Cognitive complaints in schizophrenia are associated with clinical symptoms and global functioning but not actual cognitive performance

2011 ◽  
Vol 26 (S2) ◽  
pp. 1421-1421
Author(s):  
D. Kontis ◽  
E. Theochari ◽  
S. Kleisas ◽  
I. Makris ◽  
S. Kalogerakou ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Clinical Symptoms ◽  
Cognitive Impairments ◽  
Neuropsychological Testing ◽  
Depression Scale ◽  
Chronic Schizophrenia ◽  
Cognitive Complaints ◽  
Global Functioning ◽  
Subjective Scale ◽  
Positive Correlations

IntroductionAlthough it is well established that patients with schizophrenia demonstrate cognitive impairments, little is known about their complaints concerning their cognition. We investigate the association of these complaints with clinical symptoms, global functioning and cognitive performance.Method93 patients with chronic schizophrenia (mean age = 42,59 years, SD = 9,83; mean illness duration = 18,43 years, SD = 11,84) were recruited from one psychiatric department. Their cognitive complaints (Subjective Scale to Investigate Cognition in Schizophrenia-SSTICS), clinical symptoms (Calgary depression scale-CDS, PANSS, GAF), and neuropsychological performance (7 non-verbal CANTAB tests involving psychomotor speed, attention, memory, and executive function and WAIS-III) were assessed at a time that they were able to cooperate with neuropsychological testing. Correlation analyses were performed between SSTICS scores and measures of symptoms, functioning or cognition, using the SPSS.ResultsSSTICS total score positively correlated with CDS total score (Spearman's rho = 0.311, p = 0.03). Positive correlations were also found between the SSTICS items and CDS total score. Similarly, SSTICS total score positively correlated with PANSS total score (Pearson r = 0,294, p = 0.04). PANSS negative and general psychopathology scores (r = 0,219, p = 0.035 and r = 0.333, p = 0.01, respectively), but not PANSS positive scores accounted for this relationship. SSTICS total score negatively correlated with GAF (rho = −0.251, p = 0.017). No significant associations were revealed between SSTICS total scores and PANSS insight item, PANSS cognitive score, CANTAB or WAIS scores.ConclusionsThe complaints of patients with schizophrenia about their cognitive impairments are mostly related to their depressive, negative, general psychopathological symptoms and global functioning, rather than their actual cognitive deficits.

scholarly journals F74. CLINICAL SYMPTOMS AND NOT OBJECTIVE COGNITIVE PERFORMANCE DRIVE SUBJECTIVE COGNITIVE COMPLAINTS IN PATIENTS WITH SCHIZOPHRENIA

2018 ◽  
Vol 44 (suppl_1) ◽  
pp. S248-S248
Author(s):  
Jack Cotter ◽  
Kiri Granger ◽  
John Evenden ◽  
Jennifer Barnett ◽  
Michael Sand
Keyword(s):  
Cognitive Performance ◽  
Clinical Symptoms ◽  
Cognitive Complaints ◽  
Subjective Cognitive Complaints

scholarly journals Presence or absence of cognitive complaints in Parkinson’s disease: mood disorder or anosognosia?

2016 ◽  
Vol 74 (6) ◽  
pp. 439-444 ◽  
Author(s):  
Pollyanna Celso F. Castro ◽  
Camila Catherine Aquino ◽  
André C. Felício ◽  
Flávia Doná ◽  
Leonardo M. I. Medeiros ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Performance ◽  
Depression Scale ◽  
Cognitive Complaints ◽  
Boston Naming Test ◽  
Clock Drawing Test ◽  
Cognitive Complaint ◽  
Subjective Cognitive Complaint ◽  
And Control

ABSTRACT We intended to evaluate whether non-demented Parkinsons’s disease (PD) patients, with or without subjective cognitive complaint, demonstrate differences between them and in comparison to controls concerning cognitive performance and mood. We evaluated 77 subjects between 30 and 70 years, divided as follows: PD without cognitive complaints (n = 31), PD with cognitive complaints (n = 21) and controls (n = 25). We applied the following tests: SCOPA-Cog, Trail Making Test-B, Phonemic Fluency, Clock Drawing Test, Boston Naming Test, Neuropsychiatric Inventory, Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory. PD without complaints presented lower total score on Scales for outcome of Parkinson’s disease-cognition as compared to controls (p = 0.048). PD with complaints group showed higher scores on HADS (p = 0.011). PD without complaints group showed poorer cognitive performance compared to controls, but was similar to the PD with complaints group. Moreover, this group was different from the PD without complaints and control groups concerning mood.

