72 Pregnancy associated plasma protein-A and placental growth factor in a sub-Saharan African population: A nested cross-sectional study

Indroduction: Miscarriage is the most common complication of pregnancy. Defective implantation is one of the common causes of miscarriage. Pregnancy Associated Plasma Protein-A (PAPP-A) is secreted from syncytiotrophoblast and it enables trophoblast invasion. Few studies have shown association of PAPP-A with miscarriage. However, there is limited data available to establish the role of PAPP-A as a predictive marker of miscarriage, especially in Indian population. Aim: To determine the potential of maternal PAPP-A level estimation in asymptomatic women in late first trimester (10-13 weeks) with viable foetus in predicting subsequent miscarriage. Materials and Methods: This was an observational, cross-sectional study conducted from November 2016 to April 2018 at University College of Medical Science and Guru Teg Bahadur Hospital, Delhi, India. Asymptomatic pregnant women (N=500) at 10-13 weeks of gestation were recruited from an antenatal clinic after confirmation of foetal viability. A 2 mL of blood sample was collected and serum PAPP-A level was measured. Independent t-test and Chi-square test was used to compare continuous data and Mann-Whitney U test was used to compare PAPP-A Multiple of Median (MOM). Logistic regression was used to estimate risk of miscarriage. Results: Out of 500 participants, 9 were lost to follow-up. From remaining N=491, 32 (6.5%) women had a miscarriage. PAPP-A levels were significantly decreased in miscarriage group compared to ongoing pregnancy group with median MOM 0.116 (0.080-0.17) and 1.25 (0.665-3.249) respectively (p-value <0.001). PAPP-A MOM value of ≤10th percentile sensitivity and specificity of detection of miscarriage was 81.25% and 94.98% and at ≤5th percentile sensitivity and specificity was 40.62% and 97.82%, respectively. Lower the percentile cut-off of serum PAPP-A value, higher was the specificity and positive predictive value for prediction of miscarriage. By applying logistic regression we found that if PAPP-A MOM decreases by 1 unit the chances of miscarriage increased by 1.2 times. By this model 63.2% of cases could be explained (Nagelkerke R Square=0.632). For prediction of pregnancies likely to miscarry, the area under Receiver Operator Characteristic (ROC) curve (95% CI) was 0.969 (0.955-0.983). Conclusion: Low serum PAPP-A levels from asymptomatic women in late 1st trimester is a good predictive marker of miscarriage.

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Evaluation of the accuracy of two point-of-care haemoglobin meters used in sub-Saharan African population: a cross-sectional study

BMC Cardiovascular Disorders ◽

10.1186/s12872-020-01371-x ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Simeon-Pierre Choukem ◽

Colette Sih ◽

Akondu Tontu Ntumsi ◽

Christian Akem Dimala ◽

Yannick Mboue-Djieka ◽

...

Keyword(s):

Point Of Care ◽

Cross Sectional Study ◽

African Population ◽

Sectional Study ◽

Cross Sectional ◽

Sub Saharan

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P 16 Cross sectional study of placental growth factor in multiple pregnancy

Pregnancy Hypertension ◽

10.1016/j.preghy.2017.07.094 ◽

2017 ◽

Vol 9 ◽

pp. 44

Author(s):

Deirdre Hayes Ryan ◽

Ainhoa Totorika ◽

Cathal McCarthy ◽

Aisling Doyle ◽

Emma Snapes ◽

...

Keyword(s):

Growth Factor ◽

Multiple Pregnancy ◽

Cross Sectional Study ◽

Placental Growth Factor ◽

Sectional Study ◽

Cross Sectional ◽

P 16

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Maternal healthcare utilsation and complete childhood vaccination in sub-Saharan Africa: a cross-sectional study of 29 nationally representative surveys

BMJ Open ◽

10.1136/bmjopen-2020-045992 ◽

2021 ◽

Vol 11 (5) ◽

pp. e045992

Author(s):

Eugene Budu ◽

Bright Opoku Ahinkorah ◽

Richard Gyan Aboagye ◽

Ebenezer Kwesi Armah-Ansah ◽

Abdul-Aziz Seidu ◽

...

Keyword(s):

Healthcare Utilisation ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Childhood Vaccination ◽

Outcome Variable ◽

Service Utilisation ◽

Sectional Study ◽

Maternal Healthcare ◽

Cross Sectional ◽

Sub Saharan

ObjectiveThe objective of the study was to examine the association between maternal healthcare utilisation and complete childhood vaccination in sub-Saharan Africa.DesignOur study was a cross-sectional study that used pooled data from 29 countries in sub-Saharan Africa.ParticipantsA total of 60 964 mothers of children aged 11–23 months were included in the study.Outcome variablesThe main outcome variable was complete childhood vaccination. The explanatory variables were number of antenatal care (ANC) visits, assistance during delivery and postnatal care (PNC).ResultsThe average prevalence of complete childhood vaccination was 85.6%, ranging from 67.0% in Ethiopia to 98.5% in Namibia. Our adjusted model, children whose mothers had a maximum of three ANC visits were 56% less likely to have complete vaccination, compared with those who had at least four ANC visits (adjusted OR (aOR)=0.44, 95% CI 0.42 to 0.46). Children whose mothers were assisted by traditional birth attendant/other (aOR=0.43, 95% CI 0.41 to 0.56) had lower odds of complete vaccination. The odds of complete vaccination were lower among children whose mothers did not attend PNC clinics (aOR=0.26, 95% CI 0.24 to 0.29) as against those whose mothers attended.ConclusionThe study found significant variations in complete childhood vaccination across countries in sub-Saharan Africa. Maternal healthcare utilisation (ANC visits, skilled birth delivery, PNC attendance) had significant association with complete childhood vaccination. These findings suggest that programmes, interventions and strategies aimed at improving vaccination should incorporate interventions that can enhance maternal healthcare utilisation. Such interventions can include education and sensitisation, reducing cost of maternal healthcare and encouraging male involvement in maternal healthcare service utilisation.

