Interactions of pannexin 1 with NMDA and P2X7 receptors in central nervous system pathologies: Possible role on chronic pain

2015 ◽  
Vol 101 ◽  
pp. 86-93 ◽  
Author(s):  
D. Bravo ◽  
C.J. Maturana ◽  
T. Pelissier ◽  
A. Hernández ◽  
L. Constandil
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
P2x7 Receptors ◽  
Pannexin 1

scholarly journals Catastrophizing Interferes with Cognitive Modulation of Pain in Women with Fibromyalgia

Pain Medicine ◽  
2018 ◽  
Vol 19 (12) ◽  
pp. 2408-2422 ◽  
Author(s):  
Laura D Ellingson ◽  
Aaron J Stegner ◽  
Isaac J Schwabacher ◽  
Jacob B Lindheimer ◽  
Dane B Cook
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Pain Catastrophizing ◽  
Pain Modulation ◽  
Critical Function ◽  
Sensory Stimuli ◽  
Brain Responses ◽  
Increased Risk ◽  
Pain Ratings

Abstract Background Pain modulation is a critical function of the nociceptive system that includes the ability to engage descending pain control systems to maintain a functional balance between facilitation and inhibition of incoming sensory stimuli. Dysfunctional pain modulation is associated with increased risk for chronic pain and is characteristic of fibromyalgia (FM). Catastrophizing is also common in FM. However, its influence on pain modulation is poorly understood. Objective To determine the role of catastrophizing on central nervous system processing during pain modulation in FM via examining brain responses and pain sensitivity during an attention-distraction paradigm. Methods Twenty FM patients and 18 healthy controls (CO) underwent functional magnetic resonance imaging while receiving pain stimuli, administered alone and during distracting cognitive tasks. Pain ratings were assessed after each stimulus. Catastrophizing was assessed with the Pain Catastrophizing Scale (PCS). Results The ability to modulate pain during distraction varied among FM patients and was associated with catastrophizing. This was demonstrated by significant positive relationships between PCS scores and pain ratings (P < 0.05) and brain responses in the dorsolateral prefrontal cortex (P < 0.01). Relationships between catastrophizing and pain modulation did not differ between FM and CO (P > 0.05). Conclusions FM patients with higher levels of catastrophizing were less able to distract themselves from pain, indicative of catastrophizing-related impairments in pain modulation. These results suggest that the tendency to catastrophize interacts with attention-resource allocation and may represent a mechanism of chronic pain exacerbation and/or maintenance. Reducing catastrophizing may improve FM symptoms via improving central nervous system regulation of pain.

scholarly journals Nutritional neurobiology and central nervous system sensitisation: missing link in a comprehensive treatment for chronic pain?

2019 ◽  
Vol 123 (5) ◽  
pp. 539-543 ◽  
Author(s):  
Jo Nijs ◽  
Ömer Elma ◽  
Sevilay T. Yilmaz ◽  
Patrick Mullie ◽  
Luc Vanderweeën ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Comprehensive Treatment ◽  
Missing Link

Nutritional intervention in chronic pain: an innovative way of targeting central nervous system sensitization?

2020 ◽  
Vol 24 (8) ◽  
pp. 793-803
Author(s):  
Jo Nijs ◽  
Sevilay Tumkaya Yilmaz ◽  
Ömer Elma ◽  
Joe Tatta ◽  
Patrick Mullie ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Nutritional Intervention ◽  
Central Nervous System Sensitization

SELECTED ASPECTS OF MARTIAL ARTS FOR HEALTH UNDERLYING THEIR PRO-ACTIVE INFLUENCE IN THE CONTEXT OF CENTRAL NERVOUS SYSTEM PLASTICITY

2018 ◽  
Vol 4 ◽  
pp. 46-53
Author(s):  
Tomasz Gora ◽  
Renata Spałek
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Martial Arts ◽  
Brain Structures ◽  
Research Data ◽  
Research Approach ◽  
Martial Art

The aim of this study is to extend the knowledge of selected aspect of  of taekwon-do (martial art)  for health in the context of central nervous system plasticity.  This paper aims at presenting the results of the research and concepts that contribute to the understanding of the value of development and teaching of taekwon-do and other martial arts in the context of the notion of contact. The research data indicate that there are substantial arguments that allow us to state that participation in martial arts  is strictly connected with an integrated activity in different fields of child’s and adolescent’s development. In the case of adults (included patients with musculoskeletal chronic pain) it supports the functioning of the nervous system.  Based on the research approach specified as neuroscience, one can interpret the research reports present in literature, that indicate positive changes in particular brain structures, involved, among others, in the ability to concentrate, as a result of  this training.

scholarly journals Increased Central Nervous System Interleukin-8 in a Majority Postlaminectomy Syndrome Chronic Pain Population

Pain Medicine ◽  
2017 ◽  
Vol 19 (5) ◽  
pp. 1033-1043 ◽  
Author(s):  
Sarah E Giron ◽  
Martin F Bjurstrom ◽  
Charles A Griffis ◽  
F Michael Ferrante ◽  
Irene I Wu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Chronic Pain ◽  
Nervous System ◽  
Growth Factors ◽  
Chronic Pain Patient ◽  
Small Population ◽  
Interleukin 8 ◽  
Pain Patient ◽  
Csf Levels ◽  
Over Time

Abstract Background and Objectives Multiple processes have been identified as potential contributors to chronic pain, with increasing evidence illustrating an association with aberrant levels of neuroimmune mediators. The primary objectives of the present study were to examine central nervous system cytokines, chemokines, and growth factors present in a chronic pain population and to explore patterns of the same mediator molecules over time. Secondary objectives explored the relationship of central and peripheral neuroimmune mediators while examining the levels of anxiety, depression, sleep quality, and perception of pain associated with the chronic pain patient experience. Methods Cerebrospinal fluid (CSF) from a population of majority postlaminectomy syndrome patients (N = 8) was compared with control CSF samples (N = 30) to assess for significant differences in 10 cytokines, chemokines, and growth factors. The patient population was then followed over time, analyzing CSF, plasma, and psychobehavioral measures. Results The present observational study is the first to demonstrate increased mean CSF levels of interleukin-8 (IL-8; P < 0.001) in a small population of majority postlaminectomy syndrome patients, as compared with a control population. Over time in pain patients, CSF levels of IL-8 increased significantly (P < 0.001). Conclusions These data indicate that IL-8 should be further investigated and psychobehavioral components considered in the overall chronic pain paradigm. Future studies examining the interactions between these factors and IL-8 may identify novel targets for treatment of persistent pain states.

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