Vascular and cardiac autonomic function and PM2.5 constituents among the elderly: A longitudinal study

AbstractThe impact of most, but not all, cardiovascular risk factors decline by age. We investigated how the metabolic syndrome (MetS) was related to cardiovascular disease (CVD) during 40 years follow-up in the Uppsala Longitudinal Study of Adult Men (ULSAM, 2,123 men all aged 50 at baseline with reinvestigations at age 60, 70, 77 and 82). The strength of MetS as a risk factor of incident combined end-point of three outcomes (CVD) declined with ageing, as well as for myocardial infarction, ischemic stroke and heart failure when analysed separately. For CVD, the risk ratio declined from 2.77 (95% CI 1.90–4.05) at age 50 to 1.30 (95% CI 1.05–1.60) at age 82. In conclusion, the strength of MetS as a risk factor of incident CVD declined with age. Since MetS was significantly related to incident CVD also at old age, our findings suggest that the occurrence of MetS in the elderly should not be regarded as innocent. However, since our data were derived in an observational study, any impact of MetS in the elderly needs to be verified in a randomized clinical intervention trial.

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Cardiac autonomic function evaluation in pediatric and adult patients with congenital myasthenic syndromes

Neuromuscular Disorders ◽

10.1016/j.nmd.2019.02.004 ◽

2019 ◽

Vol 29 (4) ◽

pp. 290-295

Author(s):

Ceren Günbey ◽

Kutay Sel ◽

Çağrı Mesut Temuçin ◽

Hayrettin Hakan Aykan ◽

Bahadır Konuşkan ◽

...

Keyword(s):

Autonomic Function ◽

Adult Patients ◽

Function Evaluation ◽

Cardiac Autonomic Function ◽

Congenital Myasthenic Syndromes ◽

Myasthenic Syndromes

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Early-life environment influencing susceptibility to cytomegalovirus infection: evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins

Epidemiology and Infection ◽

10.1017/s0950268811001397 ◽

2011 ◽

Vol 140 (5) ◽

pp. 835-841 ◽

Cited By ~ 9

Author(s):

L. H. MORTENSEN ◽

A. B. MAIER ◽

P. E. SLAGBOM ◽

G. PAWELEC ◽

E. DERHOVANESSIAN ◽

...

Keyword(s):

Longitudinal Study ◽

Human Cytomegalovirus ◽

Family Environment ◽

Early Life ◽

Cytomegalovirus Infection ◽

Genetic Factors ◽

The Elderly ◽

Same Sex ◽

Cmv Infection ◽

Early Life Environment

SUMMARYHuman cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73–94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had significantly lower seroprevalence of CMV compared to their partners (offspring: 42%vs. partners: 51%,P=0·003). Of 372 offspring living with a CMV-positive partner, only 58% were infected. The corresponding number for partners was 71% (P<0·001). In the LSADT, MZ and DZ twins had high and similar CMV-positive concordance rates (MZ: 90%vs. DZ: 88%,P=0·51) suggesting that shared family environment accounts for the similarity within twin pairs. Our findings suggest that susceptibility to CMV infection – even under continuous within-partnership exposure – appears to be more strongly influenced by early-life environment than by genetic factors and adult environment.

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