scholarly journals Mechanisms of estrogen carcinogenesis: The role of E2/E1–quinone metabolites suggests new approaches to preventive intervention – A review

Steroids ◽  
2015 ◽  
Vol 99 ◽  
pp. 56-60 ◽  
Author(s):  
James D. Yager
Oikos ◽  
2014 ◽  
Vol 16 (33) ◽  
pp. 69
Author(s):  
Luis Muñoz Medina ◽  
Rafael Pizarro Rodríguez

The Role of Rhetoric and Metaphors in Organisational Change  RESUMEN El presente artículo es una recopilación de literatura científica que demuestra la relevancia de comprender nuevas formas de construir el concepto de cambio organizacional a través del lenguaje, en especial a través de claves lingüísticas como la retórica y metáfora. Esta construcción ayuda a generar procesos de cambio organizacional que presenten una menor intensidad y carga emocional negativa para los individuos, así como una mejor comprensión del mismo cambio para los empleados. Palabras clave: cambio, organización, retórica, metáfora. ABSTRACT This article is a compilation of scientific literature about the importance of understanding new approaches to the construction of the organisational change concept through language, especially through linguistic devices such as rhetorical and metaphorical ones. This construction helps the creation of organisational change processes with lower levels of impact and a lower negative emotional burden for individuals as well as a better understanding of such changesKeywords: changes; organisation; rhetoric; metaphor. 


PEDIATRICS ◽  
1967 ◽  
Vol 40 (5) ◽  
pp. 923-923
Author(s):  
JEROLD F. LUCEY ◽  
AUDREY K. BROWN ◽  
ALICE GAMBLE BEARD ◽  
MARVIN CORNBLATH ◽  
MOSES GROSSMAN ◽  
...  

THE physical design of and routine practices in neonatal units (especially nurseries for high-risk infants) are presently influenced almost entirely by considerations related to the risk of spreading infection in the nursery by fomites and personnel. The role of nursery design and specific routines in preventing epidemics is considered so important that the details are encoded in many local, state, and federal health laws or regulations. These are enforced by periodic inspections and conformity is made a prerequisite for official approval, allocation of funds, etc. Although there is little reason to doubt that these policies have had the effect of reducing the incidence of nursery epidemics, there is growing concern that official rigidity in these matters may interfere with optimal care of the very ill infant, as well as with research designed to improve care and find solutions to the overall problems of neonatal mortality and morbidity. Infections are an important and frequent cause of disease in the newborn. They are, however, clearly outdistanced by major non-infectious disorders that account for the majority of deaths and brain damage in the neonatal period (respiratory distress, asphyxia, acidosis, hypoglycemia, and hyperbilirubinemia). Some of the precautionary techniques used to reduce the risk of infections have the practical disadvantages of making it difficult (1) to approach the neonatal patient and (2) to apply modern diagnostic maneuvers and therapeutic aids in order to improve the neonatal patient's chances for intact survival. As a result the nursery-based infants in this country are, in general, quite well protected from the risks of nosocomial infections; but, they receive less than ideal management for cardiorespiratory disorders, a major cause of neonatal mortality. It is obvious that new solutions are required to solve the problem of hospital care of the sick neonate. Unfortunately, both the search for new approaches to neonatal care and the application of some newly established knowledge are now being impaired by rigid rules and construction codes which do not permit innovation. Although these rules cannot be completely abandoned until safe alternatives have been demonstrated, the Committee believes that public health administrators and hospital committees must permit cautious, responsible exploration and evaluation of new approaches to the multiple problems involved.


2021 ◽  
Author(s):  
Acatia Finbow

This chapter shows how over the past two decades the relationship between the museum and performance has undergone a radical shift with the acquisition of performance-based artworks into the collection, shifting the role of the museum from that of a repository to that of a vital participant in the activation of the work. This chapter reflects on the new value this turn affords to documentation, and on how it is being used to support the effective activation of performance-based artworks in the museum. It reflects particularly on Tate’s development of documentation practices that address these new institutional needs and on how these navigate both immediate and potential future value.


