SY2-1. Enhanced adenosine signaling in the placenta: a crucial pathogenic factor and a possible therapeutic target for preeclampsia

The review summarizes current idea on the key role of interleukin 6 (IL-6) in the pathogenesis of rheumatic diseases (RDs) and depressive disorders. It considers in detail the mechanisms by which IL6 induces the clinical and laboratory manifestations of RDs and depression; the influence of precipitating and predisposing stress factors, including childhood mental traumas, which increase the risk of RDs and depression, on IL-6 production. Particular attention is paid to the consideration of prospects for using IL-6 inhibitors in the therapy of depression.

Download Full-text

Elevated ecto-5′-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease

Blood Advances ◽

10.1182/bloodadvances.2018015784 ◽

2018 ◽

Vol 2 (15) ◽

pp. 1957-1968 ◽

Cited By ~ 6

Author(s):

Hong Liu ◽

Morayo Adebiyi ◽

Rong Rong Liu ◽

Anren Song ◽

Jeanne Manalo ◽

...

Keyword(s):

Sickle Cell Disease ◽

Disease Severity ◽

Sickle Cell ◽

Therapeutic Target ◽

Therapeutic Strategy ◽

Specific Inhibition ◽

Pathogenic Factor ◽

Cell Disease ◽

Key Points ◽

Novel Therapeutic

Key Points CD73-mediated adenosine production contributes to SCD pathogenesis by promoting erythrocyte 2,3-BPG production and sickling. Specific inhibition of CD73 significantly attenuates disease severity of SCD mice and provides a novel therapeutic strategy to treat SCD.

Download Full-text

Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate

Journal of Biomedical Science ◽

10.1186/s12929-018-0462-0 ◽

2018 ◽

Vol 25 (1) ◽

Cited By ~ 20

Author(s):

Hong-Ru Chen ◽

Yen-Chung Lai ◽

Trai-Ming Yeh

Keyword(s):

Dengue Virus ◽

Therapeutic Target ◽

Vaccine Candidate ◽

Pathogenic Factor ◽

Structural Protein

Download Full-text

Memapsin 2, a drug target for Alzheimer's disease

Biochemical Society Symposium ◽

10.1042/bss0700213 ◽

2003 ◽

Vol 70 ◽

pp. 213-220 ◽

Cited By ~ 1

Author(s):

Gerald Koelsch ◽

Robert T. Turner ◽

Lin Hong ◽

Arun K. Ghosh ◽

Jordan Tang

Keyword(s):

Crystal Structure ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Transition State ◽

Amyloid Precursor Protein ◽

Therapeutic Target ◽

Drug Target ◽

Aspartic Protease ◽

Precursor Protein ◽

Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

Download Full-text