scholarly journals Development and optimization of ciprofloxacin-loaded gelatin microparticles by single-step spray-drying technique

2018 ◽  
Vol 330 ◽  
pp. 201-209 ◽  
Author(s):  
Dina M. Silva ◽  
Heema Kumari Nilesh Vyas ◽  
Martina L. Sanderson-Smith ◽  
Vitor Sencadas
Keyword(s):  
Spray Drying ◽  
Single Step ◽  
Gelatin Microparticles

Densification process of silica microspheres by multi-step sintering

2019 ◽  
Vol 9 (5) ◽  
pp. 529-534 ◽  
Author(s):  
Xiaolin Zhang
Keyword(s):  
Sinter Temperature ◽  
Relative Density ◽  
Spray Drying ◽  
Temperature Increase ◽  
Single Step ◽  
Silica Spheres ◽  
Densification Process ◽  
Silica Microspheres ◽  
Step Process ◽  
Sinter Temperature Increase

Dense silica microspheres were fabricated by spray drying and multi-step sintering. The effect of sinter temperatures on densification, dispersibility and inner morphology of silica spheres was analyzed by SEM, and the densification process was deeply discussed. The results showed that single-step sintering at 1100 °C made silica spheres seriously coherent each other and spherical morphology irregular. However, a multi-step process made the sinter temperature increase to 1190 °C, while silica spheres still kept uniformly spherical and dispersed. The increased temperature resulted in that the silica particles obtained dense inner morphology, and their density reached 2.18 g · cm–3, corresponding to a relative density of 98.6% (in comparison with the density of 2.21 g · cm–3 for noncrystal silica).

scholarly journals Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems

2020 ◽  
Vol 10 (20) ◽  
pp. 7109
Author(s):  
Adam Pacławski ◽  
Jakub Szlęk ◽  
Renata Jachowicz ◽  
Stefano Giovagnoli ◽  
Barbara Wiśniowska ◽  
...  
Keyword(s):  
Evolutionary Algorithms ◽  
Spray Drying ◽  
Particle Interaction ◽  
Predictive Ability ◽  
Single Step ◽  
Coefficient Of Determination ◽  
Drying Process ◽  
Formulation Development ◽  
Aerodynamic Properties

Spray drying is a single step process in which solutions or dispersions are converted into dry particles. It is widely used in pharmaceutical technology to produce inhalable particles. Dry particle behavior during inhalation, described as the emitted dose (ED) and fine particle fraction (FPF), is determined in vitro by standardized procedures. A large number of factors influencing the spray drying process and particle interaction makes it difficult to predict the final product properties in advance. This work presents the development of predictive models based on experimental data obtained by aerodynamic assessment of respirable dry powders. Developed models were tested according to the 10-fold cross-validation procedure and yielded good predictive ability. Both models were characterized by normalized root-mean-square error (NRMSE) below 8.50% and coefficient of determination (R2) above 0.90. Moreover, models were analyzed to establish a relationship between spray drying process parameters and the final product quality measures. Presented work describes the strategy of implementing the evolutionary algorithms in empirical model’s development. Obtained models can be applied as an expert system during pharmaceutical formulation development. The models have the potential for product optimization and a knowledge extraction to improve final quality of the drug.

scholarly journals Uniform Chitosan Microparticles Prepared by a Novel Spray-Drying Technique

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Wenjie Liu ◽  
Winston Duo Wu ◽  
Cordelia Selomulya ◽  
Xiao Dong Chen
Keyword(s):  
Particle Size ◽  
Spray Drying ◽  
Storage Time ◽  
Particle Morphology ◽  
Surface Characteristics ◽  
Single Step ◽  
Drying Temperature ◽  
Chitosan Microparticles ◽  
Particle Size And Morphology ◽  
Size And Morphology

Particle size and morphology are important properties of pharmaceutical particles. Preparation of microparticles with uniform particle size and morphology is necessary in order to systematically relate these properties to the release behavior and other functionalities such as drug encapsulation and dissolution. In this study, we successfully prepared monodisperse, nonagglomerated chitosan microparticles in a single step by a novel spray-drying technique. The control of particle size and morphology of spray-dried microparticles was investigated experimentally. Microparticles with larger particle size can be produced when chitosan precursor of higher concentration was used. Storage time of chitosan precursor, drying temperature, and addition of lactose were shown to be crucial parameters that affect the particle morphology. Appropriate choice of the drying temperature and precursor storage time permitted control of the particle morphology, ranging from nearly spherical to cap-shaped. Surface characteristics of the particles can be finely tuned by the amount of lactose added into the chitosan precursor.

Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization

2003 ◽  
Vol 264 (1-2) ◽  
pp. 45-55 ◽  
Author(s):  
M.L Bruschi ◽  
M.L.C Cardoso ◽  
M.B Lucchesi ◽  
M.P.D Gremião
Keyword(s):  
Spray Drying ◽  
Gelatin Microparticles

scholarly journals Applicability of Spray Drying Technique to Prepare Nano-Micro Carriers: A Review

2021 ◽  
pp. 33-45
Author(s):  
Archana Mishra ◽  
Jitendra Kumar ◽  
Kuber Chandra Bhainsa
Keyword(s):  
Heavy Metals ◽  
Spray Drying ◽  
Food Industry ◽  
Single Step ◽  
Environment Friendly ◽  
Research Areas ◽  
Wide Range ◽  
Drying Techniques ◽  
Recent Developments ◽  
Spray Dried

Nano-micro carriers loaded with drugs and active biomolecules have gained a lot of attention in the field of health care, agriculture, and the food industry. Various methods have been explored to synthesize nano-micro carriers. However, there is still a constant search to develop a method for the preparation of a large quantity of nano-micro carriers with high loading efficiency. In this regard, spray drying could be a potential technique because of its inherent features like ease to operate, cost-effectiveness, environment-friendly, single step, and scalable. In this review, the focus is on the applicability of spray drying technique to prepare nano-micro carriers which are loaded with drugs, microorganisms, and other active molecules. Subsequently, the application and usefulness of spray-dried products in different research areas like the food industry, remediation of heavy metals and bioprocessing, and drug delivery have been presented. Furthermore, advantages, limitations, and recent developments in the area of spray drying have been discussed. This review presents a glimpse of spray drying techniques to synthesize nano-micro carriers with a wide range of applications.

V884: Demonstration of a Novel Single-Step Percutaneous Access Sheath for Nephrostolithotomy: A Video Presentation

2005 ◽  
Vol 173 (4S) ◽  
pp. 240-240
Author(s):  
Premal J. Desai ◽  
David A. Hadley ◽  
Lincoln J. Maynes ◽  
D. Duane Baldwin
Keyword(s):  
Single Step ◽  
Video Presentation ◽  
Percutaneous Access ◽  
Access Sheath

Effect of Lipoprotein(a) and LDL on Plasminogen Binding to Extracellular Matrix and on Matrix-dependent Plasminogen Activation by Tissue Plasminogen Activator

1996 ◽  
Vol 75 (03) ◽  
pp. 497-502 ◽  
Author(s):  
Hadewijch L M Pekelharing ◽  
Henne A Kleinveld ◽  
Pieter F C.C.M Duif ◽  
Bonno N Bouma ◽  
Herman J M van Rijn
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Plasminogen Activator ◽  
Binding Sites ◽  
Umbilical Vein ◽  
Single Step ◽  
Plasminogen Activation ◽  
Structural Homology ◽  
Tissue Plasminogen ◽  
Umbilical Vein Endothelial Cells

SummaryLp(a) is an LDL-like lipoprotein plus an additional apolipoprotein apo(a). Based on the structural homology of apo(a) with plasminogen, it is hypothesized that Lp(a) interferes with fibrinolysis. Extracellular matrix (ECM) produced by human umbilical vein endothelial cells was used to study the effect of Lp(a) and LDL on plasminogen binding and activation. Both lipoproteins were isolated from the same plasma in a single step. Plasminogen bound to ECM via its lysine binding sites. Lp(a) as well as LDL were capable of competing with plasminogen binding. The degree of inhibition was dependent on the lipoprotein donor as well as the ECM donor. When Lp(a) and LDL obtained from one donor were compared, Lp(a) was always a much more potent competitor. The effect of both lipoproteins on plasminogen binding was reflected in their effect on plasminogen activation. It is speculated that Lp(a) interacts with ECM via its LDL-like lipoprotein moiety as well as via its apo(a) moiety.

Sign in / Sign up

Export Citation Format

Share Document