scholarly journals Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia

2018 ◽  
Vol 12 ◽  
pp. 11-19 ◽  
Author(s):  
Rose Mary Xavier ◽  
Jennifer R. Dungan ◽  
Richard S.E. Keefe ◽  
Allison Vorderstrasse
Keyword(s):  
Cognitive Performance ◽  
Chronic Schizophrenia ◽  
Symptom Dimensions

AUTOBIOGRAPHICAL MEMORY DEFICITS AND THEIR RELATIONSHIP WITH SYMPTOM DIMENSIONS IN OLDER PATIENTS WITH CHRONIC SCHIZOPHRENIA

2010 ◽  
Vol 117 (2-3) ◽  
pp. 216
Author(s):  
Lena A. Schmid ◽  
Marc M. Lässer ◽  
Christina J. Herold ◽  
Ulrich Seidl ◽  
Johannes Schröder
Keyword(s):  
Autobiographical Memory ◽  
Older Patients ◽  
Chronic Schizophrenia ◽  
Memory Deficits ◽  
Symptom Dimensions

Cognitive complaints in schizophrenia are associated with clinical symptoms and global functioning but not actual cognitive performance

2011 ◽  
Vol 26 (S2) ◽  
pp. 1421-1421
Author(s):  
D. Kontis ◽  
E. Theochari ◽  
S. Kleisas ◽  
I. Makris ◽  
S. Kalogerakou ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Clinical Symptoms ◽  
Cognitive Impairments ◽  
Neuropsychological Testing ◽  
Depression Scale ◽  
Chronic Schizophrenia ◽  
Cognitive Complaints ◽  
Global Functioning ◽  
Subjective Scale ◽  
Positive Correlations

IntroductionAlthough it is well established that patients with schizophrenia demonstrate cognitive impairments, little is known about their complaints concerning their cognition. We investigate the association of these complaints with clinical symptoms, global functioning and cognitive performance.Method93 patients with chronic schizophrenia (mean age = 42,59 years, SD = 9,83; mean illness duration = 18,43 years, SD = 11,84) were recruited from one psychiatric department. Their cognitive complaints (Subjective Scale to Investigate Cognition in Schizophrenia-SSTICS), clinical symptoms (Calgary depression scale-CDS, PANSS, GAF), and neuropsychological performance (7 non-verbal CANTAB tests involving psychomotor speed, attention, memory, and executive function and WAIS-III) were assessed at a time that they were able to cooperate with neuropsychological testing. Correlation analyses were performed between SSTICS scores and measures of symptoms, functioning or cognition, using the SPSS.ResultsSSTICS total score positively correlated with CDS total score (Spearman's rho = 0.311, p = 0.03). Positive correlations were also found between the SSTICS items and CDS total score. Similarly, SSTICS total score positively correlated with PANSS total score (Pearson r = 0,294, p = 0.04). PANSS negative and general psychopathology scores (r = 0,219, p = 0.035 and r = 0.333, p = 0.01, respectively), but not PANSS positive scores accounted for this relationship. SSTICS total score negatively correlated with GAF (rho = −0.251, p = 0.017). No significant associations were revealed between SSTICS total scores and PANSS insight item, PANSS cognitive score, CANTAB or WAIS scores.ConclusionsThe complaints of patients with schizophrenia about their cognitive impairments are mostly related to their depressive, negative, general psychopathological symptoms and global functioning, rather than their actual cognitive deficits.

scholarly journals Global functioning among middle-aged patients with chronic schizophrenia: the role of medication, working memory and verbal comprehension

2019 ◽  
Vol 35 (2) ◽  
pp. 204-213 ◽  
Author(s):  
Maria Ruiz-Iriondo ◽  
Karmele Salaberria ◽  
Enrique Echeburua ◽  
Alvaro Iruin ◽  
Olga Gabaldón Poc ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Cognitive Performance ◽  
Verbal Learning ◽  
Chronic Phase ◽  
Chronic Schizophrenia ◽  
Middle Aged ◽  
Global Functioning ◽  
Aged Patients

The chronic phase of schizophrenia is characterized by illness progression and patients encountering difficulties to return to premorbid level of functioning. The objective of this study was to describe the characteristics of a sample of patients with chronic schizophrenia, as well to assess differences between patients under and over 45 years of age. In a clinical sample of 77 chronic schizophrenia patients, we assessed basic symptoms, cognitive performance, social functioning and quality of life. All participants obtained very high scores in residual symptoms, and no differences in sociodemographic or clinical characteristics between the age groups were found. Younger patients had better cognitive performance and older patients obtained better scores for social functioning and quality of life. Number of psychotropic drugs, verbal learning delayed of SCIP, errors in WCST, Similarities and Digit Symbol Coding of WAIS were the most important variables to predict global functioning of patients over 45 years old. Increasing our understanding of differences in characteristics of the chronic phase of the illness and the profile of functioning at different ages, may help us design intervention strategies to improve adaptation in young and middle-aged patients with chronic schizophrenia.

scholarly journals Modafinil modulates anterior cingulate function in chronic schizophrenia

2005 ◽  
Vol 187 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Sean A. Spence ◽  
Russell D. Green ◽  
Iain D. Wilkinson ◽  
Mike D. Hunter
Keyword(s):  
Working Memory ◽  
Anterior Cingulate Cortex ◽  
Cognitive Performance ◽  
Cognitive Deficits ◽  
Brain Activity ◽  
Memory Task ◽  
Cingulate Cortex ◽  
Chronic Schizophrenia ◽  
Anterior Cingulate ◽  
Double Blind

