scholarly journals ESTRADIOL BLOOD LEVEL AND ESR1 GENE POLYMORPHISM IN WOMEN WITH PREMENSTRUAL SYNDROME

2020 ◽  
Vol 73 (12) ◽  
pp. 2581-2585
Author(s):  
Lyudmyla V. Pakharenko ◽  
Yuri P. Vdovichenko ◽  
Nataliia Ya. Kurtash ◽  
Iryna O. Basiuha ◽  
Inna V. Kravchuk ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Gene Polymorphism ◽  
Blood Level ◽  
Premenstrual Syndrome ◽  
Luteal Phase ◽  
Healthy Women ◽  
Esr1 Gene ◽  
Polymerase Chain ◽  
Two Phases ◽  
Estradiol Concentration

The aim: To evaluate the association between estrogen receptor (ESR1) α- Xbal polymorphism with estradiol serum blood level in the patients with premenstrual syndrome. Materials and methods: 50 women with premenstrual syndrome and 20 controls were examined. The level of estradiol was measured in the blood serum in both phases of the menstrual cycle by ELISA method. Polymerase chain reaction was used to study ESR1 gene polymorphism (A-351G variant). Results: The estradiol concentration was similar in two phases of the menstrual cycle between healthy women and patients with premenstrual syndrome. But the more growth of estradiol in the luteal phase was determined in the persons with premenstrual syndrome. The rate of GG genotype was the largest in women with severe premenstrual syndrome (χ2=3.52, p=0.06). Also, in the persons with severe premenstrual syndrome who had G allele (GG+AG genotype) the estradiol concentration in the luteal phase of the menstrual cycle was on 50.00 % (p=0.02) higher compared to carriers of AA genotype. There was no difference in estradiol level between healthy women with GG+AG genotype and AA genotype. Conclusions: AG polymorphism of ESR1 gene may be the marker of development of premenstrual syndrome.

Haemodynamic responses to psychosocial stress during the menstrual cycle

1991 ◽  
Vol 81 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Karin Manhem ◽  
Christina Jern ◽  
Martin Pilhall ◽  
Guy Shanks ◽  
Sverker Jern
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Menstrual Cycle ◽  
Systolic Blood Pressure ◽  
Psychosocial Stress ◽  
Mental Stress ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Two Phases ◽  
Plasma Catecholamine Concentrations

1. The haemodynamic effects of hormonal changes during the menstrual cycle were examined in 11 normotensive women (age 20–46 years). The subjects were studied on days 2–8 (follicular phase) and days 18–26 (luteal phase) in a randomized order. A standardized mental stress test and a 24 h recording of ambulatory blood pressure and heart rate were performed. 2. Pre-stress resting levels of heart rate and blood pressure were similar during the two phases of the menstrual cycle. 3. During mental stress, the heart rate response was significantly greater during the luteal phase than during the follicular phase (14.7 versus 9.7 beats/min; P < 0.05). 4. Blood pressure, plasma catecholamine concentrations and subjective stress experience increased significantly in response to stress, without any significant differences between the two phases. 5. During 24 h ambulatory monitoring, higher levels of systolic blood pressure and heart rate were observed in the luteal phase than in the follicular phase (P < 0.005 and P < 0.0001, respectively). 6. These data indicate that cyclic variations in female sex hormones not only affect systolic blood pressure and heart rate, but also alter the haemodynamic responses to psychosocial stress.

Assessment of choroidal vascularity index during the menstrual cycle

2021 ◽  
pp. 112067212110576
Author(s):  
Nazife Aşikgarip ◽  
Emine Temel ◽  
Kemal Örnek
Keyword(s):  
Optical Coherence Tomography ◽  
Menstrual Cycle ◽  
Prospective Study ◽  
Luteal Phase ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Menstrual Cycles ◽  
Healthy Women ◽  
Luminal Area ◽  
Choroidal Structure