Cognitive Dysfunctions in Chronic Schizophrenia Patients in Relationship with Clinical and Functional Capacity

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
C. Tintila ◽  
I.V. Miclutia ◽  
C. Popescu ◽  
I. Barsan
Keyword(s):  
Functional Capacity ◽  
Spatial Working Memory ◽  
Psychiatric Symptoms ◽  
Cognitive Impairments ◽  
Chronic Schizophrenia ◽  
Control Group ◽  
Central Feature ◽  
List Type ◽  
Global Functioning ◽  
Cognitive Dysfunctions

Aims:The aims of the current study are:•To examine the clinical symptoms and functional capacity of the patients.•To evaluate the cognitive dysfunctions and to see how they develop in 6 month.•To examine the relationship between clinical and functional capacity and the cognitive dysfunctions of the chronic schizophrenia patients.Method:24 people with chronic schizophrenia were followed up 6 month along with a control group of 50 individuals free from schizophrenia. Patients were diagnosed using DSM-IV criteria, assessed with the PANSS, GAF, to evaluate psychiatric symptoms, respectively functionality. Rey Memory Test, Trail Making, Spatial Recognition Memory (SRM),Spatial Working Memory (SWM), Paired Associated Learning (PAL), Spatial Spam (SSP) and Stoking of Cambridge (SOC) from the CANTAB were applied to all patients at the start point of the study and after 6 month, in order to evaluate the cognitive functions.Results:The overall performance of chronic schizophrenia patients was significantly lower compared to healthy individuals on all cognitive tasks. the cognitive dysfunction is independent of age and intellectual level, but does correlate with global functioning and remain stable. CANTAB is a useful tool to detect and estimate the cognitive impairments.Conclusions:The current study reveals that cognitive impairments are a central feature of schizophrenia and a major cause of poor functioning of the patients. the chronic schizophrenia patients perform worse on all investigated cognitive domains (memory, attention and executive function). the reviewed studies show different opinions about the development of these impairments. Further longitudinal studies are required in order to settle if they remain stable or progress in time.

scholarly journals Global functioning among middle-aged patients with chronic schizophrenia: the role of medication, working memory and verbal comprehension

2019 ◽  
Vol 35 (2) ◽  
pp. 204-213 ◽  
Author(s):  
Maria Ruiz-Iriondo ◽  
Karmele Salaberria ◽  
Enrique Echeburua ◽  
Alvaro Iruin ◽  
Olga Gabaldón Poc ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Cognitive Performance ◽  
Verbal Learning ◽  
Chronic Phase ◽  
Chronic Schizophrenia ◽  
Middle Aged ◽  
Global Functioning ◽  
Aged Patients

The chronic phase of schizophrenia is characterized by illness progression and patients encountering difficulties to return to premorbid level of functioning. The objective of this study was to describe the characteristics of a sample of patients with chronic schizophrenia, as well to assess differences between patients under and over 45 years of age. In a clinical sample of 77 chronic schizophrenia patients, we assessed basic symptoms, cognitive performance, social functioning and quality of life. All participants obtained very high scores in residual symptoms, and no differences in sociodemographic or clinical characteristics between the age groups were found. Younger patients had better cognitive performance and older patients obtained better scores for social functioning and quality of life. Number of psychotropic drugs, verbal learning delayed of SCIP, errors in WCST, Similarities and Digit Symbol Coding of WAIS were the most important variables to predict global functioning of patients over 45 years old. Increasing our understanding of differences in characteristics of the chronic phase of the illness and the profile of functioning at different ages, may help us design intervention strategies to improve adaptation in young and middle-aged patients with chronic schizophrenia.

scholarly journals Cross-Cultural Comparisons of Subjective Cognitive Complaints in a Diverse Primary Care Population

2021 ◽  
pp. 1-11
Author(s):  
Danelly Rodríguez ◽  
Emmeline Ayers ◽  
Erica F. Weiss ◽  
Joe Verghese
Keyword(s):  
Primary Care ◽  
Depressive Symptoms ◽  
Cognitive Function ◽  
African Americans ◽  
Primary Care Clinic ◽  
Depression Scale ◽  
Cognitive Complaints ◽  
Care Clinic ◽  
Primary Care Population ◽  
Subjective Cognitive Complaints

Background: Very few studies have explored the utility of subjective cognitive complaints (SCCs) in primary care settings. Objective: We aim to investigate associations between SCCs (item-level), objective cognitive function (across domains and global), and mood in a diverse primary care population, including subjects with mild cognitive impairment. Methods: We studied 199 (75.9%females; 57.8%Hispanics; 42.2%African Americans) older adults (mean age 72.5 years) with memory concerns at a primary care clinic. A five-item SCC questionnaire, and objective cognitive assessments, including the Montreal Cognitive Assessment (MoCA) and the Geriatric Depression Scale, were administered. Results: Logistic regression analyses showed associations between SCC score and depressive symptoms. A memory-specific (“memory worsening”) SCC predicted scores on the MoCA (p = 0.005) in Hispanics. Conclusion: SCCs are strongly linked to depressive symptoms in African Americans and Hispanics in a primary care setting; a specific type of SCC is related to global cognitive function in Hispanics.

scholarly journals Rifaximin Alleviates Endotoxemia with Decreased Serum Levels of Soluble CD163 and Mannose Receptor and Partial Modification of Gut Microbiota in Cirrhotic Patients