BackgroundSchizophrenia is associated with widespread cognitive deficits that have an impact on social function. Modafinil promotes wakefulness and is reported to enhance cognition.AimsTo study the acute effects of modafinil administration upon brain activity and cognitive performance in people with chronic schizophrenia.MethodIn a randomised double-blind placebo-controlled crossover design, 19 patients received either modafinil (100 mg) or placebo prior to undertaking a working memory task with functional magnetic resonance imaging.ResultsSeventeen patients completed the study and another underwent acute relapse 4 days post-drug. Modafinil administration was associated with significantly greater activation in the anterior cingulate cortex during the working memory task. The anterior cingulate cortex signal correlated with cognitive performance, although only a subset of patients exhibited ‘enhancement’.ConclusionsModafinil modulates anterior cingulate cortex function in chronic schizophrenia but its beneficial cognitive effects may be restricted to a subset of patients requiring further characterisation.

P.0592 Investigating the relationships of N100-P3b with symptom dimensions and cognitive impairments in subjects with chronic schizophrenia

2021 ◽  
Vol 53 ◽  
pp. S432-S433
Author(s):  
G.M. Giordano ◽  
A. Perrottelli ◽  
A. Mucci ◽  
G. Di Lorenzo ◽  
F. Ferrentino ◽  
...  
Keyword(s):  
Cognitive Impairments ◽  
Chronic Schizophrenia ◽  
Symptom Dimensions

Cognitive Performance in Patients with Chronic Schizophrenia Across the Lifespan

GeroPsych ◽  
2017 ◽  
Vol 30 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Christina Josefa Herold ◽  
Lena Anna Schmid ◽  
Marc Montgomery Lässer ◽  
Ulrich Seidl ◽  
Johannes Schröder
Keyword(s):  
Cognitive Performance ◽  
Cognitive Flexibility ◽  
Cognitive Deficits ◽  
Digit Span ◽  
Age Groups ◽  
Chronic Schizophrenia ◽  
Age Effects ◽  
Healthy Controls ◽  
Neuropsychological Functions ◽  
Older Subjects

Abstract. Chronic schizophrenia involves neuropsychological deficits that primarily strike executive functions and episodic memory. Our study investigated these deficits throughout the lifespan in patients with chronic schizophrenia and in healthy controls. Important neuropsychological functions were tested in 94 patients and 66 healthy controls, who were assigned to three age groups. Compared with the healthy controls, patients performed significantly poorer on all tests applied. Significant age effects occurred on all tests except the digit span forward, with older subjects scoring well below the younger ones. With respect to cognitive flexibility, age effects were more pronounced in the patients. These findings underline the importance of cognitive deficits in chronic schizophrenia and indicate that diminished cognitive flexibility shows age-associated differences.

scholarly journals T81. LONG-TERM COURSE OF COGNITIVE PERFORMANCE IN PATIENTS WITH CHRONIC SCHIZOPHRENIA

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S146-S146
Author(s):  
Thaís Martins ◽  
Thalita Fernandes ◽  
Diego Mendes ◽  
Gustavo Mustafé ◽  
Luis Fernando Pegoraro ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Chronic Schizophrenia

scholarly journals Characteristics of White Matter Structural Networks in Chronic Schizophrenia Treated With Clozapine or Risperidone and Those Never Treated

2020 ◽  
Vol 23 (12) ◽  
pp. 799-810 ◽  
Author(s):  
Chunyan Luo ◽  
Rebekka Lencer ◽  
Na Hu ◽  
Yuan Xiao ◽  
Wenjing Zhang ◽  
...  
Keyword(s):  
Cognitive Function ◽  
White Matter ◽  
Cognitive Performance ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
Chronic Schizophrenia ◽  
Global Network ◽  
Antipsychotic Treatment ◽  
Performance Levels ◽  
Structural Networks

Abstract Background Despite its benefits, a major concern regarding antipsychotic treatment is its possible impact on the brain’s structure and function. This study sought to explore the characteristics of white matter structural networks in chronic never-treated schizophrenia and those treated with clozapine or risperidone, and its potential association with cognitive function. Methods Diffusion tensor imaging was performed on a unique sample of 34 schizophrenia patients treated with antipsychotic monotherapy for over 5 years (17 treated with clozapine and 17 treated with risperidone), 17 never-treated schizophrenia patients with illness duration over 5 years, and 27 healthy control participants. Graph theory and network-based statistic approaches were employed. Results We observed a disrupted organization of white matter structural networks as well as decreased nodal and connectivity characteristics across the schizophrenia groups, mainly involving thalamus, prefrontal, and occipital regions. Alterations in nodal and connectivity characteristics were relatively milder in risperidone-treated patients than clozapine-treated patients and never-treated patients. Altered global network measures were significantly associated with cognitive performance levels. Structural connectivity as reflected by network-based statistic mediated the difference in cognitive performance levels between clozapine-treated and risperidone-treated patients. Limitations These results are constrained by the lack of random assignment to different types of antipsychotic treatment. Conclusion These findings provide insight into the white matter structural network deficits in patients with chronic schizophrenia, either being treated or untreated, and suggest white matter structural networks supporting cognitive function may benefit from antipsychotic treatment, especially in those treated with risperidone.

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