The neurocognitive and functional profile of schizophrenia in a genetically homogenous European sample

2021 ◽  
pp. 114140
Author(s):  
Carolina da Motta ◽  
Michele T. Pato ◽  
Célia Barreto Carvalho ◽  
Paula Castilho
Keyword(s):  
Functional Profile

Somatic and functional profile of sport rock climbers

2008 ◽  
Vol 52 (-1) ◽  
pp. 73-76 ◽  
Author(s):  
André Padrenosso ◽  
Erik S. de Godoy ◽  
Eurico César ◽  
Ana Barreto ◽  
Vitor Reis ◽  
...  
Keyword(s):  
Functional Profile

scholarly journals A Little Something Goes a Long Way: Little in the Old Bailey Corpus

2021 ◽  
pp. 007542422098206
Author(s):  
Claudia Claridge ◽  
Ewa Jonsson ◽  
Merja Kytö
Keyword(s):  
Good Deal ◽  
Functional Profile ◽  
Prepositional Phrases ◽  
Related Data ◽  
The Past ◽  
Wide Range ◽  
Old Bailey ◽  
Version 2.0 ◽  
Data Source ◽  
Late Modern

Even though intensifiers have received a good deal of attention over the past few decades, downtoners, comprising diminishers and minimizers, have remained by and large a neglected category (but cf. Brinton, this issue). Among downtoners, the adverb little or a little stands out as the most frequent item. It is multifunctional and serves as a diminishing and minimizing intensifier and also in non-degree uses as a quantifier, frequentative, and durative. Therefore, the present paper is devoted to the structural and functional profile of ( a) little in Late Modern English speech-related data. The data source is the socio-pragmatically annotated Old Bailey Corpus (OBC, version 2.0), which allows, among other things, the investigation of the usage of the item among different speaker groups. Our research charts the semantic and formal uses of adverbial little. Downtoner uses outnumber non-degree uses in the data, and diminishing uses are more common than minimizing uses. The formal realization is predominantly a little, with very rare determinerless or modified instances, such as very little. Little modifies a wide range of “targets,” but most frequently adjectives and prepositional phrases, focusing on human states and circumstantial detail. With regard to variation and change, adverbial little declines in use over the 200 years and is used more commonly by speakers from the lower social ranks and by the lay, non-professional participants in the courtroom.

scholarly journals Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

2011 ◽  
Vol 7 (2) ◽  
pp. e1001273 ◽  
Author(s):  
Guido Ferrari ◽  
Bette Korber ◽  
Nilu Goonetilleke ◽  
Michael K. P. Liu ◽  
Emma L. Turnbull ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Functional Profile ◽  
Escape Mutants ◽  
Acute Hiv ◽  
Hiv 1 ◽  
Selection Of

scholarly journals Distinct Subcellular Localization Patterns Contribute to Functional Specificity of the Cln2 and Cln3 Cyclins of Saccharomyces cerevisiae

2000 ◽  
Vol 20 (2) ◽  
pp. 542-555 ◽  
Author(s):  
Mary E. Miller ◽  
Frederick R. Cross
Keyword(s):  
Cell Cycle ◽  
Subcellular Localization ◽  
Nuclear Localization ◽  
Nuclear Export ◽  
Cytoplasmic Localization ◽  
Cyclin Dependent Kinase ◽  
Functional Profile ◽  
Functional Specificity ◽  
Biochemical Fractionation ◽  
Nuclear Events

ABSTRACT The G1 cyclins of budding yeast drive cell cycle initiation by different mechanisms, but the molecular basis of their specificity is unknown. Here we test the hypothesis that the functional specificity of G1 cyclins is due to differential subcellular localization. As shown by indirect immunofluorescence and biochemical fractionation, Cln3p localization appears to be primarily nuclear, with the most obvious accumulation of Cln3p to the nuclei of large budded cells. In contrast, Cln2p localizes to the cytoplasm. We were able to shift localization patterns of truncated Cln3p by the addition of nuclear localization and nuclear export signals, and we found that nuclear localization drives a Cln3p-like functional profile, while cytoplasmic localization leads to a partial shift to a Cln2p-like functional profile. Therefore, forcing Cln3p into a Cln2p-like cytoplasmic localization pattern partially alters the functional specificity of Cln3p toward that of Cln2p. These results suggest that there are CLN-dependent cytoplasmic and nuclear events important for cell cycle initiation. This is the first indication of a cytoplasmic function for a cyclin-dependent kinase. The data presented here support the idea that cyclin function is regulated at the level of subcellular localization and that subcellular localization contributes to the functional specificity of Cln2p and Cln3p.

scholarly journals Dermatoglifía y su relación con el perfil morfo-funcional en un club de fútbol sala masculino profesional de Bogotá

2021 ◽  
Vol 10 (2) ◽  
pp. 76-90
Author(s):  
Angela Yazmín Gálvez Pardo ◽  
Anderson David Cortés García ◽  
Daniel Fabricio González Reina ◽  
Laura Elizabeth Castro Jiménez ◽  
Yenny Paola Argüello Gutierrez ◽  
...  
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
Functional Profile ◽  
Squat Jump ◽  
Jump Test ◽  
Explosive Force ◽  
Physical Abilities ◽  
Physical Capacities ◽  
The City ◽  
Sports Selection

Una óptima selección deportiva está formada por la valoración del genotipo (dermatoglifía) y el fenotipo (somatotipo, composición corporal y capacidades físicas). El propósito del estudio fue determinar la relación entre la dermatoglifía y el perfil morfo-funcional en deportistas profesionales de futbol sala en la ciudad de Bogotá. La muestra estuvo conformada por 12 hombres, quienes fueron evaluados antropométricamente, con porcentaje graso de 18,4 ± 5,9; masa músculo-esquelética de 32,4 ± 4,4 kg y un somatotipo endo-mesomórfico. Por medio de la dermatoglifía se determinó predominancia en los diseños dactilares presilla (69,2±23,1), D10 (11,3±3,6), SQTL (140,7±95,1). Por último, se valoró la fuerza explosiva con la prueba de Squat Jump, en la cual la posición de poste logró mayor altura. En conclusión, existe una predisposición hacia las capacidades físicas de velocidad, potencia, coordinación y resistencia, además la fuerza explosiva es mayor en deportistas con menor valor en el componente endomórfico y en el porcentaje de masa grasa. An optimal sports selection is formed by assessment of genotype (dermatoglyph) and phenotype (somatotype, body composition and physical abilities). The purpose of the study was to determine relationship between dermatoglyphics and morpho-functional profile in professional futsal athletes in the city Bogotá. The sample consisted of 12 men, who were anthropometrically evaluated, with a fat % of 18,4 ± 5,9; a musculoskeletal mass of 32,4 ± 4,4 kg and endo-mesomorphic somatotype. Through of dermatoglyphics, predominance was determined in the fingerprint designs L (69,2 ± 23,1), D10 (11,3 ± 3,6), SQTL (140,7 ± 95,1). Finally, explosive force was assessed with the Squat Jump test, in which the post position achieved the greatest height. In conclusion, there is a predisposition towards the physical capacities of speed, power, coordination and resistance, in addition the explosive force is greater in athletes with a lower value in endomorphic component and in percentage of fat mass.

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