Purpose To explore the effect of menstrual cycle on choroidal vascularity index (CVI). Methods Thirty six eyes of 36 healthy women were included in this prospective study. The menstrual cycles were regular and ranged from 28 to 30 days in length. Optical coherence tomography images were obtained in 3 different phases of the menstrual cycle. The choroidal thickness (CT), total choroidal area, luminal area, stromal area, and CVI were quantified. Results Mean subfoveal, nasal and temporal CT were significantly changed in mid-luteal phase in comparison to early follicular (p = 0.018, p = 0.006 and p = 0.001, respectively) and ovulatory phases (p = 0.037, p = 0.037, and p = 0.035, respectively). Mean CVI showed a significant change in mid-luteal phase when compared with early follicular (p = 0.001) and ovulatory phases (p = 0.036). Conclusion CVI seemed to be affected in mid-luteal phase of menstrual cycle. This should be considered while analyzing choroidal structure in otherwise healthy women.

scholarly journals The Apoptotic, Angiogenic and Cell Proliferation Genes CD63, S100A6 e GNB2L1 are Altered in Patients with Endometriosis

2018 ◽  
Vol 40 (10) ◽  
pp. 606-613 ◽  
Author(s):  
Valéria Gomes ◽  
Camila Bonocher ◽  
Júlio Rosa-e-Silva ◽  
Cláudia de Paz ◽  
Rui Ferriani ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Menstrual Cycle ◽  
Case Control Study ◽  
Endometrial Biopsy ◽  
Gene Transcript ◽  
Eutopic Endometrium ◽  
Healthy Women ◽  
Paired Samples ◽  
Polymerase Chain ◽  
Control Study

Objective The aim of the present study was to analyze the expression of the CD63, S100A6, and GNB2L1genes, which participate in mechanisms related to the complex pathophysiology of endometriosis. Methods A case-control study was conducted with 40 women who were diagnosed with endometriosis, and 15 fertile and healthy women. Paired samples of eutopic endometrium and endometriotic lesions (peritoneal and ovarian endometriotic implants) were obtained from the women with endometriosis in the proliferative (n = 20) or secretory phases (n = 20) of the menstrual cycle. As controls, paired endometrial biopsy samples were collected from the healthy women in the proliferative (n = 15) and secretory (n = 15) phases of the same menstrual cycle. We analyzed the expression levels of the CD63, S100A6, and GNB2L1 genes by real-time polymerase chain reaction. Results An increase in CD63, S100A6, and GNB2L1 gene transcript levels was observed in the ectopic implants compared with the eutopic endometrium of the women with and without endometriosis, regardless of the phase of the menstrual cycle. Conclusion These findings suggest that the CD63, S100A6, and GNB2L1 genes may be involved in the pathogenesis of endometriosis, since they participate in mechanisms such as inhibition of apoptosis, angiogenesis and cell proliferation, which lead to the loss of cell homeostasis in the ectopic endometrium, thus contributing to the implantation and survival of the tissue in the extrauterine environment.

scholarly journals KLK3 as a possible novel early biomarker of environmental exposure in young women living in Polluted area

2021 ◽  
Author(s):  
Salvatore Raimondo ◽  
Mariacira Gentile ◽  
Giusy Esposito ◽  
Tommaso Gentile ◽  
Ida Ferrara ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Environmental Impact ◽  
Environmental Exposure ◽  
Luteal Phase ◽  
Prostate Gland ◽  
Environmental Pollutants ◽  
Biological Marker ◽  
Mean Values ◽  
Healthy Women ◽  
Early Biomarker

Abstract Background: Kallikrein Related Peptidase 3 (KLK3) is secreted by Skene's glands and, is considered ancestral homologues of the male prostate gland and has long been used as a biological marker of prostate cancer. Recent studies have shown that the synthesis of KLK3 can be induced by steroid hormones in different tissues of women and in the menstrual cycle it seems to follow the cyclic variation of estradiol and progesterone. In addition, some environmental pollutants such as bisphenols, phthalate / DBP (DiButyl Phthalate) affect AR (Androgen Receptors) mediated signalling that directly regulates KLK3 secretion. This suggests that environmental factors may play a role in KLK3 secretion.Methods: 61 healthy women living in a high environmental impact (HEI) area, 58 healthy women living in a low environmental impact (LEI) area were evaluated on possible presence or changes of KLK3 in serum at different phases of the menstrual cycle: blood samples taken in the follicular phase 5th-6th day, ovulatory phase 12th -13th day and luteal phase 19th -20th day of the menstrual cycle. For this aim, an ultra-sensitive kit for KLK3 with a detection limit of 0.001 ng / mL was used.Results KLK 3 values​​showed two opposite peaks, women from HEI had a positive peak in the ovulatory phase with mean value of 9.90 ± 3.21 pg / mL while women from LEI had a negative peak in the ovulatory phase with mean values ​​of 3.07 ± 1.49 pg / mL. Progesterone, showed a correlation with KLK3. Women from HEI had higher KLK3 values on average and no significant changes were evident between the three withdrawals in the different phases of the cycle. In contrast, women from LEI had a statistically significant decrease between the follicular and ovulatory phase (p <0.0001) and a statistically significant increase (p <0.0001) between the ovulatory and luteal phase.Conclusions: The data obtained seem to go beyond the known role of KLK3. The dosage of KLK3 during the various phases of the menstrual cycle, simple to carry out and with low costs, can represent an effective and early biomarker to assess environmental exposure and useful to recognize the risk early and protect female health, not only reproductive.

