Challenges in educating women about human papillomavirus (HPV) and HPV screening test results: Experience from an HPV demonstration project in North-Eastern Thailand

Background: Malaysia continues to have a high incidence of cervical cancer with a relatively high mortality rate due to late presentation. Pilot Project R.O.S.E was a cross-sectional study to assess acceptability, feasibility and reach of a cervical screening strategy that utilizes self-collected, point-of-care HPV testing in primary care settings. Within this study, mobile SMS technology was used to register patients into a cervical screening registry and to deliver the HPV test results. Aim: To assess the feasibility, acceptability, advantages and limitations of the use of mobile SMS technology to deliver HPV screening test results. Methods: Invitation for cervical screening was offered to women aged 30 to 65 years who are presenting to these clinics for care, or accompanying another individual. Upon agreeing to do the test, the nurse registered the woman's details and mobile number. A mobile phone verification SMS is triggered at this point. HPV results were delivered to women via mobile SMS within 3 working days. Phone-based surveys were conducted on randomly selected screened positives and screened negative women to ascertain acceptability of the screening and the usage of mobile technology. Results: Ninety percent of participants received their SMS results without any hitches. Ten percent of participants experienced problems with receiving their results SMS. Further investigations revealed that there were various reasons for message delivery failure. Posttest surveys revealed that majority of participants were satisfied with the use of mobile technology to receive HPV screening test results. Conclusion: This study suggests that the use of mobile SMS technology for delivery of HPV screening test results is feasible and acceptable. However, measures should be taken to overcome technology related failures. The findings of this implementation research may help to inform the design of future mobile SMS technology usage within health settings in Malaysia.

Download Full-text

Prevalence of positive screening test results and agreement between cytology and human papillomavirus testing in primary cervical cancer screening in North-Western Romania

European Journal of Cancer Prevention ◽

10.1097/cej.0000000000000522 ◽

2020 ◽

Vol 29 (2) ◽

pp. 141-148

Author(s):

Ofelia Şuteu ◽

Mihaiela L. Blaga ◽

Mari Nygård ◽

Maarit K. Leinonen ◽

Florian Nicula ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Screening Test ◽

Test Results ◽

Human Papillomavirus Testing ◽

North Western ◽

Western Romania ◽

Primary Cervical Cancer Screening

Download Full-text

Follow-up Outcomes in a Large Cohort of Patients With Human Papillomavirus–Negative ASC-H Cervical Screening Test Results

Yearbook of Pathology and Laboratory Medicine ◽

10.1016/j.ypat.2012.11.005 ◽

2013 ◽

Vol 2013 ◽

pp. 276-277

Author(s):

S.S. Raab

Keyword(s):

Human Papillomavirus ◽

Screening Test ◽

Cervical Screening ◽

Large Cohort ◽

Test Results

Download Full-text

The performance of the NanoCHIP® HPV screening panel, a novel molecular-based screening test utilizing microarray technology for simultaneous detection of high and low risk human papillomavirus (HPV) infections, in a regional clinical laboratory

10.26226/morressier.56d5ba2ad462b80296c964f9 ◽

2016 ◽

Author(s):

Zvi Greenberg

Keyword(s):

Human Papillomavirus ◽

Screening Test ◽

Clinical Laboratory ◽

Simultaneous Detection ◽

Low Risk ◽

Microarray Technology ◽

Hpv Screening

Download Full-text

Cytology and Human Papillomavirus Screening Test Results Associated With 2827 Histopathologic Diagnoses of Cervical Intraepithelial Neoplasia 2/3

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2012-0307-oa ◽

2012 ◽

Vol 137 (7) ◽

pp. 942-947 ◽

Cited By ~ 6

Author(s):

Chengquan Zhao ◽

Milon Amin ◽

Baoying Weng ◽

Xiangbai Chen ◽

Amal Kanbour-Shakir ◽

...

