scholarly journals Respiratory morbidities and lung function abnormalities in survivors of Bhopal Gas Disaster: A cross-sectional study

2021 ◽  
Author(s):  
Sajal De ◽  
Nalok Banerjee ◽  
Yogesh Sabde
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gas Disaster

scholarly journals Respiratory Morbidities and Lung Function Abnormalities in Survivors of Bhopal Gas Disaster: A Cross-Sectional Study

2021 ◽  
Author(s):  
Sajal De ◽  
Nalok Banerjee ◽  
Yogesh Sabde
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Small Airway ◽  
Respiratory Morbidity ◽  
Forced Oscillation Technique ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gas Disaster ◽  
The Mean ◽  
Lower Limit Of Normal

Abstract Background Respiratory morbidities remained major morbidities among the survivors of the Bhopal gas disaster. We hypothesized that underlying lung function abnormalities, especially small airway dysfunctions (SAD), were responsible for persistent respiratory morbidity. Material and methods We conducted a cross-sectional study between 2018 and 2020 in the severely exposed cohort of the Bhopal gas disaster. A standardized questionnaire was used to collect respiratory symptoms. The forced oscillation technique (FOT) and spirometry were used for assessing lung functions. Univariate and multivariate logistic regression analyses were used to examine the association. Results Total 916 individuals (men: 442) participated. The mean age was 55.2 ± 12.3 years. Breathlessness was a predominant respiratory complaint (71.7%), followed by cough (15.1%). Five hundred fifty-eight individuals participated in lung function assessment. The R5 > ULN (upper limit of normal), R5 − 19 >ULN, and X5 < LLN (lower limit of normal) were observed in 29.3%, 23.3%, and 21.2% participants, respectively. Normal, obstructive, and restrictive spirometry was observed in 46.2%, 26.1%, and 27.7% of participants, respectively. Abnormalities in FOT parameters were observed in 25.3% of individuals with normal spirometry. Individuals with obstructive spirometry had the highest risk of abnormal FOT parameters (adj OR:3.93, 95% CI: 2.24–6.89). Breathlessness showed a significant association with abnormal R5 (adj OR: 1.81; 95% CI: 1.13–2.91) and obstructive spirometry (adj OR: 2.26; 95% CI: 1.29–3.95). Conclusion Assessment of small airway functions, in addition to spirometry, will help to identify complex lung function abnormalities in the population exposed to toxic inhalation.

scholarly journals Recurrent wheeze and its relationship with lung function and airway inflammation in preschool children: a cross-sectional study in South Korea

BMJ Open ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. e018010 ◽  
Author(s):  
Ji Eun Soh ◽  
Kyung-Moon Kim ◽  
Ji-Won Kwon ◽  
Hyung Young Kim ◽  
Ju-Hee Seo ◽  
...  
Keyword(s):  
Preschool Children ◽  
Lung Function ◽  
Airway Inflammation ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Airway Function ◽  
Recurrent Wheeze

BackgroundRelationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known.ObjectiveTo investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children.DesignObservational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%–75%), dose–response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without.SettingPopulation-based, cross-sectional study in Seoul and the Gyeonggi province of Korea conducted as a government-funded programme to perform standardised measurement of the prevalence of allergic diseases, and related factors, in preschool children.Participants900 children aged 4–6 years.Primary and secondary outcome measureseNO, FEV1/FVC, FEF25%–75%, DRS, atopic sensitisation and allergic diseases.MethodsChildren completed the modified International Study of Asthma and Allergies in Childhood questionnaire and underwent eNO assessments, spirometry, methacholine bronchial provocation tests and skin prick tests. Recurrent wheeze was defined as having a lifetime wheeze of more than three episodes, based on the questionnaire. The frequency of hospitalisation and emergency room visits was also obtained by means of the questionnaire. ‘Current’ wheeze was defined as having symptoms or treatments within the past 12 months.ResultsThe prevalence of recurrent wheeze was 13.4%. Children with recurrent wheeze showed a higher prevalence of lifetime or current allergic rhinitis (p=0.01 and p=0.002, respectively) and lifetime atopic dermatitis (p=0.007). Children with recurrent wheeze showed lower FEV1/FVC (p=0.033) and FEF25%–75%(p=0.004), and higher eNO levels (p=0.013) than those without recurrent wheeze. However, the DRS, prevalence of atopic sensitisation and serum IgE levels were not significantly different between the two groups.ConclusionsRecurrent wheeze in preschool children may be associated with airway inflammation and diminished airway function, but not with AHR or atopy.

scholarly journals Relationship between depression and lung function in the general population in Korea: a retrospective cross-sectional study

2018 ◽  
Vol Volume 13 ◽  
pp. 2207-2213 ◽  
Author(s):  
Youngmok Park ◽  
Ji Ye Jung ◽  
Young Sam Kim ◽  
Kyung Soo Chung ◽  
Joo Han Song ◽  
...  
Keyword(s):  
Lung Function ◽  
General Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Health consequences of thick forest fire smoke to healthy residents in Riau, Indonesia: a cross-sectional study

2020 ◽  
Vol 29 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Jamal Zaini ◽  
Agus Dwi Susanto ◽  
Erlang Samoedro ◽  
Vonni Christiana Bionika ◽  
Budhi Antariksa
Keyword(s):  
Lung Function ◽  
Forest Fire ◽  
Respiratory Symptoms ◽  
Cross Sectional Study ◽  
Healthy Individuals ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fire Disaster ◽  
Fire Smoke ◽  
Forest Fire Disaster

BACKGROUND Indonesia forest fire in 2015 emitted a huge amount of pollutants into the air. This study was aimed to assess the health consequences of forest fire smoke in healthy residents in Riau during forest fire disaster in 2015. METHODS This cross-sectional study was performed in healthy residents who lived in Pekanbaru, Riau Province, Sumatera, for at least 6 months during forest fire disaster in 2015, and data were taken in October 2015. Questionnaires consisting of respiratory and non-respiratory symptoms were collected. Lung function was assessed by spirometry (MIR II Spirolab™ spirometer, Medical International Research, Italy) and exhaled carbon monoxide (CO) was assessed using piCO+ Smokerlyzer®. Heart rate at rest and oxygen saturation in the room air were measured using Onyx 9591 Pulse Oximeter®. RESULTS A total of 89 subjects were mostly female (75.3%), housewife (37.7%), nonsmoker (86.5%) with mean age of 38.9 years old. The non-respiratory and respiratory symptoms were reported in 84.7% and 71.4% subjects, respectively. Lung function was impaired in 72.6% subjects, mostly with mild obstruction and mild restriction. Exhaled CO was highly detected over normal values (mean [standard deviation] = 32.6 [9.97] ppm) with predicted carboxyhemoglobin (COHb) of 5.74 (1.56). CONCLUSIONS Forest fire smoke exposure increased the respiratory and nonrespiratory symptoms among healthy individuals, which showed impairment in lung function, exhaled CO, and predicted COHb. Long term health effects on healthy individuals exposed to forest fire smoke warrant further evaluation.

Effect of lung function on the apnea-hypopnea index in patients with overlap syndrome: a multicenter cross-sectional study

2019 ◽  
Vol 24 (3) ◽  
pp. 1059-1066 ◽  
Author(s):  
Jing Zhu ◽  
Zhiling Zhao ◽  
Qingrong Nie ◽  
Yingnan Wang ◽  
Zhen Fu ◽  
...  
Keyword(s):  
Lung Function ◽  
Cross Sectional Study ◽  
Overlap Syndrome ◽  
Apnea Hypopnea Index ◽  
Sectional Study ◽  
Cross Sectional
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