scholarly journals Relationship between Anxiety and Interleukin 10 in Female Soccer Players with and Without Premenstrual Syndrome (PMS)

2017 ◽  
Vol 39 (11) ◽  
pp. 602-607 ◽  
Author(s):  
Roberta Foster ◽  
Mauro Vaisberg ◽  
Maíta Araújo ◽  
Marcia Martins ◽  
Tiago Capel ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Premenstrual Syndrome ◽  
Luteal Phase ◽  
Pearson Correlation ◽  
Interleukin 10 ◽  
Soccer Players ◽  
Test Analysis ◽  
Symptom Report ◽  
Significance Level ◽  
Simulated Game

Objective To investigate the level of anxiety and its relationship with interleukin (IL)-10 (anti inflammatory cytokine that modulates mood swings) in a group of female soccer players. Methods Fifty-two eumenorrheic soccer players were evaluated (age 19.8 ± 4.7 years). The presence of premenstrual syndrome (PMS) and phases of the menstrual cycle were determined by a daily symptom report (DSR) kept for 3 consecutive months. The concentration of cytokine IL-10 was determined from urine samples collected at four moments: at the follicular and luteal phases of the menstrual cycle, and before (pre) and after (post) the simulated game, and it was quantified by flow cytometry (Luminex xMAP - EMD Millipore, Billerica, MA, USA). The level of anxiety was determined through the BAI anxiety questionnaire answered by all athletes at the same time of the urine collection. The Student t-test, analysis of variance (ANOVA) and Pearson correlation with significance level at 5% were used for data analysis. Results We showed that the prevalence of PMS among female soccer players is similar to that reported in the literature. In addition, we showed that the group with PMS has a higher level of anxiety compared with group without PMS (p = 0.002). Interleukin-10 analysis in players without PMS revealed that there was a significant decrease in the level of this cytokine before the game during the luteal phase when compared with the follicular phase (p < 0.05). The correlation analysis between IL-10 and anxiety showed a negative correlation post-game in the luteal phase in the group without PMS (p = 0.02; r = -0.50) and a positive correlation post-game in the luteal phase in PMS group (p = 0.04; r = 0.36). Conclusion Our results suggest that IL-10 may contribute to reduce anxiety in the group without PMS. This could be attributed to the fact that no IL-10 variation was observed in the group with PMS, which presented higher anxiety symptoms when compared with the group without PMS.

scholarly journals Genetic Variations of Brain Derived Neurotropic Factor Gene With Premenstrual Syndrome Among Pakistani Menarcheal Girls: A Pilot Study

BioSight ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 11-15
Author(s):  
Mehir un Nisa Iqbal ◽  
Fatima Noor ◽  
Taseer Khan
Keyword(s):  
Menstrual Cycle ◽  
Gene Polymorphism ◽  
Premenstrual Syndrome ◽  
Depression Scale ◽  
Rflp Analysis ◽  
World Health ◽  
P Value ◽  
Bdnf Gene ◽  
Emotional Symptoms ◽  
Salting Out

