Ethanol impedes embryo transport and impairs oviduct epithelium

Toxicology ◽  
2016 ◽  
Vol 357-358 ◽  
pp. 44-51 ◽  
Author(s):  
Tonghui Xu ◽  
Qiuhong Yang ◽  
Ruoxi Liu ◽  
Wenfu Wang ◽  
Shuanglian Wang ◽  
...  
Keyword(s):  
Oviduct Epithelium ◽  
Embryo Transport

scholarly journals Appendectomy and women’s reproductive outcomes: a review of the literature

2021 ◽  
Author(s):  
Lucia Merlino ◽  
Alessandra Chiné ◽  
Giulia Carletti ◽  
Federica Del Prete ◽  
Massimo Codacci Pisanelli ◽  
...  
Keyword(s):  
Large Population ◽  
Fluid Secretion ◽  
Reproductive Period ◽  
Pelvic Surgery ◽  
Tubal Infertility ◽  
Peritoneal Adhesions ◽  
Relevant Risk Factor ◽  
Perforated Appendix ◽  
Embryo Transport ◽  
Possible Cause

Summary Background The most frequent abdominal surgery performed for benign disease in females of fertile age is appendectomy, which remains among the most common surgeries and is a possible cause of peritoneal adhesions. The fact that appendectomy can cause adhesions may lead one to think that this may be a relevant risk factor for infertility; however, there is no universal agreement regarding the association between appendectomy and fertility. The aim of this review is to evaluate weather appendectomy may have a relevant impact on female fertility. Methods The search was conducted in PubMed and there was no limitation set on the date of publication. All studies regarding populations of female patients who had undergone appendectomy for inflamed appendix, perforated appendix, or negative appendix between childhood and the end of the reproductive period were included. Results Some authors believe that pelvic surgery can cause adhesions which can potentially lead to tubal infertility by causing tubal obstruction or by altering motility of fimbriae, tubal fluid secretion, and embryo transport. On the other hand, the most recent evidence reported that removal of the appendix seems to be associated with an increased pregnancy rate in large population studies. Conclusion Despite the existence of contrasting opinions concerning fertility after appendectomy, the most recent evidence suggests that appendectomy may actually lead to improved fertility and decreased time to pregnancy. Appendectomy seems to be correlated with improved fertility and higher pregnancy rates.

scholarly journals Further investigation of the role of progesterone in the control of embryo transport in the mouse

Reproduction ◽  
1985 ◽  
Vol 73 (1) ◽  
pp. 279-283 ◽  
Author(s):  
K. L. Grieve ◽  
J. M. Henwood ◽  
K. E. Kendle
Keyword(s):  
Embryo Transport

scholarly journals Ultrastructural and immunohistochemical study of the basal apparatus of solitary cilia in the human oviduct epithelium

2002 ◽  
Vol 200 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Haruo Hagiwara ◽  
Shinsuke Harada ◽  
Sakae Maeda ◽  
Takeo Aoki ◽  
Nobuo Ohwada ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Oviduct Epithelium ◽  
Basal Apparatus ◽  
Human Oviduct

In vivo gene transfer to the mouse oviduct epithelium

1998 ◽  
Vol 70 (2) ◽  
pp. 366-368 ◽  
Author(s):  
Miguel Relloso ◽  
Pedro Esponda
Keyword(s):  
Gene Transfer ◽  
Oviduct Epithelium ◽  
In Vivo Gene Transfer

scholarly journals Seminal Plasma Triggers the Differential Expression of the Glucocorticoid Receptor (NR3C1/GR) in the Rabbit Reproductive Tract

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2158
Author(s):  
Mateo Ruiz-Conca ◽  
Jaume Gardela ◽  
Amaia Jauregi-Miguel ◽  
Cristina A. Martinez ◽  
Heriberto Rodríguez-Martinez ◽  
...  
Keyword(s):  
Differential Expression ◽  
Seminal Plasma ◽  
Time Course ◽  
Reproductive Tract ◽  
Receptor Gene ◽  
Early Embryo ◽  
Female Reproductive Tract ◽  
Relevant Role ◽  
Morula Stage ◽  
Embryo Transport

