Role of apoptosis in pulmonary hypertension: From experimental models to clinical trials

2010 ◽  
Vol 126 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Paul Jurasz ◽  
David Courtman ◽  
Saeid Babaie ◽  
Duncan J. Stewart
Keyword(s):  
Clinical Trials ◽  
Pulmonary Hypertension ◽  
Experimental Models

scholarly journals Pulmonary Hypertension Roundtable: The Role of Exercise in Clinical Practice and Clinical Trials

2019 ◽  
Vol 18 (2) ◽  
pp. 63-67
Keyword(s):  
Clinical Trials ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Clinical Practice ◽  
Los Angeles ◽  
Guest Editor ◽  
Harvard Medical School ◽  
Medical Center ◽  
Professor Emeritus

On May 20, 2019, Guest Editor Ronald Oudiz, MD, Director of the Pulmonary Hypertension Program at Harbor-UCLA Medical Center in Los Angeles, California, led a discussion with Aaron Waxman, MD, PhD, Director of the Center for Pulmonary Heart Disease at Brigham and Women's Hospital and Harvard Medical School in Boston, Massachusetts, and Robert Naeije, MD, Professor Emeritus at the Free University of Brussels, Belgium.

scholarly journals Inflammation and autoimmunity in pulmonary hypertension: is there a role for endothelial adhesion molecules? (2017 Grover Conference Series)

2018 ◽  
Vol 8 (2) ◽  
pp. 204589321875759 ◽  
Author(s):  
Wolfgang M. Kuebler ◽  
Sébastien Bonnet ◽  
Arata Tabuchi
Keyword(s):  
Pulmonary Hypertension ◽  
Potential Role ◽  
Disease Process ◽  
Experimental Models ◽  
Therapeutic Interventions ◽  
Pulmonary Resistance ◽  
Resistance Vessels ◽  
Endothelial Adhesion Molecules ◽  
Inflammatory Component

While pulmonary hypertension (PH) has traditionally not been considered as a disease that is directly linked to or, potentially, even caused by inflammation, a rapidly growing body of evidence has demonstrated the accumulation of a variety of inflammatory and immune cells in PH lungs, in and around the wall of remodeled pulmonary resistance vessels and in the vicinity of plexiform lesions, respectively. Concomitantly, abundant production and release of various inflammatory mediators has been documented in both PH patients and experimental models of PH. While these findings unequivocally demonstrate an inflammatory component in PH, they have fueled an intense and presently ongoing debate as to the nature of this inflammatory aspect: is it a mere bystander of or response to the actual disease process, or is it a pathomechanistic contributor or potentially even a trigger of endothelial injury, smooth muscle hypertrophy and hyperplasia, and the resulting lung vascular remodeling? In this review, we will discuss the present evidence for an inflammatory component in PH disease with a specific focus on the potential role of the endothelium in this scenario and highlight future avenues of experimental investigation which may lead to novel therapeutic interventions.

What is the Role of Erythropoietin in Acute Myocardial Infarct? Bridging the Gap Between Experimental Models and Clinical Trials

2013 ◽  
Vol 27 (4) ◽  
pp. 315-331 ◽  
Author(s):  
François Roubille ◽  
Fabrice Prunier ◽  
Stéphanie Barrère-Lemaire ◽  
Florence Leclercq ◽  
Christophe Piot ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Myocardial Infarct ◽  
Experimental Models ◽  
Acute Myocardial Infarct

scholarly journals Role of mesenchymal stromal cells and their secretory products in kidney regeneration

2021 ◽  
Vol 11 (3) ◽  
pp. 57-69
Author(s):  
O. V. Payushina ◽  
D. A. Tsomartova ◽  
E. V. Chereshneva ◽  
M. Yu. Ivanova ◽  
T. A. Lomanovskaya ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Kidney Diseases ◽  
Medical Problem ◽  
Experimental Models ◽  
Secretory Products ◽  
Injured Kidney

Kidney diseases are an important medical problem. Kidney injuries are accompanied by oxidative stress, cell death, capillary destruction, inflammation and fibrosis. Mesenchymal stromal cells (MSCs) have a complex effect on the regeneration by producing various regulatory molecules, including those inside extracellular vesicles, and therefore are considered as a promising therapeutic resource for cell therapy of kidney diseases. Their renoprotective effect has been shown in different experimental models, but the results of the clinical trials are ambiguous. Clinical use of MSCs is complicated by their low survival rate in the injured kidney, potential immunogenicity, tumorogenicity and fibrogenicity. Cell-free therapy with the secretory products of MSCs such as conditioned environments or extracellular vesicles is a promising direction for using their regenerative potential. However, introduction of MSCs and their secretory products into medical practice requires further research into the mechanisms of their proregenerative action, improvement of cultivation protocols, and more clinical trials.

Bridging the Knowledge Gaps in Arrhythmogenic Cardiovascular Conditions: The Critical Role of Registries

2016 ◽  
Vol 10 (2) ◽  
pp. 1 ◽  
Author(s):  
Melody Hermel ◽  
Rebecca Duffy ◽  
Alexander Orfanos ◽  
Isabelle Hack ◽  
Shayna McEnteggart ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural History ◽  
Risk Stratification ◽  
Critical Role ◽  
Knowledge Gaps ◽  
Level Of Evidence ◽  
The Future

Cardiac registries have filled many gaps in knowledge related to arrhythmogenic cardiovascular conditions. Despite the less robust level of evidence available in registries when compared with clinical trials, registries have contributed a range of clinically useful information. In this review, the authors discuss the role that registries have played – related to diagnosis, natural history, risk stratification, treatment, and genetics of arrhythmogenic cardiovascular conditions – in closing knowledge gaps, and their role in the future.

The role of arterio-venous fistula in formation of pulmonary hypertension in patients on renal replacement therapy. A Review

2019 ◽  
Vol 21 (1) ◽  
pp. 19-31
Author(s):  
R.T. Ishakov ◽  
◽  
E.M. Zeltyn-Abramov ◽  
N.G. Potheshkina ◽  
N.I. Belavina ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Venous Fistula
Sign in / Sign up

Export Citation Format

Share Document