The premenstrual syndrome (PMS) comprises various physical and emotional symptoms which are associated with the menstrual cycle. The emotional changes might be due to the variation in the levels of BDNF especially lower levels of plasma BDNF may be present at the luteal phase of menstrual cycle. To date, no data were present to associate the link between BDNF gene polymorphism and PMS among young Menarcheal females. So, the goal of this investigation is to find out the possible relationship between BDNF gene polymorphism and PMS among young Menarcheal females of Pakistan. A total of 92 menarcheal girls with age range of 11-14yrs met the inclusion criteria. All participants were screened for the depression and PMS using Zung’s depression scale/ Diagnostic and Statistical Manual of Mental Disorders-IV (DSM IV) criteria and world health organization (WHO) criteria for PMS respectively. Genomic DNA was extracted from oral samples by Salting out method and BDNF genotyping was done using PCR-RFLP analysis. Results showed no significant association (χ2=1.685, p-value=0.431) was observed between BDNF genotyping and PMS among menarcheal girls. BDNF (rs6265) AA and GA genotypes did not show significant association with the risk of PMS. Hence, it was concluded that BDNF gene polymorphism may not be associated with the PMS among Pakistani Menarcheal girls

scholarly journals Neuroactive steroid-serotonergic interaction: responses to an intravenous L-tryptophan challenge in women with premenstrual syndrome

2001 ◽  
pp. 25-33 ◽  
Author(s):  
N Rasgon ◽  
M Serra ◽  
G Biggio ◽  
MG Pisu ◽  
L Fairbanks ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Body Mass ◽  
Premenstrual Syndrome ◽  
Luteal Phase ◽  
Neuroactive Steroids ◽  
Serotonergic System ◽  
Neuroactive Steroid

OBJECTIVE: To evaluate the circulating concentrations of the neuroactive steroids in response to an i.v. L-tryptophan (L-TP) challenge across the menstrual cycle in women with premenstrual syndrome (PMS) and in controls. METHOD: An i.v. L-TP challenge was administered eight times during 1 month to five women with prospectively documented PMS and five age- and body mass-matched controls. Progesterone, allopregnanolone pregnenolone and 3alpha-5alpha-tetrahydrocorticosterone were assessed 15 and 0 min before, and at 30, 60 and 90 min after the challenge, across the menstrual cycle. RESULTS: In response to L-TP challenge, only allopregnanolone concentrations were significantly increased across the cycle and this increase was of a greater magnitude in women with PMS. Pregnenolone and 3alpha-5alpha-tetrahydrocorticosterone concentrations were not affected in women with PMS or controls after L-TP challenge. CONCLUSIONS: The data provide evidence for possible interaction between the serotonergic system and the neuroactive steroid, allopregnanolone. Women with PMS demonstrated a more significant increase in allopregnanolone concentrations in response to L-TP challenge, which could be due to an initial low basal serotonergic tone in the luteal phase in the PMS group.

scholarly journals HUBUNGAN ANTARA HIPERTENSI DENGAN PREMENSTRUAL SYNDROME PADA WANITA USIA REPRODUKTIF

Biomedika ◽  
2014 ◽  
Vol 6 (2) ◽  
Author(s):  
Azhim Rahmawati ◽  
Retno Siryaningsih ◽  
Safari Wahyu Jatmiko
Keyword(s):  
Risk Factor ◽  
Menstrual Cycle ◽  
Medical Care ◽  
Premenstrual Syndrome ◽  
Luteal Phase ◽  
Reproductive Age ◽  
Physical Disturbance ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

Premenstrual syndrome (PMS) is a cycle disorder which is commonly occured during the luteal phase of the menstrual cycle and will dissapear at the time of menstruation. Ninety percent of women on reproductive ages experience symptomps of PMS and 10% of them experience severe premenstrual symptomps that cuse physical disturbance, medical care necessity, even worst death. Hypertension is a risk factor for a PMS. The aim of this research is to find out a conection between PMS and hypertension. This research was designated using analytic observational with cross sectional approach. We used purposive sampling to get sample. Based on sample formula, we got 104 respondents which is consist of 52 women with hypertension and 52 women normotensive. To obtain data, we used shortened premenstrual syndrome assesment form (SPAF). Data collected were analyzed by chi square test. The result showed that the value of p = 0.00 (p<0.005). This result indicated that there is a conection between hypertension and PMS occurence in reproductive age. The probability of hypertension women to get PMS is 6.75.Keywords: Hypertension, Premenstrual Syndrome, reproductive age

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