Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and its potential role in the pregnancy complications

2020 ◽  
Vol 19 ◽  
pp. 159-168 ◽  
Author(s):  
Zain Awamleh ◽  
Victor K.M. Han
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Potential Role ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Human Placentae

Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia

2018 ◽  
Vol 45 (9) ◽  
pp. 1263-1272 ◽  
Author(s):  
Valentina Canti ◽  
Stefania Del Rosso ◽  
Marta Tonello ◽  
Roberta Lucianò ◽  
Ariela Hoxha ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Late Pregnancy ◽  
Additional Treatment ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Thrombotic Risk ◽  
Intrauterine Growth

Objective.Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS).Methods.We enrolled 55 patients with APS who were seeking pregnancy in 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, lupus-like anticoagulant, and aPS/PT antibodies were assessed, and the patients were prospectively followed for 24 months.Results.There were 65% (36/55) of the APS patients who had aPS/PT antibodies. Forty-seven pregnancies were followed, including 33 of aPS/PT+ patients. Forty-one of the 47 patients (87%) who initiated a pregnancy eventually gave birth to a child. The pregnancy duration and the mean newborn weight at delivery were significantly lower in aPS/PT+ than in aPS/PT− patients (33.1 ± 4.7 vs 36.2 ± 3.4 wks of gestation, respectively, and 2058 ± 964 g vs 2784 ± 746 g, respectively, p < 0.05). Late pregnancy complications, including intrauterine fetal death, preterm delivery, preeclampsia, and intrauterine growth restriction (IUGR), were more frequent in aPS/PT+ patients, independent of the therapy. Titers of aPS/PT IgG were significantly inversely correlated with the neonatal weight at delivery. Vascular injury, as reflected by thrombosis, fibrinoid necrosis, ischemic and hemorrhagic areas, and presence of chorangiomas characterized the IUGR placentas in the presence of aPS/PT.Conclusion.The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, IUGR/preeclampsia in particular, and could help identify beforehand patients who may require additional treatment.

scholarly journals Selenium is a functional component of the female reproductive system. Its role in pregnancy complications

2021 ◽  
Vol 4 (4) ◽  
pp. 328-332
Author(s):  
G.K. Sadykova ◽  
◽  
A.A. Olina ◽  
◽  
Keyword(s):  
Reproductive System ◽  
Pregnancy Complications ◽  
Premature Birth ◽  
Intrauterine Growth Restriction ◽  
Placental Insufficiency ◽  
Growth Restriction ◽  
Female Reproductive System ◽  
Functional Component ◽  
Intrauterine Growth ◽  
In Pregnancy

This paper reviews studies on selenium (Se) in human reproduction. Low Se intake is associated with the development of gestational hypertension, miscarriage, premature birth, intrauterine growth restriction, and thyroid gland dysfunction. Therefore, studies on the association between Se deficiency and impaired folliculogenesis, steroidogenesis, and infertility in women are of great interest. Unfortunately, these studies are scarce, and further studies are needed. A significant antioxidant activity of Se-containing enzymes allows for minimizing risks of obstetrical complications associated with placental insufficiency. Therefore, selenium is vital for realizing female reproductive function. However, even given potential risks of insufficient Se-containing product intake, the authors find it unacceptable to recommend Se dotation in the population since toxic effects of Se excess are yet to be fully explored. Further studies on Se biological effects will extend the scope of its use in obstetrics and gynecology in terms of a preventive approach. KEYWORDS: selenium, placental insufficiency, folliculogenesis, steroidogenesis, antioxidant, miscarriage, premature birth, intrauterine growth restriction. FOR CITATION: Sadykova G.K., Olina A.A. Selenium is a functional component of the female reproductive system. Its role in pregnancy complications. Russian Journal of Woman and Child Health. 2021;4(4):328–332 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4- 328-332.

Altered gene expression patterns in intrauterine growth restriction: Potential role of hypoxia

2007 ◽  
Vol 196 (1) ◽  
pp. 70.e1-70.e6 ◽  
Author(s):  
Cathal McCarthy ◽  
Finbarr E. Cotter ◽  
Suzanne McElwaine ◽  
Anne Twomey ◽  
Eoghan E. Mooney ◽  
...  
Keyword(s):  
Gene Expression ◽  
Intrauterine Growth Restriction ◽  
Potential Role ◽  
Expression Patterns ◽  
Growth Restriction ◽  
Gene Expression Patterns ◽  
Intrauterine Growth ◽  
Altered Gene Expression ◽  
Altered Gene

scholarly journals Prediction of Preeclampsia and Intrauterine Growth Restriction in Low-risk Pregnancies in East Avenue Medical Center using Uterine Artery Doppler Velocimetry

2019 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Blood Pressure ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Uterine Artery ◽  
Growth Restriction ◽  
Doppler Velocimetry ◽  
Uterine Artery Doppler ◽  
Intrauterine Growth ◽  
Adverse Pregnancy

