S-methyl cysteine sulfoxide ameliorates duodenal morphological alterations in streptozotocin-induced diabetic rats

2020 ◽  
pp. 101483
Author(s):  
Valéria Milena Dantas de Castro ◽  
Karina Carla de Paula Medeiros ◽  
Licyanne Ingrid Carvalho de Lemos ◽  
Lucia de Fátima Campos Pedrosa ◽  
Fernando Vagner Lobo Ladd ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Morphological Alterations ◽  
Cysteine Sulfoxide

S-methyl cysteine sulfoxide mitigates histopathological damage, alleviate oxidative stress and promotes immunomodulation in diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Licyanne Ingrid C. Lemos ◽  
Matheus Anselmo Medeiros ◽  
João Paulo M.S. Lima ◽  
Tatiane O. Teixeira ◽  
Camila Alexandrina Figueiredo ◽  
...  
Keyword(s):  
Oral Treatment ◽  
Low Density Lipoprotein ◽  
Antioxidant Properties ◽  
Density Lipoprotein ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Histopathological Analysis ◽  
Morphological Alterations ◽  
Liver And Pancreas ◽  
Cysteine Sulfoxide

Abstract Objectives S-methyl cysteine sulfoxide (SMCS) is a hydrophilic cysteine-containing natural compound found in plants and is known to possess antidiabetic and antioxidant properties. We investigated the antioxidant and immunomodulatory properties of SMCS, as well as histopathological changes in the liver and pancreas in streptozotocin (STZ)-induced diabetic rats. Methods The rats were divided into the following groups: control (CG), comprising non-diabetic rats; STZ-DB, comprising STZ-induced diabetic rats; and STZ-SMCS, comprising STZ-induced diabetic rats treated with SMCS. SMCS (200 mg/kg) was administered by gavage daily for 30 days. Biochemical and cytokine analyses, catalase (CAT) and superoxide dismutase (SOD) activities assays and histopathological analysis of liver and pancreas tissues were performed. Results SMCS treatment reduced glycemia (p<0.05), decreased triglyceride (p<0.01) and very-low-density lipoprotein (VLDL) levels (p<0.01), and increased SOD and CAT activity in the liver (both p<0.01) compared with STZ-DB group. Higher activity values of IL-10 were observed in the STZ-SMCS group than in the other groups (p<0.001). Liver glycogen was significantly improved in the STZ-SMCS group compared with the STZ-DB group. SMCS also ameliorated damage to pancreatic islets, which resulted in restoration of their morphology. Conclusions Oral treatment of SMCS showed improvement of the morphological alterations in liver and pancreatic islet in diabetic rats. These beneficial morphological effects of SMCS can be partially explained by IL-10 modulation associated with antioxidant action.

scholarly journals Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats

2008 ◽  
Vol 23 (suppl 1) ◽  
pp. 53-58 ◽  
Author(s):  
Antonio Antunes Rodrigues Jr ◽  
Haylton Jorge Suaid ◽  
Silvio Tucci Jr ◽  
Valéria Paula Sassoli Fazan ◽  
Milton César Foss ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Muscle Layer ◽  
Diabetic Rats ◽  
Bladder Pressure ◽  
Morphological Alterations ◽  
Bladder Compliance ◽  
Bladder Contraction ◽  
Functional Patterns ◽  
Term Evaluation

PURPOSE: to evaluate structural and functional effects of Alloxan- induced diabetes and aging on bladder of rats. METHODS: evaluations were performed in three groups: A - 8 weeks of age, B - 44 weeks of age, C - 44 weeks of age with alloxan-induced diabetes. Muscle layer thickness, extracellular matrix fibrosis and collagen were quantified on digital images of bladder samples. Cystometric evaluations before surgical vesical denervation (SVD), included maximum cystometric capacity (MCC), maximum bladder pressure (MBP), bladder contraction frequency (VCF), duration of bladder contraction (DC), threshold pressure (TP) and bladder compliance (BC). After SVD, maximum cystometric capacity (MCC), BC and maximum urethral closing pressure (MUCP) were also measured. RESULTS: Reduced extracellular matrix fibrosis concentration and contraction strength were found in the bladders of group C. Before SVD, bladder compliance was not different between groups. Alterations were observed in MCC after SVD. CONCLUSIONS: We did not notice smooth muscle hypertrophy in Alloxan-induced diabetic rats after 44 weeks. There was alteration in the total and relative amount of fibrosis and collagen. The cystometric studies support the idea that this morphological alterations are important to determine the different bladder functional patterns found in the aging and the Alloxan-induced diabetic animals.

scholarly journals α-Lipoic Acid Increases Collagen Synthesis and Deposition in Nondiabetic and Diabetic Rat Kidneys

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Nevena Grdović ◽  
Jovana Rajić ◽  
Jelena Arambašić Jovanović ◽  
Svetlana Dinić ◽  
Anja Tolić ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Collagen Synthesis ◽  
Structural Integrity ◽  
Transforming Growth Factor ◽  
Diabetes Management ◽  
Smooth Muscle Actin ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Morphological Alterations ◽  
Tgf Β1