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Routine first‐trimester combined screening for pre‐eclampsia: pregnancy‐associated plasma protein‐A or placental growth factor?

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.23669 ◽

2021 ◽

Author(s):

L. Nöel ◽

G. P. Guy ◽

S. Jones ◽

K. Forenc ◽

E. Buck ◽

...

Keyword(s):

Growth Factor ◽

Plasma Protein ◽

Protein A ◽

First Trimester ◽

Placental Growth Factor

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Predictors of HIV Testing among Youth in Sub-Saharan Africa: A Cross-Sectional Study

PLoS ONE ◽

10.1371/journal.pone.0164052 ◽

2016 ◽

Vol 11 (10) ◽

pp. e0164052 ◽

Cited By ~ 30

Author(s):

Ibitola O. Asaolu ◽

Jayleen K. Gunn ◽

Katherine E. Center ◽

Mary P. Koss ◽

Juliet I. Iwelunmor ◽

...

Keyword(s):

Hiv Testing ◽

Cross Sectional Study ◽

Sub Saharan Africa ◽

Sectional Study ◽

Cross Sectional ◽

Sub Saharan

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Childhood Diarrhea Determinants in Sub-Saharan Africa: A Cross Sectional Study of Tiko-Cameroon

Challenges ◽

10.3390/challe6020229 ◽

2015 ◽

Vol 6 (2) ◽

pp. 229-243 ◽

Cited By ~ 13

Author(s):

Ayuk Tambe ◽

Leonie Nzefa ◽

Nchang Nicoline

Keyword(s):

Cross Sectional Study ◽

Sub Saharan Africa ◽

Sectional Study ◽

Childhood Diarrhea ◽

Cross Sectional ◽

Sub Saharan

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DOES INSULIN LIKE GROWTH FACTOR-1 (IGF-1) DEFICIENCY HAVE A “PROTECTIVE” ROLE IN THE DEVELOPMENT OF DIABETIC RETINOPATHY IN THALASSEMIA MAJOR PATIENTS?

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2015.038 ◽

2015 ◽

Vol 7 ◽

pp. e2015038 ◽

Cited By ~ 4

Author(s):

Vincenzo De Sanctis

Keyword(s):

Diabetic Retinopathy ◽

Growth Factor ◽

Cross Sectional Study ◽

Protective Role ◽

Dependent Diabetes Mellitus ◽

Diabetic Patients ◽

Italian Population ◽

Sectional Study ◽

Cross Sectional ◽

Number Of Patients

Objective: This cross-sectional study was designed to give insights into relationship between Insulin-Growth-Factor 1 (IGF-1) levels and diabetic retinopathy (DR) in a sample of thalassaemia major(TM) patients with insulin dependent diabetes mellitus (IDDM). Τhis relation was not previously evaluated, despite the fact that both diseases co-exist in the same patient. The study also describes the clinical and biochemical profile of the associated complications in TM patients with and without IDDM. Design: A population-based cross-sectional study. Participants:The study includes 19 consecutive TM patients with IDDM and 31 age- and sex-matched TM patients without IDDM who visited our out-patient clinics for an endocrine assessment Methods: An extensive medical history, with data on associated complications and current medications, was obtained. Blood samples were drawn in the morning after an overnight fast to measure the serum concentrations of IGF-1, glucose, fructosamine , free thyroxine (FT4), thyrotropin (TSH) and biochemical analysis . Serologic screening assays for hepatitis C virus seropositivity (HCVab and HCV-RNA) were also evaluated, applying routine laboratory methods.Plasma total IGF-1 was measured by a chemiluminescent immunometric assay (CLIA) method. Ophthalmology evaluation was done by the same researcher using stereoscopic fundus biomicroscopy through dilated pupils. DR was graded using the scale developed by the Global Diabetic Retinopathy Group. Iron stores were assessed by direct and indirect methods. Results:Eighteen TM patients with IDDM (94.7 %) and 10 non-diabetic patients (32.2 %) had IGF-1 levels below the 2.5th percentile of the normal values for the Italian population. The mean serum IGF-1 concentrations were significantly lower in the diabetic versus the non-diabetic TM groups (p < 0.001). DR was present in in 4 (21 %) of 19 TM patients with IDDM and was associated with the main classical risk factors, namely inefficient glycemic control and duration of disease but not hypertension. Using the scale developed by the Global Diabetic Retinopathy Group, the DR in our patients was classified as non proliferative diabetic retinopathy (NPDR). Only few numbers of microaneurysms [1-3] were detected. Our data also confirm the strong association of IDDM in TM patients with other endocrine and non-endocrine complications.Conclusions: These results , although on a small number of patients, suggest a possible ‘protective’ role of low IGF-1 in the development of DR in TM patients

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