Highly sensitive impedimetric immunosensor for determination of interleukin 6 as a cancer biomarker by using conjugated polymer containing epoxy side groups modified disposable ITO electrode

Talanta ◽  
2020 ◽  
Vol 215 ◽  
pp. 120909 ◽  
Author(s):  
Elif Burcu Aydın
Keyword(s):  
Interleukin 6 ◽  
Conjugated Polymer ◽  
Cancer Biomarker ◽  
Ito Electrode ◽  
Highly Sensitive ◽  
Impedimetric Immunosensor

scholarly journals Determination of L-Argininamide Based on Water-Soluble Fluorescent Conjugated Polymer-Aptamer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Hongliang Guan ◽  
Zhike He
Keyword(s):  
Conjugated Polymer ◽  
Specific Binding ◽  
Water Soluble ◽  
Dna Sensor ◽  
Label Free ◽  
Binding Reaction ◽  
Molecular Sensors ◽  
Free Dna ◽  
Highly Sensitive

Water-soluble fluorescent conjugated polymer is a promising material which could be used as an optical platform in highly sensitive molecular sensors. In this paper, a simple label-free DNA sensor, which consisted of a poly(3-alkoxy-4-methylthiophene) and an aptamer, was used to detect L-argininamide (L-Arm). Due to the specific binding reaction between L-Arm and its aptamer, the proposed method can easily determinate the L-Arm through the recovery of fluorescence without any modification. Other ions or similar molecules had little effect on the detection. Moreover, there was a linear relationship between fluorescence intensity and the concentration of L-Arm. The detection limit of L-Arm was as low as 4.7 nM.

scholarly journals Highly sensitive electrochemical determination of captopril using CuO modified ITO electrode: the effect of in situ grown nanostructures over signal sensitivity

RSC Advances ◽  
2017 ◽  
Vol 7 (31) ◽  
pp. 19353-19362 ◽  
Author(s):  
Razium Ali Soomro ◽  
Mawada Mohamed Tunesi ◽  
Selcan Karakus ◽  
Nazar Kalwar
Keyword(s):  
Electrochemical Determination ◽  
Ito Electrode ◽  
Highly Sensitive ◽  
Signal Sensitivity ◽  
Electrochemical Signal

Influence of nanostructures distribution over electrochemical signal sensitivity.

Controlled Growth and Characterization Ag/ZnO Nanotetrapods for Humidity Sensing

2018 ◽  
Vol 21 (7) ◽  
pp. 462-467
Author(s):  
Babak Sadeghi
Keyword(s):  
Room Temperature ◽  
Zinc Complex ◽  
Water Solution ◽  
Particle Morphology ◽  
Quick Response ◽  
Separation System ◽  
Humidity Sensing ◽  
Sensor Material ◽  
Highly Sensitive

Aim and Objective: Ultrafine Ag/ZnO nanotetrapods (AZNTP) have been prepared successfully using silver (I)–bis (oxalato) zinc complex and 1, 3-diaminopropane (DAP) with a phase separation system, and have been injected into a diethyl/water solution. Materials and Methods: This crystal structure and lattice constant of the AZNTP obtained were investigated by means of a SEM, XRD, TEM and UV-vis spectrum. Results: The results of the present study demonstrated the growth and characterization AZNTP for humidity sensing and DAP plays a key role in the determination of particle morphology. AZNTP films with 23 nm in arm diameter have shown highly sensitive, quick response sensor material that works at room temperature.

Simultaneous Determination of Methocarbamol and Paracetamol in the Presence of Three Related Substances by Ultra Performance Liquid Chromatography

2019 ◽  
Vol 15 (5) ◽  
pp. 505-510
Author(s):  
Yanjuan Zheng ◽  
Qiushi Peng ◽  
Rui Dong ◽  
Tingyu Chen ◽  
Yi Bao ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Pharmaceutical Preparations ◽  
Gradient Elution ◽  
Ultra Performance Liquid Chromatography ◽  
Related Substances ◽  
Bulk Powder ◽  
Highly Sensitive ◽  
Optimal Protocol ◽  
Acquity Uplc

Introduction: A rapid, and accurate Ultra Performance Liquid Chromatography (UPLC) method was developed to simultaneously analyze Methocarbamol, Paracetamol and the related substances Materials and Methods: Waters ACQUITY UPLC® BEH Phenyl C18 column was used in conjunction with UV detection at 225nm. Gradient elution with 0.05M, pH 6 phosphate buffer and acetonitrile flow at 0.3mL /min rate were used to separate the substances. The retention times for 4-Aminopheno, Paracetamol, Guaifenesin, Methocarbamol, and 4-Chloroacetanilide were 1.319 minute, 2.224 minute, 4.467 minute, 4.769 minute and 5.433 minute respectively. The concentration was linear in the range of 2-100 µg/ml for Methocarbamol, and 1-100 µg/mL for Paracetamol. The percentage recoveries were between 99.28±1.23% to 100.57±0.99% for Methocarbamol, and between 99.08±1.23% to 101.23±1.39% for Paracetamol. Results and Discussion: The validated optimal protocol is robust and accurate for simultaneous analysis of Methocarbamol, Paracetamol and the related substances, applicable for bulk powder as well as pharmaceutical formulation. Conclusion: In this paper, a highly sensitive, accurate, and precise UPLC method with UV-Vis detection was developed and validated for quality control of MET and PAR in bulk as well as in pharmaceutical preparations.

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