ESR1 gene polymorphism (rs827421) as a potential genetic marker for constitutional delay of growth and puberty in Egyptian adolescents

A melatonin receptor 1A (MTNR1A) gene polymorphism in adult buffaloes has been reported to affect reproductive seasonality. Consequently, the aim of the present study was to assess whether this polymorphism can affect age at first conception and the interval between first and second calving in Mediterranean Italian buffaloes. The allelic frequency of the C and T alleles was 0.44 and 0.56, respectively, whereas the genotypic frequency was 26% for C/C, 40% for C/T and 34% for T/T. The average age at first mating was approximately 20 months, whereas that at calving was approximately 32 months. The largest number of calvings of primiparous buffaloes was recorded between June and October. No associations between genotype, first mating and subsequent calving date were found. The duration from first to second calving was longer in buffaloes with the C/C genotype compared with those with the T/T and C/T genotypes (P < 0.01). The period of calving for buffaloes with the C/C genotype was mainly from July to September, whereas that for buffaloes with the T/T genotype was largely from March to May. The MTNR1A gene had no effect on the age of first conception in Mediterranean Italian buffaloes. Rather, the association between the T/T genotype and reproductive activity during days with a long photoperiod indicates that this polymorphism may be considered a genetic marker to identify buffaloes that are able to reproduce out of the breeding season.

Download Full-text

Association of ESR1 Gene Polymorphism with Preterm Rupture of Fetal Membranes

Bulletin of Experimental Biology and Medicine ◽

10.1007/s10517-014-2465-5 ◽

2014 ◽

Vol 156 (6) ◽

pp. 841-844 ◽

Cited By ~ 2

Author(s):

N. E. Kan ◽

V. L. Tyutyunnik ◽

A. E. Donnikov ◽

M. V. Sannikova ◽

G. T. Sukhikh

Keyword(s):

Gene Polymorphism ◽

Fetal Membranes ◽

Esr1 Gene

Download Full-text

FEATURES OF ESR1 GENE POLYMORPHISM IN WOMEN WITH PREECLAMPSY

Bulletin of Pirogov National Medical & Surgical Center ◽

10.25881/20728255_2021_16_2_58 ◽

2021 ◽

Vol 16 (2) ◽

pp. 58-60

Author(s):

B.B. KURBANOV ◽

D.D. KURBANOV ◽

Z.Z. IBRAGIMOV

Keyword(s):

Gene Polymorphism ◽

Esr1 Gene

Download Full-text

The PECAM-1 gene polymorphism — a genetic marker of myocardial infarction

Open Life Sciences ◽

10.2478/s11535-009-0042-0 ◽

2009 ◽

Vol 4 (4) ◽

pp. 515-520 ◽

Cited By ~ 2

Author(s):

Hrvoje Reschner ◽

Aleksandra Milutinovic ◽

Danijel Petrovič

Keyword(s):

Myocardial Infarction ◽

Gene Polymorphism ◽

Genetic Marker ◽

Serum Levels ◽

Control Group ◽

Genotype Distribution ◽

Cross Sectional ◽

Platelet Endothelial Cell Adhesion ◽

History Of ◽

Sectional Analysis

AbstractWe investigated a possible association between the C373G (Leu125Val) polymorphism in the platelet endothelial cell adhesion molecule-1 (PECAM-1) and myocardial infarction (MI) among patients with type 2 diabetes (T2DM) in the Slovene population (Caucasians). The study population of this cross-sectional analysis consisted of 452 subjects with T2DM lasting more than 10 years: 142 patients with MI (MI group) and 310 patients (control group) with no history of coronary diseases. There were significant differences of PECAM-1 genotype distribution in patients with MI (CC=28.2%, CG=47.2% and GG=24.6%) compared with subjects in the control group (CC=17.1%, CG=53.5% and GG=29.4%). The multivariate model showed that the CC genotype of the PECAM-1 gene polymorphism (C373G) (OR=1.9, 95% CI 1.2–3.0, P=0.007) was an independent risk factor for MI. The C allele frequency was also significantly higher (P=0.005) in MI (51.8%) than in control subjects (41%). In addition, our study revealed the connection between smoking habits, the duration of diabetes and the total and LDL cholesterol serum levels and MI in Slovene T2DM patients. We suggest that the tested polymorphism of PECAM-1 (C373G) is associated with MI. Therefore, it might be used as genetic marker of MI in T2DM.

