SY2-1. Enhanced adenosine signaling in the placenta: a crucial pathogenic factor and a possible therapeutic target for preeclampsia

2021 ◽  
Vol 25 ◽  
pp. e4
Author(s):  
Takayuki Iriyama
Keyword(s):  
Therapeutic Target ◽  
Pathogenic Factor ◽  
Adenosine Signaling

scholarly journals Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss

2020 ◽  
Vol 34 (12) ◽  
pp. 15771-15787 ◽  
Author(s):  
Jeanne M. Manalo ◽  
Hong Liu ◽  
Dalian Ding ◽  
John Hicks ◽  
Hong Sun ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Therapeutic Target ◽  
Sensorineural Hearing ◽  
Pathogenic Factor ◽  
Adenosine A2b Receptor ◽  
A2b Receptor ◽  
Adenosine A2b

Abstract PL05-02: MMSET: A pathogenic factor and therapeutic target in multiple myeloma.

2011 ◽  
Author(s):  
Jonathan D. Licht ◽  
Relja Popovic ◽  
Dong-Joon Min ◽  
Eva Martinez-Garcia ◽  
Milan Mrksch ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Therapeutic Target ◽  
Pathogenic Factor

scholarly journals Interleukin 6 as a pathogenic factor mediating clinical manifestations and a therapeutic target for rheumatic diseases and depressive disorders

2019 ◽  
Vol 57 (3) ◽  
pp. 318-327 ◽  
Author(s):  
T. A. Lisitsyna ◽  
D. Yu. Veltishchev ◽  
A. M. Lila ◽  
E. L. Nasonov
Keyword(s):  
Rheumatic Diseases ◽  
Interleukin 6 ◽  
Therapeutic Target ◽  
Depressive Disorders ◽  
Clinical Manifestations ◽  
Stress Factors ◽  
Current Idea ◽  
Pathogenic Factor

The review summarizes current idea on the key role of interleukin 6 (IL-6) in the pathogenesis of rheumatic diseases (RDs) and depressive disorders. It considers in detail the mechanisms by which IL6 induces the clinical and laboratory manifestations of RDs and depression; the influence of precipitating and predisposing stress factors, including childhood mental traumas, which increase the risk of RDs and depression, on IL-6 production. Particular attention is paid to the consideration of prospects for using IL-6 inhibitors in the therapy of depression.

scholarly journals Elevated ecto-5′-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease

2018 ◽  
Vol 2 (15) ◽  
pp. 1957-1968 ◽  
Author(s):  
Hong Liu ◽  
Morayo Adebiyi ◽  
Rong Rong Liu ◽  
Anren Song ◽  
Jeanne Manalo ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Disease Severity ◽  
Sickle Cell ◽  
Therapeutic Target ◽  
Therapeutic Strategy ◽  
Specific Inhibition ◽  
Pathogenic Factor ◽  
Cell Disease ◽  
Key Points ◽  
Novel Therapeutic

Key Points CD73-mediated adenosine production contributes to SCD pathogenesis by promoting erythrocyte 2,3-BPG production and sickling. Specific inhibition of CD73 significantly attenuates disease severity of SCD mice and provides a novel therapeutic strategy to treat SCD.

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

COX–2 is overesxpressed in ovarian endometriosis and might represent a therapeutic target

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
A Meinel ◽  
C Leo ◽  
G Zimmermann ◽  
H Alexander ◽  
LC Horn
Keyword(s):  
Therapeutic Target ◽  
Ovarian Endometriosis ◽  
Cox 2
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