scholarly journals Comprehensive Hydrolytic Degradation Study of a New Poly(ester-amide) Used for Total Meniscus Replacement

2021 ◽  
pp. 109617
Author(s):  
Catherine E. Miles ◽  
Mariana R.N. Lima ◽  
Fatima Buevich ◽  
Christine Gwin ◽  
N.Sanjeeva Murthy ◽  
...  
Keyword(s):  
Hydrolytic Degradation ◽  
Degradation Study ◽  
Meniscus Replacement

scholarly journals Polymer Membranes Sonocoated and Electrosprayed with Nano-Hydroxyapatite for Periodontal Tissues Regeneration

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1625 ◽  
Author(s):  
Higuchi ◽  
Fortunato ◽  
Woźniak ◽  
Chodara ◽  
Domaschke ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Calcium Release ◽  
Healing Process ◽  
Hydrolytic Degradation ◽  
Clinical Problem ◽  
Degradation Study ◽  
Periodontal Tissues ◽  
Inflammatory Processes ◽  
Cellular Metabolic Activity ◽  
Gradual Release

Diseases of periodontal tissues are a considerable clinical problem, connected with inflammatory processes and bone loss. The healing process often requires reconstruction of lost bone in the periodontal area. For that purpose, various membranes are used to prevent ingrowth of epithelium in the tissue defect and enhance bone regeneration. Currently-used membranes are mainly non-resorbable or are derived from animal tissues. Thus, there is an urgent need for non-animal-derived bioresorbable membranes with tuned resorption rates and porosity optimized for the circulation of body nutrients. We demonstrate membranes produced by the electrospinning of biodegradable polymers (PDLLA/PLGA) coated with nanohydroxyapatite (nHA). The nHA coating was made using two methods: sonocoating and electrospraying of nHA suspensions. In a simulated degradation study, for electrosprayed membranes, short-term calcium release was observed, followed by hydrolytic degradation. Sonocoating produced a well-adhering nHA layer with full coverage of the fibers. The layer slowed the polymer degradation and increased the membrane wettability. Due to gradual release of calcium ions the degradation-associated acidity of the polymer was neutralized. The sonocoated membranes exhibited good cellular metabolic activity responses against MG-63 and BJ cells. The collected results suggest their potential use in Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) periodontal procedures.

Hydrolytic Degradation Study of Dabigatran Etexilate Mesylate: Isolation and Structural Elucidation of New Degradants

2018 ◽  
Vol 8 (3) ◽  
pp. 277-286
Author(s):  
V.V.S.R.N. Anji Karun Mutha ◽  
B.V. Narasimha Raju Katari ◽  
Muralidharan Kaliyaperumal ◽  
Chidananda Swamy Rumalla ◽  
Raghu Babu Korupolu ◽  
...  
Keyword(s):  
Dabigatran Etexilate ◽  
Hydrolytic Degradation ◽  
Structural Elucidation ◽  
Degradation Study

scholarly journals Long-term hydrolytic degradation study of polycaprolactone films and fibers grafted with poly(sodium styrene sulfonate): Mechanism study and cell response

2020 ◽  
Vol 15 (6) ◽  
pp. 061006 ◽  
Author(s):  
Amélie Leroux ◽  
Tuan Ngoc Nguyen ◽  
André Rangel ◽  
Isabelle Cacciapuoti ◽  
Delphine Duprez ◽  
...  
Keyword(s):  
Cell Response ◽  
Hydrolytic Degradation ◽  
Mechanism Study ◽  
Degradation Study ◽  
Styrene Sulfonate ◽  
Sodium Styrene Sulfonate

Hydrolytic degradation study of biodegradable polyesteramide copolymers based on ε-caprolactone and 11-aminoundecanoic acid

Biomaterials ◽  
2004 ◽  
Vol 25 (11) ◽  
pp. 1975-1981 ◽  
Author(s):  
Zhiyong Qian ◽  
Sai Li ◽  
Yi He ◽  
Hailian Zhang ◽  
Xiaobo Liu
Keyword(s):  
Hydrolytic Degradation ◽  
Degradation Study ◽  
Aminoundecanoic Acid

Development of HPLC Method for the Purity Test by Design of Experiments and Determination of Activation Energy of Hydrolytic Degradation Reactions of Sofosbuvir

2020 ◽  
Vol 16 (7) ◽  
pp. 976-987
Author(s):  
Jakub Petřík ◽  
Jakub Heřt ◽  
Pavel Řezanka ◽  
Filip Vymyslický ◽  
Michal Douša
Keyword(s):  
Activation Energy ◽  
Design Of Experiments ◽  
Mobile Phase ◽  
Hydrolytic Degradation ◽  
Isoconversional Method ◽  
Hplc Method ◽  
Organic Modifier ◽  
Calculation Methods ◽  
Degradation Reactions

Background: The present study was focused on the development of HPLC method for purity testing of sofosbuvir by the Design of Experiments and determination of the activation energy of hydrolytic degradation reactions of sofosbuvir using HPLC based on the kinetics of sofosbuvir degradation. Methods: Following four factors for the Design of Experiments were selected, stationary phase, an organic modifier of the mobile phase, column temperature and pH of the mobile phase. These factors were examined in two or three level experimental design using Modde 11.0 (Umetrics) software. The chromatographic parameters like resolution, USP tailing and discrimination factor were calculated and analysed by partial least squares. The chromatography was performed based on Design of Experiments results with the mobile phase containing ammonium phosphate buffer pH 2.5 and methanol as an organic modifier. Separation was achieved using gradient elution on XBridge BEH C8 at 50 °C and a flow rate of 0.8 mL/min. UV detection was performed at 220 nm. The activation energy of hydrolytic degradation reactions of sofosbuvir was evaluated using two different calculation methods. The first method is based on the slope of dependence of natural logarithm of the rate constant on inverted thermodynamic temperature and the second approach is the isoconversional method. Results and Conclusion: Calculated activation energies were 77.9 ± 1.1 kJ/mol for the first method and 79.5 ± 3.2 kJ/mol for the isoconversional method. The results can be considered to be identical, therefore both calculation methods are suitable for the determination of the activation energy of degradation reactions.

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