Download Full-text

The ESR1 gene polymorphism is associated with the age of menarche in Russian women

Voprosy ginekologii akušerstva i perinatologii ◽

10.20953/1726-1678-2019-5-29-34 ◽

2019 ◽

Vol 18 (5) ◽

pp. 29-34 ◽

Cited By ~ 1

Author(s):

I.V. Ponomarenko ◽

◽

Е.А. Reshetnikov ◽

A.V. Polonikov ◽

I.N. Verzilina ◽

...

Keyword(s):

Gene Polymorphism ◽

Esr1 Gene ◽

Age Of Menarche

Download Full-text

Calcitonin Receptor Gene Polymorphism: A Possible Genetic Marker for Patients with Calcium Oxalate Stones

European Urology ◽

10.1159/000052532 ◽

2001 ◽

Vol 39 (6) ◽

pp. 716-719 ◽

Cited By ~ 16

Author(s):

Wen-Chi Chen ◽

Hsi-Chin Wu ◽

Hsueh-Fu Lu ◽

Huey-Yi Chen ◽

Fuu-Jen Tsai

Keyword(s):

Gene Polymorphism ◽

Calcium Oxalate ◽

Genetic Marker ◽

Receptor Gene ◽

Calcitonin Receptor ◽

Receptor Gene Polymorphism ◽

Calcium Oxalate Stones ◽

Calcitonin Receptor Gene

Download Full-text

ESTRADIOL BLOOD LEVEL AND ESR1 GENE POLYMORPHISM IN WOMEN WITH PREMENSTRUAL SYNDROME

Wiadomości Lekarskie ◽

10.36740/wlek202012105 ◽

2020 ◽

Vol 73 (12) ◽

pp. 2581-2585

Author(s):

Lyudmyla V. Pakharenko ◽

Yuri P. Vdovichenko ◽

Nataliia Ya. Kurtash ◽

Iryna O. Basiuha ◽

Inna V. Kravchuk ◽

...

Keyword(s):

Menstrual Cycle ◽

Gene Polymorphism ◽

Blood Level ◽

Premenstrual Syndrome ◽

Luteal Phase ◽

Healthy Women ◽

Esr1 Gene ◽

Polymerase Chain ◽

Two Phases ◽

Estradiol Concentration

The aim: To evaluate the association between estrogen receptor (ESR1) α- Xbal polymorphism with estradiol serum blood level in the patients with premenstrual syndrome. Materials and methods: 50 women with premenstrual syndrome and 20 controls were examined. The level of estradiol was measured in the blood serum in both phases of the menstrual cycle by ELISA method. Polymerase chain reaction was used to study ESR1 gene polymorphism (A-351G variant). Results: The estradiol concentration was similar in two phases of the menstrual cycle between healthy women and patients with premenstrual syndrome. But the more growth of estradiol in the luteal phase was determined in the persons with premenstrual syndrome. The rate of GG genotype was the largest in women with severe premenstrual syndrome (χ2=3.52, p=0.06). Also, in the persons with severe premenstrual syndrome who had G allele (GG+AG genotype) the estradiol concentration in the luteal phase of the menstrual cycle was on 50.00 % (p=0.02) higher compared to carriers of AA genotype. There was no difference in estradiol level between healthy women with GG+AG genotype and AA genotype. Conclusions: AG polymorphism of ESR1 gene may be the marker of development of premenstrual syndrome.

Download Full-text