Safety issues of botanicals and botanical preparations in functional foods

Toxicology ◽  
2004 ◽  
Vol 198 (1-3) ◽  
pp. 213-220 ◽  
Author(s):  
R Kroes ◽  
R Walker
2015 ◽  
Vol 98 (3) ◽  
pp. 739-741 ◽  
Author(s):  
Guenther Silbernagel ◽  
Iris Baumgartner ◽  
Winfried März

Abstract Plant sterols and stanols as components of functional foods are widely used for cholesterol lowering. The regular intake of these functional foods is associated with a decrease in low density lipoprotein cholesterol of about 10 % and an increase in plasma plant sterol or stanol concentrations by about a factor of 2. There is no doubt that a decrease in low density lipoprotein cholesterol is beneficial to cardiovascular health. However, due to the concomitant increase in circulating plant sterols safety issues associated with the intake of plant sterol containing functional foods have been raised. Herein, we will review and evaluate those arguments raised against the use of plant sterols and stanols.


2018 ◽  
Vol 4 ◽  
Author(s):  
Larry Holbrook ◽  
Michael Kani

Until recently, consumer perception of cannabis was largely framed by its stigma surrounding drug use. Today, in an era of medical and recreational cannabis legalization, an increasing commercialization of cannabis-based products are being purported as functional foods. It is important for a wider audience of researchers, health care professionals, regulators and industry stakeholders to enhance their awareness of the human endocannabinoid system as a physiological regulator, the safety issues of product and process methods and adherence to qualitycontrolled training programs for assuring the public of safe practices.


2020 ◽  
Vol 21 (5) ◽  
pp. 1862
Author(s):  
Thi Lien Ngo ◽  
Chung-Hee Lee ◽  
Nayoung Han ◽  
Hyun-Moon Back ◽  
Su-Jin Rhee ◽  
...  

Duloxetine (DLX) is a potent drug investigated for the treatment of depression and urinary incontinence. DLX is extensively metabolized in the liver by two P450 isozymes, CYP2D6 and CYP1A2. Propolis (PPL) is one of the popular functional foods known to have effects on activities of CYPs, including CYP1A2. Due to the high probability of using DLX and PPL simultaneously, the present study was designed to investigate the potent effect of PPL on pharmacokinetics (PKs) of DLX after co-administration in humans. A PK study was first conducted in 18 rats (n = 6/group), in which the plasma concentration of DLX and its major metabolite 4-hydroxy duloxetine (4-HD) with or without administration of PPL was recorded. Population PKs and potential effects of PPL were then analyzed using NONMEM software. Lastly, these results were extrapolated from rats to humans using the allometric scaling and the liver blood flow method. PPL (15,000 mg/day) exerts a statistically significant increase in DLX exposures at steady state, with a 20.2% and 24.6% increase in DLX C m a x , s s and the same 28.0% increase in DLX A U C s s when DLX (40 or 60 mg) was administered once or twice daily, respectively. In conclusion, safety issues are required to be attended to when individuals simultaneously use DLX and PPL at high doses, and the possibility of interactions between DLX and PPL might be noted.


2005 ◽  
Vol 36 (9) ◽  
pp. 50-51
Author(s):  
BRUCE JANCIN

2012 ◽  
Vol 82 (3) ◽  
pp. 144-147 ◽  
Author(s):  
Ibrahim Elmadfa ◽  
Alexa L. Meyer

A high-quality diet is one of the foundations of health and well-being. For a long time in human history, diet was chiefly a source of energy and macronutrients meant to still hunger and give the strength for work and activities that were in general much harder than nowadays. Only few persons could afford to emphasize enjoyment. In the assessment of quality, organoleptic properties were major criteria to detect spoilage and oxidative deterioration of food. Today, food hygiene is a quality aspect that is often taken for granted by consumers, despite its lack being at the origin of most food-borne diseases. The discovery of micronutrients entailed fundamental changes of the concept of diet quality. However, non-essential food components with additional health functions were still barely known or not considered important until recently. With the high burden of obesity and its associated diseases on the rise, affluent, industrialized countries have developed an increased interest in these substances, which has led to the development of functional foods to optimize special body functions, reduce disease risk, or even contribute to therapeutic approaches. Indeed, nowadays, high contents of energy, fat, and sugar are factors associated with a lower quality of food, and products with reduced amounts of these components are valued by many consumers. At the same time, enjoyment and convenience are important quality factors, presenting food manufacturers with the dilemma of reconciling low fat content and applicability with good taste and appealing appearance. Functional foods offer an approach to address this challenge. Deeper insights into nutrient-gene interactions may enable personalized nutrition adapted to the special needs of individuals. However, so far, a varied healthy diet remains the best basis for health and well-being.


2012 ◽  
Author(s):  
Scott Ryan ◽  
◽  
Megan Dove-Steinkamp ◽  
Suzanne Nobrega ◽  
Lize Tibirica ◽  
...  

2010 ◽  
Vol 40 (16) ◽  
pp. 13
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  

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