α-Lipoic acid (ALA) is widely used as a nutritional supplement and therapeutic agent in diabetes management. Well-established antioxidant and hypoglycemic effects of ALA were considered to be particularly important in combating diabetic complications including renal injury. The present study evaluated the potential of ALA to affect profibrotic events in kidney that could alter its structure and functioning. ALA was administered intraperitoneally (10 mg/kg) to nondiabetic and streptozotocin-induced diabetic male Wistar rats for 4 and 8 weeks. The effects of ALA were assessed starting from structural/morphological alterations through changes that characterize profibrotic processes, to regulation of collagen gene expression in kidney. Here, we demonstrated that ALA improved systemic glucose and urea level, reduced formation of renal advanced glycation end products (AGEs), and maintained renal structural integrity in diabetic rats. However, profibrotic events provoked in diabetes were not alleviated by ALA since collagen synthesis/deposition and expression of transforming growth factor-β1 (TGF-β1) and α-smooth muscle actin (α-SMA) remained elevated in ALA-treated diabetic rats, especially after 8 weeks of diabetes onset. Moreover, 8 weeks treatment of nondiabetic rats with ALA led to the development of profibrotic features reflected in increased collagen synthesis/deposition. Besides the TGF-β1 downstream signaling, the additional mechanism underlying the upregulation of collagen IV in nondiabetic rats treated with ALA involves decreased DNA methylation of its promoter that could arise from increased Tet1 expression. These findings emphasize the therapeutic caution in the use of ALA, especially in patients with renal diabetic complication.

scholarly journals Structural and Ultrastructural Analysis of Cerebral Cortex, Cerebellum, and Hypothalamus from Diabetic Rats

2009 ◽  
Vol 2009 ◽  
pp. 1-12 ◽  
Author(s):  
Juan P. Hernández-Fonseca ◽  
Jaimar Rincón ◽  
Adriana Pedreañez ◽  
Ninoska Viera ◽  
José L. Arcaya ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Depressive Mood ◽  
Diabetic Rats ◽  
Ultrastructural Changes ◽  
Central Nervous System Damage ◽  
Morphological Alterations ◽  
Brain Functions ◽  
Structural Abnormalities ◽  
Streptozotocin Induced Diabetes ◽  
Presynaptic Vesicle

Autonomic and peripheral neuropathies are well-described complications in diabetes. Diabetes mellitus is also associated to central nervous system damage. This little-known complication is characterized by impairment of brain functions and electrophysiological changes associated with neurochemical and structural abnormalities. The purpose of this study was to investigate brain structural and ultrastructural changes in rats with streptozotocin-induced diabetes. Cerebral cortex, hypothalamus, and cerebellum were obtained from controls and 8 weeks diabetic rats. Light and electron microscope studies showed degenerative changes of neurons and glia, perivascular and mitochondrial swelling, disarrangement of myelin sheath, increased area of myelinated axons, presynaptic vesicle dispersion in swollen axonal boutoms, fragmentation of neurofilaments, and oligodendrocyte abnormalities. In addition, depressive mood was observed in diabetic animals. The brain morphological alterations observed in diabetic animals could be related to brain pathologic process leading to abnormal function, cellular death, and depressive behavioral.

Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats

2013 ◽  
Vol 95 (2) ◽  
pp. 389-397 ◽  
Author(s):  
R.M. Maciel ◽  
M.M. Costa ◽  
D.B. Martins ◽  
R.T. França ◽  
R. Schmatz ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Morphological Alterations ◽  
Anti Inflammatory

scholarly journals Novel pentacyclic triterpene isolated from seeds of Euryale Ferox Salisb. ameliorates diabetes in streptozotocin induced diabetic rats

2018 ◽  
Vol 11 (4) ◽  
pp. 275-288 ◽  
Author(s):  
Danish Ahmed ◽  
Mohd. Ibrahim Khan ◽  
Manju Sharma ◽  
Mohd. Faiyaz Khan
Keyword(s):  
Glycemic Control ◽  
Plasma Insulin ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Active Principle ◽  
Pentacyclic Triterpene ◽  
Morphological Alterations ◽  
Euryale Ferox ◽  
Liver And Kidney ◽  
Glucose 6 Phosphate Dehydrogenase

Abstract The present research was carried out to study the effect of 2β-hydroxybetulinic acid 3β-oleiate (HBAO), a novel compound isolated from the seeds of Euryale ferox salisb. on glycemic control, antioxidant status and histopathological morphological alterations in the liver, pancreas, kidney and heart in streptozotocin induced type-2 diabetes in rats. HBAO was isolated from the seeds of Euryale ferox salisb. according to Lee. Isolation of the active principle HBAO was performed for the first time. To date there are no reports on the isolation and evaluation of 2β-hydroxybetulinic acid 3β-oleiate (HBAO) from Euryale ferox salisb. Assessment of different biochemical parameters like the effect of HBAO on glycemic control, plasma insulin, glycosylated hemoglobin, hepatic glucose-6-phosphate dehydrogenase, glucose-6-phosphatase and fructose-1-6-biphosphatase, hepatic hexokinase, lipid profile, antioxidant marker and histopathology of pancreas, liver and kidney examination was done at the end of the experimentation, i.e. on day 45. HBAO exhibited remarkable improvement in glycemic control, lipid levels, plasma insulin, glycogenic liver enzymes and antioxidant activity in diabetic rats, along with progressive enhancement of distortive histopathological morphology of liver, pancreas and kidney. The results strongly suggest that HBAO could be a potential therapeutic agent in diabetes.

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