Keyword(s):

Human Papillomavirus ◽

Cervical Intraepithelial Neoplasia ◽

Screening Test ◽

Cervical Screening ◽

Intraepithelial Neoplasia ◽

High Grade ◽

Test Results ◽

Squamous Intraepithelial Lesion ◽

Squamous Cells ◽

Intraepithelial Lesion

Context.—Cervical screening in the United States increasingly involves newer US Food and Drug Administration–approved cytologic methods and adjunctive high-risk human papillomavirus (hrHPV) DNA testing. Objective.—To document cervical screening test performance preceding histopathologic cervical intraepithelial neoplasia (CIN) 2/3 diagnoses. Design.—Preceding screening test results with computer-imaged, liquid-based cytology (LBC) and hrHPV results were analyzed for 2827 patients with histopathologic CIN 2/3 diagnoses. Results.—Of 2827 patients with CIN 2/3 diagnoses, 2074 (73.4%) had system LBC findings within 4 months of CIN 2/3 diagnoses: high-grade squamous intraepithelial lesion (n = 862; 41.6%), low-grade squamous intraepithelial lesion (n = 464; 22.4%), atypical squamous cells of undetermined significance (n = 445; 21.5%), atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (n = 288; 13.9%), and atypical glandular cells/adenocarcinoma in situ (n = 15; 0.7%). Of the 2827 patients, 1488 (52.6%) also had earlier system LBC results at more than 4 months to 3 years before CIN 2/3 diagnoses: one or more abnormal LBC results (n = 978; 65.7%), one or more negative LBC results (n = 911; 61.2%), both abnormal and negative LBC (n = 401; 26.9%). Of 807 patients with hrHPV cotest results within 4 months of CIN 2/3 diagnoses, 786 (97.4%) had hrHPV+ results. Of 454 patients who also had earlier hrHPV results at more than 4 months to 3 years before CIN 2/3 diagnoses: 377 (83.0%) had one or more hrHPV+ result, 110 (24.2%) had one or more hrHPV− result, and 33 (7.3%) had both positive and negative HPV results. Conclusion.—Patients with histopathologic CIN 2/3 had recent abnormal LBC results, most often, high-grade squamous intraepithelial lesions. Among cotested patients, 97.4% (786 of 807) tested hrHPV+. However, a significant number of patients tested during an extended period of several years had earlier negative Papanicolaou or negative HPV test results, suggesting the recent development of some CIN 2/3 lesions and supporting the value of cotesting for enhanced detection of other developing, small, inaccessible, or nondiagnostic precursor lesions.

Download Full-text

Human Papillomavirus (HPV) 16 and 18/45 Genotyping-Directed Follow-up of Women With Messenger RNA HPV-Positive, Cytology-Negative Cervical Screening Test Results

American Journal of Clinical Pathology ◽

10.1093/ajcp/aqz156 ◽

2019 ◽

Vol 153 (2) ◽

pp. 243-250 ◽

Cited By ~ 2

Author(s):

Min Han ◽

Juan Li ◽

Marshall Austin ◽

Kavita R Varma ◽

Huina Zhang ◽

...

Keyword(s):

Human Papillomavirus ◽

Screening Test ◽

Messenger Rna ◽

Cervical Screening ◽

Test Results ◽

Positive Cytology ◽

Hpv 16 ◽

Cervical Adenocarcinomas ◽

High Risk Hpv

Abstract Objectives In this study, we sought to correlate genotype test results for human papillomavirus (HPV) types 16, 18, and 45 with histopathologic follow-up diagnoses in patients with messenger RNA (mRNA) high-risk HPV-positive, cytology-negative results. Methods We identified 1,157 patients with mRNA HPV-positive, cytology-negative cervical screening test results between June 2015 and June 2018. Reflex HPV 16/18/45 genotype results were documented in 1,018 women aged 30 years or older, 318 of whom had follow-up within 18 months. Results Histopathologic findings of cervical intraepithelial neoplasia 2 or worse (CIN2+) were diagnosed in 14 of 122 (11.5%) patients positive for HPV 16/18/45 vs in seven of 196 (3.6%) HPV 16/18/45–negative patients. Three patients with high-risk HPV–positive, cytology-negative cervical screening test results were diagnosed with stage I cervical adenocarcinomas following early colposcopic referral and biopsy after HPV 16/18/45–positive genotype results. Conclusions Immediate reflex HPV 16/18/45 genotyping of mRNA HPV-positive, cytology-negative patients led to early colposcopic referral and histopathologic diagnoses of three difficult-to-detect, low-stage, cervical adenocarcinomas and significantly increased overall early detection of CIN2+ lesions.

Download Full-text