Antibiotics ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 145 ◽  
Author(s):  
Kosuke Kaji ◽  
Soichiro Saikawa ◽  
Hiroaki Takaya ◽  
Yukihisa Fujinaga ◽  
Masanori Furukawa ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Intestinal Permeability ◽  
Neuropsychological Testing ◽  
Mannose Receptor ◽  
Serum Levels ◽  
Ammonia Level ◽  
Decompensated Cirrhosis ◽  
Soluble Cd163 ◽  
Endotoxin Activity ◽  
Positive Correlations

Rifaximin is a poorly absorbable antibiotic against hepatic encephalopathy (HE). This observational study aimed to elucidate the effect of rifaximin on intestinal permeability and gut microbiota in patients with decompensated cirrhosis. Thirty patients with decompensated cirrhosis were assessed by ammonia level, neuropsychological testing, endotoxin activity (EA), and serum proinflammatory cytokines at baseline and after four weeks of rifaximin treatment (1200 mg/day). Intestinal permeability was indicated by serum soluble CD163 (sCD163), mannose receptor (sMR), and zonulin levels. To evaluate the gut microbiome, 16S ribosomal RNA gene sequencing was applied. Rifaximin ameliorated hyperammonemia and cognitive dysfunction, although it did not change the serum proinflammatory cytokine levels. It decreased EA levels as well as serum levels of sCD163 and sMR, but not zonulin, and both decreases in sCD163 and sMR showed positive correlations with EA decrease (ΔsCD163: Correlation coefficient (R) = 0.680, p = 0.023; ΔsMR: R = 0.613, p = 0.014, vs. ΔEA). Gut microbial analysis revealed that the richness and complexity of species were unchanged while the abundance of the Streptococcus genus was reduced after treatment with rifaximin. Collectively, rifaximin alleviated HE and endotoxemia with improved intestinal hyperpermeability in patients with decompensated cirrhosis, and this effect is partially involved in a gut microbial change.

scholarly journals Predictive Value of Subacute Heart Rate Variability for Determining Outcome Following Adolescent Concussion

2021 ◽  
Vol 10 (1) ◽  
pp. 161
Author(s):  
Colt A. Coffman ◽  
Jacob J. M. Kay ◽  
Kat M. Saba ◽  
Adam T. Harrison ◽  
Jeffrey P. Holloway ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cognitive Performance ◽  
Predictive Value ◽  
System Integration ◽  
Sports Medicine ◽  
Clinical Symptoms ◽  
Physiological Stress ◽  
Neurological Dysfunction ◽  
Neurobehavioral Function

Objective assessments of concussion recovery are crucial for facilitating effective clinical management. However, predictive tools for determining adolescent concussion outcomes are currently limited. Research suggests that heart rate variability (HRV) represents an indirect and objective marker of central and peripheral nervous system integration. Therefore, it may effectively identify underlying deficits and reliably predict the symptomology following concussion. Thus, the present study sought to evaluate the relationship between HRV and adolescent concussion outcomes. Furthermore, we sought to examine its predictive value for assessing outcomes. Fifty-five concussed adolescents (12–17 years old) recruited from a local sports medicine clinic were assessed during the initial subacute evaluation (within 15 days postinjury) and instructed to follow up for a post-acute evaluation. Self-reported clinical and depressive symptoms, neurobehavioral function, and cognitive performance were collected at each timepoint. Short-term HRV metrics via photoplethysmography were obtained under resting conditions and physiological stress. Regression analyses demonstrated significant associations between HRV metrics, clinical symptoms, neurobehavioral function, and cognitive performance at the subacute evaluation. Importantly, the analyses illustrated that subacute HRV metrics significantly predicted diminished post-acute neurobehavioral function and cognitive performance. These findings indicate that subacute HRV metrics may serve as a viable predictive biomarker for identifying underlying neurological dysfunction following concussion and predict late cognitive outcomes.

Biogenic amine-related enzymes and personality variations in normals

1977 ◽  
Vol 7 (1) ◽  
pp. 149-157 ◽  
Author(s):  
D. L. Murphy ◽  
R. H. Belmaker ◽  
M. Buchsbaum ◽  
N. F. Martin ◽  
R. Ciaranello ◽  
...  
Keyword(s):  
Biogenic Amine ◽  
Sensation Seeking ◽  
Amine Oxidase ◽  
Psychiatric Patients ◽  
Chronic Schizophrenia ◽  
Personality Variables ◽  
Scale Scores ◽  
Plasma Amine Oxidase ◽  
Positive Correlations ◽  
Sensation Seeking Scale

SynopsisAltered activities of biogenic amine-related enzymes have been reported in some studies of patients with affective disorders and chronic schizophrenia. To evaluate whether any relationship between personality variations, including non-diagnosed psychopathology, and these enzymes might occur in non-psychiatric patients, 95 young adult volunteers were studied. Higher MMPI and Zuckerman sensation-seeking scale scores were found in male, but not female, volunteers with lower platelet and plasma amine oxidase activities. Males generally exhibited negative correlations, while females had positive correlations between the psychological test scores and amine oxidase activities. In contrast to the amine oxidase results, no associations were observed between plasma dopamine β-hydroxylase activities and the personality variables.

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