Candesartan protects against d-galactose induced – Neurotoxicity and memory deficit via modulation of autophagy and oxidative stress

2021 ◽  
pp. 115827
Author(s):  
Naglaa F. Khedr ◽  
Rehab H. Werida ◽  
Mariam A. Abo-Saif
Keyword(s):  
Oxidative Stress ◽  
Memory Deficit ◽  
And Oxidative Stress

Chitosan-coated rosmarinic acid nanoemulsion nasal administration protects against LPS-induced memory deficit, neuroinflammation, and oxidative stress in Wistar rats

2020 ◽  
Vol 141 ◽  
pp. 104875
Author(s):  
Flávia Nathiely Silveira Fachel ◽  
Luana Roberta Michels ◽  
Juliana Hofstätter Azambuja ◽  
Gabriela Spies Lenz ◽  
Nicolly Espindola Gelsleichter ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rosmarinic Acid ◽  
Wistar Rats ◽  
Memory Deficit ◽  
Nasal Administration ◽  
And Oxidative Stress

scholarly journals NEUROPROTECTIVE EFFECT OF WATERMELON (CITRULLUS LANATUS) PULP JUICE ON SCOPOLAMINE-INDUCED MEMORY DEFICITS IN SWISS ALBINO MICE: THE ROLE OF ACETYLCHOLINESTERASE AND OXIDATIVE STRESS

2021 ◽  
Vol 12 (3) ◽  
pp. 52-56
Author(s):  
Divya N ◽  
Amudha P ◽  
Viveka K Priya
Keyword(s):  
Oxidative Stress ◽  
Ache Activity ◽  
Citrullus Lanatus ◽  
Neuroprotective Effect ◽  
Memory Deficits ◽  
Memory Deficit ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

The effect of Watermelon (Citrullus lanatus) Pulp Juice (WPJ) on scopolamine (SCOP) induced memory deficits is due to the involvement of oxidative stress and AChE activity. The juice was obtained by crushing the pulp in blender and three different concentrations of 100%, 50% and 25% was administration to prevent memory deficit by evaluating changes of AChE activity and oxidative stress indicators (SOD, CAT, LPO and GPx) induced by scopolamine. These results provide evidence that WPJ is an alternative to protect SCOP induced memory deficits in mice by involvement of oxidative stress and AChE activity.

scholarly journals Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson’s disease

2019 ◽  
Vol 77 (7) ◽  
pp. 493-500 ◽  
Author(s):  
Leila HAMZEHLOEI ◽  
Mohammad Ebrahim REZVANI ◽  
Ziba RAJAEI
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Lipid Peroxidation ◽  
Parkinson's Disease ◽  
Treadmill Exercise ◽  
Memory Deficit ◽  
Rotational Behavior ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
And Oxidative Stress

ABSTRACT The present study was undertaken to investigate the effects of carvacrol and treadmill exercise on memory deficit, rotational behavior and oxidative stress biomarkers in a 6-OHDA-lesioned rat model of Parkinson’s disease. Wistar rats were treated with carvacrol at a dose of 25 mg/kg and/or ran on a treadmill for a week. Then, 6-OHDA was microinjected into the medial forebrain bundle and treatments continued for six more weeks. Aversive memory, rotational behavior and oxidative stress biomarkers were assessed at the end of week six. The 6-OHDA-lesioned group showed a significant increase in rotational behavior and a decrease in step-through latency in the passive avoidance test compared with the sham group. These behaviors were accompanied by increased lipid peroxidation levels and decreased total thiol concentration in the striatum and/or hippocampus of the hemiparkinsonian rats. Moreover, treatment with carvacrol and exercise reduced rotational behavior and improved aversive memory deficit, which was accompanied by decreased lipid peroxidation levels and increased total thiol concentration in the striatum and/or hippocampus. In conclusion, treatment with carvacrol and treadmill exercise ameliorated motor and memory deficits by modulating oxidative stress in the striatum and hippocampus of hemiparkinsonian rats. Therefore, the combination of carvacrol and treadmill exercise could be an effective therapeutic tool for treatment of neurobehavioral deficits in Parkinson’s disease patients.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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