Quantification of anthelmintic drug residues in milk and muscle tissues by liquid chromatography coupled to Orbitrap and liquid chromatography coupled to tandem mass spectrometry

Talanta ◽  
2011 ◽  
Vol 85 (2) ◽  
pp. 991-1000 ◽  
Author(s):  
A. Kaufmann ◽  
P. Butcher ◽  
K. Maden ◽  
S. Walker ◽  
M. Widmer
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass ◽  
Drug Residues ◽  
Anthelmintic Drug ◽  
Muscle Tissues

Development and Validation of a Multiclass Method for the Analysis of Veterinary Drug Residues in Eggs Using Liquid Chromatography-Tandem Mass Spectrometry

2016 ◽  
Vol 10 (4) ◽  
pp. 1063-1077 ◽  
Author(s):  
Flávia Lada Degaut Pontes ◽  
João Cleverson Gasparetto ◽  
Thais Martins Guimarães de Francisco ◽  
Heloise Calzado Goetzke ◽  
Letícia Paula Leonart ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Veterinary Drug ◽  
Tandem Mass ◽  
Veterinary Drug Residues ◽  
Drug Residues ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Development And Validation

scholarly journals Determination of Anthelmintic and Antiprotozoal Drug Residues in Fish Using Liquid Chromatography-Tandem Mass Spectrometry

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2575
Author(s):  
Eunjung Kim ◽  
Sihyun Park ◽  
Hyunjin Park ◽  
Jangduck Choi ◽  
Hae-Jung Yoon ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass ◽  
Drug Residues ◽  
Simple Modification ◽  
Chromatography Tandem Mass Spectrometry ◽  
Limit Of Quantitation ◽  
Liquid Chromatography Tandem Mass

The objective of this study is to develop a comprehensive and simple method for the simultaneous determination of anthelmintic and antiprotozoal drug residues in fish. For sample preparation, we used the “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) method with a simple modification. The sample was extracted with water and 1% formic acid in acetonitrile/methanol (MeCN/MeOH) (95:5, v/v), followed by phase separation (salting out) with MgSO4 and NaCl (4:1, w/w). After centrifugation, an aliquot of the extract was purified by dispersive solid-phase extraction (d-SPE) prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The method was validated at three concentration levels for all matrices, in accordance with the Codex guidelines (CAC/GL-71). Quantitative analysis was performed using the method of matrix-matched calibration. The recoveries were between 60.6% and 119.9%, with coefficients of variation (CV) <30% for all matrices. The limit of quantitation (LOQ) of the method ranged from 0.02 μg kg−1 to 4.8 μg kg−1 for all matrices. This comprehensive method can be used for the investigation of both anthelmintic and antiprotozoal drugs belonging to different chemical families in fishery products.

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