
Aqueous Solubility ◽  
Oral Drug ◽  
Recent Approach ◽  
Poorly Soluble

In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

Formulating a single thioether-bridged oleate prodrug into a self-nanoemulsifying drug delivery system to facilitate oral absorption of docetaxel

2019 ◽  
Vol 7 (3) ◽  
pp. 1117-1131 ◽  
Author(s):  
Weiping Cui ◽  
Shenwu Zhang ◽  
Hanqing Zhao ◽  
Cong Luo ◽  
Bingjun Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Lymphatic Transport

Single thioether-bridged oleate prodrug (DTX-S-OA) efficiently incorporated into SNEDDS can avoid P-gp efflux, facilitate lymphatic transport and thus improve bioavailability.

Self-Emulsifying Drug Delivery System of Celecoxib for Avoiding Delayed Oral Absorption in Rats with Impaired Gastric Motility

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Keisuke Yakushiji ◽  
Hideyuki Sato ◽  
Mizuki Ogino ◽  
Hiroki Suzuki ◽  
Yoshiki Seto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Gastric Motility ◽  
Oral Absorption

The high potency of polymeric nanoparticles in the drug delivery system for hypertension treatment; A systematic review

2021 ◽  
Vol 17 ◽  
Author(s):  
Fatemeh Mohammadipour ◽  
Aliasghar Kiani ◽  
Arash Amin
Keyword(s):  
Systematic Review ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Absorption ◽  
Polymeric Nanoparticles ◽  
Hypertension Treatment ◽  
High Potency

Background: Polymeric nanomaterials with size ranging from 10 to 1000 nm are one of the most widely used types of nanoparticles with ideal properties in the drug delivery systems. Here, we decided to systematically review the antihypertensive effects of polymeric nanomaterials in vitro, in vivo, and clinical trials. Methods: The present review was conducted based on the 06- PRISMA guideline; whereas five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar without time limitation were used for searching the publications related to antihypertensive effects of natural and synthetic polymeric nanoparticles. Results: The results demonstrated that among 1701 papers, 25 papers including 11 in vitro (44%), 6 in vivo (24%), 7 in vitro / in vivo (28%), and 1 in vitro / ex vivo (4%) up to 2020, met the inclusion criteria for discussion in this systematic review. The most used nanoparticles poly-(lactic-co-glycolic) acid nanoparticle (PLGANPs) (7, 29.2%), chitosan based nanoparticles (6, 25%), followed by polylactide acid nanoparticles (5, 20.8%). Conclusion: We concluded that the high potency of polymeric nanoparticles in the drug delivery system for hypertension treatment. Although the accurate mechanisms are not fully understood; however, some mechanisms such as sustained release forms with increased bioavailability, increasing oral bioavailability and improve the oral and non-oral absorption, counteracting excessive superoxide and decreasing blood pressure, etc can be related these nanoparticles.

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