Preeclampsia, which is defined as elevated blood pressure after 20 weeks of pregnancy in a woman whose blood pressure had been normal, remains the second most common cause of direct maternal deaths (0.83 per 100,000 cases) worldwide. At present, no effective prophylactic measures have been identified in the prevention of preeclampsia and other pregnancy complications such as intrauterine growth restriction. Therefore, proper antenatal care remains the most important part of prevention. Identifying each woman’s individualized risk can allow further antenatal surveillance to be directed to those women who are most likely to develop preeclampsia. Such care leads to early diagnosis and intervention, both in terms of maternal/ fetal monitoring and timing of delivery. In this study, uterine artery Doppler velocimetry in the mid-trimester will be analyzed, and its role in the prediction of later pregnancy complications (preeclampsia and intrauterine growth restriction) will be discussed. The aim of this study is to predict the risk for the development of adverse pregnancy outcomes on the basis of mid-trimester uterine artery Doppler velocimetry. Statistical analysis showed that preeclampsia occurred significantly more commonly in the group with an abnormal doppler result at 16-22 weeks of gestation, compared to pregnancies with normal doppler findings. That is 42.9% (3 out of 7) for abnormal doppler result versus 7.2% (2 out of 27) for those with normal doppler findings. However, none of the 34 evaluated cases developed intrauterine growth restriction. Abnormal uterine artery Doppler result at 16-22 weeks is associated with adverse pregnancy outcomes. In this study, it was well correlated with the development of preeclampsia. Hence, uterine artery Doppler can be used as a useful method for identifying high-risk pregnancies. Uterine artery pulsatility index (PI >1.45) can provide further information for the prediction of preeclampsia in order to conduct appropriate clinical interventions to avoid perinatal morbidity

161. PATERNAL AND FETAL SINGLE NUCLEOTIDE POLYMORPHISMS IN KDR GENE ASSOCIATE WITH PREECLAMPSIA AND INTRAUTERINE GROWTH RESTRICTION

2009 ◽  
Vol 21 (9) ◽  
pp. 79
Author(s):  
P. H. Andraweera ◽  
S. D. Thompson ◽  
R. C. Nowak ◽  
V. J. Zhang ◽  
G. A. Dekker ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Neonatal Morbidity ◽  
Growth Restriction ◽  
Angiogenic Factor ◽  
Nucleotide Polymorphisms ◽  
Chi Square ◽  
Ongoing Research ◽  
Intrauterine Growth ◽  
Placental Angiogenesis

Introduction: Preeclampsia (PE) and intrauterine growth restriction (IUGR) together contribute to maternal and neonatal morbidity and mortality. Abnormal placental angiogenesis is implicated in these pregnancy complications. KDR is the main receptor for vascular endothelial growth factor, a potent angiogenic factor which regulates placental angiogenesis. Derangements in KDR expression are known to result in abnormal angiogenesis. We aimed to determine whether polymorphisms in KDR gene (KDR T604C and KDR C1192C) are associated with PE and IUGR. Methods: 1169 nulliparous pregnant women and their partners were recruited prospectively at the Lyell McEwin Hospital and women monitored throughout pregnancy. PE and IUGR were classified using strict guidelines. Uncomplicated pregnancies were deemed controls. Peripheral blood was collected from couples and cord blood collected at delivery. DNA extraction from buffy coats and genotyping were performed at the Australian Genome Research Facility using the Sequenom MassARRAY system. Genotypes for PE (n=63) and IUGR (n=94) were compared with controls (n=373) and analysed using ANOVA and Chi Square. Odds Ratios (OR) were calculated. Results: Paternal and neonatal KDR T604C were associated with PE (p=0.028, OR=1.9, 95%CI=1.08–3.34 and p=0.008, OR=2.5, 95%CI=1.3–4.78). Paternal and neonatal KDR T604C were associated with IUGR (p=0.005, OR=2.01, 95%CI=1.24–3.25 and p=0.01, OR=1.15, 95% CI=1.22–3.79). Neonates with KDR T604C CC genotype were 144.5g lighter than those with the TT genotype (p=0.05). Mean customised birth weight centile was 8.7 lower for fathers with KDR T604C CC genotype compared to CT (p=0.041). KDR C1192T SNP was not associated with outcome. Conclusion: Our results suggest that KDR T604C polymorphism is associated with both PE and IUGR. We are the first to demonstrate an association between paternal KDR polymorphisms and pregnancy complications. Paternal genes acting via the placenta appear to contribute to the risk of PE and IUGR. Ongoing research will determine the role of these polymorphisms in placental angiogenesis.

Pregnancy complications

2017 ◽  
Author(s):  
Janet Medforth ◽  
Linda Ball ◽  
Angela Walker ◽  
Sue Battersby ◽  
Sarah Stables
Keyword(s):  
Early Pregnancy ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Multiple Pregnancy ◽  
Breech Presentation ◽  
Signs And Symptoms ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Management Plans ◽  
Antenatal Management

The chapter is concerned with recognition and the most recent guidance on the management of commonly seen pregnancy complications. These include early pregnancy bleeding, antepartum haemorrhage, hyperemesis, obstetric cholestasis, multiple pregnancy, breech presentation, intrauterine growth restriction, thromboembolic disorders, and the principles of thromboprophylaxis. Each section describes the condition and factors that may lead to its development. Signs and symptoms are described, along with contraindications and aspects of treatment. Special considerations in the antenatal management plans are included.

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