2020 ◽  
Vol 10 (2) ◽  
pp. 25-33
Author(s):  
Irina Smirnova

The issues raised in the article refer to the problems of Church diplomacy of Russia and other great powers in the Middle East in the 1850–1860’s when Russian diplomacy, both secular and church, faced the task of developing new approaches, first of all, in shaping the sphere of Russian interests in the Middle and Far East. Church policy of Russia in the Christian East in the 1850s–1860s is observed through the prism of the position of the Metropolitan of Moscow Filaret (Drozdov, 1782–1867), an outstanding church figure whose position determined the development of Russian church presence abroad not only in the Holy Land, but also in China and North America. The role of Metropolitan Filaret is presented in the forefront of such issues as the development of inter-church relations between the Russian Church with the Patriarchates of the East, the formation of the concept of Russian-Greek, Russian-Arab and Russian-Slavic relations, the interaction and contradictions of the Russian Ecclesiastical Mission and the Russian consulate in Jerusalem.


2017 ◽  
Vol 94 (11) ◽  
pp. 812-820
Author(s):  
Evgeniya S. Fedoseeva ◽  
M. V. Savostikova ◽  
M. N. Narimanov ◽  
A. A. Pashaev ◽  
S. S. Kirichenko ◽  
...  

This review is designed to discuss possibilities for the treatment of advanced gastric cancer with reference to the prognostic and predictive value of molecular-biological parameters and the influence of hereditary predisposition to the development of neoplastic process. The data on modern pharmacotherapy of this disease based on the knowledge of molecular-biological parameters are presented including the following markers: HER2/neu, VGFR, c-met, TUBB3, CDH-1, BRCA-1, EGFR, TGF-ß, p53, Ki67 and PCNA. It is emphasized that the role of molecular-biological parameters associated with advanced gastric cancer is ambiguous. The prognostic and predictive significance of some of the markers is confirmed while that of others remains to be elucidated and requires further research.


2020 ◽  
Vol 9 (29) ◽  
pp. 307-315
Author(s):  
Tatyana Aleksandrovna Sidorova ◽  
Elena Revovna Kornienko ◽  
Elvira Nikolaevna Akimova ◽  
Natalya Evgenyevna Petrova

The relevance of the research is due to the growing interest in finding new approaches to describing the discursive personality in General and professional, in particular. The main goal of the research is to identify the features of cognitive style and determine its role in the formation of professional discursive personality of N. I. Novikov as a journalist. The research is carried out within the framework of cognitive-discursive and linguistic paradigms. As the main one, we use an interpretative analysis of the knowledge structures behind the language means of N. I. Novikov's discourse. The paper highlights and interprets the components of the cognitive style of N. I. Novikov's discursive personality in correlation with his language consciousness. The methods of perception of the world by N. I. Novikov's discursive personality, the peculiarities of representation of the world's realities in discourse, and the manner of transmitting information about the world are determined. Personal preferences of a discursive person, as well as cognitive, semiological and motivational ones are revealed. It is proved that the features of N. I. Novikov's professional discursive personality are determined by the specifics of his cognitive style, objectified by cognitive and linguistic mechanisms of discursive activity. A definition of the concept of "cognitive style" is proposed. The components of cognitive style are interpreted as an element of theory for the analysis of a discursive personality. The role of cognitive style in the formation of a professional discursive personality of a journalist of the 18th century is determined.


2020 ◽  
pp. 5-13
Author(s):  
S. N. Volkov ◽  
D. A. Shapovalov ◽  
V. I. Nilipovskiy

This article analyzes the main problems of implementing programs for integrating efforts of the CIS countries in the fi eld of land management. The role of modern land administration in realization of the tasks of effective land resources management at the international level in the era of “big challenges” is shown in this paper. The authors considered the possibilities of CIS educational institutions in solving issues of geoinformation support of agro-industrial complex. New approaches and digital land management technologies that provide a signifi cant (up to 30%) increase in land use effi ciency are proposed here as well. The article notes necessity of new staff preparation in the branch in the context of digitalization based on the integration of human resource and potential of CIS educational institutions.


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