Development of (acrylic acid/ polyethylene glycol)-zinc oxide mucoadhesive nanocomposites for buccal administration of propranolol HCl

2018 ◽  
Vol 147 ◽  
pp. 18-26 ◽  
Author(s):  
Ghada A. Mahmoud ◽  
Amr El-Hag Ali ◽  
Amany I. Raafat ◽  
Nagwa A. Badawy ◽  
Mai. F. Elshahawy
Keyword(s):  
Zinc Oxide ◽  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Propranolol Hcl

In vitro evaluation of mucoadhesive and self-disinfection efficiency of (acrylic acid/polyethylene glycol)-silver nanocomposites for buccal drug delivery

2017 ◽  
Vol 33 (1) ◽  
pp. 95-115 ◽  
Author(s):  
Amany I Raafat ◽  
Ghada A Mahmoud ◽  
Amr El-Hag Ali ◽  
Nagwa A Badawy ◽  
Mai F Elshahawy
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Drug Carrier ◽  
Copolymer Composition ◽  
Bacterial Strains ◽  
Γ Irradiation ◽  
X Ray ◽  
Propranolol Hcl ◽  
Buccal Drug Delivery

A mucoadhesive drug delivery system can improve the effectiveness of a drug, allowing targeting and localization at a specific site. According to this assumption, γ-irradiation as eco-friendly technique was employed to synthesize (acrylic acid/polyethylene glycol) copolymer hydrogel of different compositions. Silver nanoparticles were prepared within (acrylic acid/polyethylene glycol) hydrogel network by means of in situ reduction of silver nitrate using sodium borohydride as a reducing agent. Swelling characteristics in distilled water and simulated saliva solution were studied as a function of copolymer composition and preparation irradiation dose. (Acrylic acid/polyethylene glycol) hydrogels and their developed Agº nanocomposites have been characterized using scanning electron microscope, thermogravimetric analysis, transmission electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. Mucoadhesive strength as well as self-disinfection efficiency expressed as antibacterial activity against different bacterial strains was evaluated. Propranolol HCl as model drug was used to evaluate the potential efficiency of the obtained (acrylic acid/polyethylene glycol)-Agº nanocomposites as mucoadhesive drug carrier. The obtained results showed that the (acrylic acid/polyethylene glycol)-Agº nanocomposites show a promising self-disinfection property, and the propranolol HCl–loaded composites were able to deliver the loaded drug in a sustainable manner that lasts for about 600 min.

Optical Characteristics of Zinc Oxide Nanoparticles with Surface Modification Using Polyethylene Glycol

2014 ◽  
Vol 29 (10) ◽  
pp. 1039
Author(s):  
TAN Man-Lin ◽  
WANG Yan-Tao ◽  
ZHANG Wei-Li ◽  
FU Dong-Ju ◽  
LI Dong-Shuang ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Surface Modification ◽  
Polyethylene Glycol ◽  
Zinc Oxide Nanoparticles ◽  
Optical Characteristics ◽  
Oxide Nanoparticles

scholarly journals The use of differential calculation methods for the destruction of copolymers of polyethylene glycol fumarate with the acrylic acid

2020 ◽  
Vol 99 (3) ◽  
pp. 4-10
Author(s):  
M.Zh. Burkeev ◽  
◽  
A.Zh. Sarsenbekova ◽  
A.N. Bolatbay ◽  
E.M. Tazhbaev ◽  
...  
Keyword(s):  
Activation Energy ◽  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Polyester Resin ◽  
Thermodynamic Characteristics ◽  
Nitrogen Atmosphere ◽  
Inert Medium ◽  
Good Convergence ◽  
Sample Decomposition ◽  
First Time

In this work, the thermal decomposition of copolymers based on polyethylene glycol fumarate with the acrylic acid using various ratios of initial monomers has been studied for the first time. The samples were studied in air and nitrogen. According to the thermograms analysis, it was found that the copolymer sample decomposition begins at higher temperatures for a copolymer with high content of polyester resin. The copolymer is vigorously oxidized by the oxygen when heated in air, and one can observe almost complete sample decomposition, whereas it decomposes with a residue of ~ 15% in an inert medium. The activation energies for copolymers with different compositions were estimated using the differential methods of Freeman-Carroll, Achar and Sharpe-Wentworth. The activation energy values found by the three methods demonstrated a good convergence. It was shown that, the activation energy values are higher (~ 200 kJ/mol in the inert medium, and ~ 95 kJ/mol in the oxygen atmosphere) for a copolymer with a lower composition of polyester resin, and the activation energy is ~180 and ~85 kJ/mol for a copolymer with a greater composition of p-EGF-AA. The copolymer is more thermostable in the nitrogen atmosphere according to the kinetic parameters. Additionally, there were determined the thermodynamic characteristics, such as the Gibbs energy (∆G) and the entropy (∆S). They also confirm the destruction process dependence on the components ratio in the synthesized copolymer.

In Vitro Response of Osteoblast-Like Cells to Hydroxyapatite-Zinc Oxide-Poly(Acrylic Acid) Cements

2001 ◽  
Vol 218-220 ◽  
pp. 347-352 ◽  
Author(s):  
S. Kenny ◽  
Martin Buggy ◽  
T. Pembroke ◽  
R. Hill ◽  
P.V. Hatton
Keyword(s):  
Zinc Oxide ◽  
Acrylic Acid ◽  
In Vitro Response ◽  
Poly Acrylic Acid

Polyacryloyl hydrazide based injectable & stimuli responsive hydrogels with tunable properties

2014 ◽  
Vol 2 (42) ◽  
pp. 7429-7439 ◽  
Author(s):  
Anuj Kumar ◽  
Sabindra K. Samal ◽  
Rupesh Dash ◽  
Umaprasana Ojha
Keyword(s):  
Polyethylene Glycol ◽  
Acrylic Acid ◽  
Diethyl Malonate ◽  
Synthesis And Characterization ◽  
Cross Linking ◽  
Stimuli Responsive ◽  
Polyethylene Glycol Diacrylate ◽  
Glycol Diacrylate ◽  
Responsive Hydrogels

The synthesis and characterization of a series of injectable and stimuli responsive hydrogels based on polyacryloyl hydrazide have been accomplished using dimethyl 2,2′-thiodiacetate, acrylic acid, diethyl malonate and polyethylene glycol diacrylate as cross-linkers through a chemical or dual cross-linking pathway.

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