Rabbits are interesting as research animal models for reproduction, due to their condition of species of induced ovulation, with the release of endogenous gonadotropin-releasing hormone (GnRH) due to coitus. Glucocorticoid (GC) signaling, crucial for physiological homeostasis, is mediated through a yet unclear mechanism, by the GC receptor (NR3C1/GR). After mating, the female reproductive tract undergoes dynamic modifications, triggered by gene transcription, a pre-amble for fertilization and pregnancy. This study tested the hypothesis that when ovulation is induced, the expression of NR3C1 is influenced by sperm-free seminal plasma (SP), similarly to after mating (whole semen), along the different segments of the internal reproductive tract of female rabbits. Semen (mating) was compared to vaginal infusion of sperm-free SP (Experiment 1), and changes over time were also evaluated, i.e., 10, 24, 36, 68, and 72 h post-mating, corresponding to specific stages, i.e., ovulation, fertilization, and the interval of early embryo development up to the morula stage (Experiment 2). All does were treated with GnRH to induce ovulation. Samples were retrieved from seven segments of the reproductive tract (from the cervix to infundibulum), at 20 h post-mating or sperm-free SP infusion (Experiment 1) or at 10, 24, 36, 68, and 72 h post-mating (Experiment 2). Gene expression of NR3C1 was analyzed by qPCR. Results showed an increase in NR3C1 expression in the infundibulum compared to the other anatomical regions in the absence of spermatozoa when sperm-free SP infusion was performed (Experiment 1). Moreover, during the embryo transport through the oviduct, the distal isthmus was time-course upregulated, especially at 72 h, when morulae are retained in this anatomical region, while it was downregulated in the distal uterus at 68 h (Experiment 2). The overall results suggest that NR3C1, the GC receptor gene, assessed in the reproductive tract of does for the first time, shows differential expression changes during the interval of oviductal and uterine embryo transport that may imply a relevant role of the GC action, not only close to the site of ovulation and fertilization, but also in the endometrium.

Effect of early ovariectomy and steroid hormone replacement of embryo transport, development and implantation in mice

1991 ◽  
Vol 3 (1) ◽  
pp. 35 ◽  
Author(s):  
A Vinijsanun ◽  
L Martin
Keyword(s):  
Embryo Development ◽  
Preimplantation Embryo ◽  
Surgical Stress ◽  
Hormone Replacement ◽  
Surgical Trauma ◽  
Embryo Viability ◽  
Preimplantation Embryo Development ◽  
Bilateral Ovariectomy ◽  
Embryo Transport ◽  
Implantation Rates

Bilateral ovariectomy on Day 1 of pregnancy increased abnormal embryo numbers on Day 4 and delayed passage of embryos to the uterus. Progestins given on Day 1 reversed these effects; given on Day 3 they reduced numbers of abnormal embryos, but did not restore normal transport. Oestrogen given alone after ovariectomy increased embryo loss, but restored preimplantation embryo development to normal when given on Day 3 after progestins on Day 1. The results suggested that both oestrogen and progesterone were necessary for normal preimplantation embryo development in vivo. However, although Day-1 progestins produced the greatest improvement in embryo transport and preimplantation development, they supported only low implantation rates compared with progestins starting on Day 3, and no progestin treatment returned implantation rates to normal. Sham ovariectomy on Day 1 also reduced implantation rate, suggesting that surgical stress of Day-1 ovariectomy had major adverse effects on embryo viability. This view was supported by experiments involving unilateral ovariectomy, which produced abnormalities in embryo transport, development and implantation, but only on the operated side. Furthermore, the major abnormality induced in embryo development by unilateral and bilateral ovariectomy, viz embryonic autolysis, was not increased in experiments in which pregnancy was blocked by non-surgical antagonism of progesterone. It is concluded that abnormalities in embryo development induced by early ovariectomy are not caused by a deficit of endogenous hormones, but result largely from effects of surgical trauma on oviduct function which can be reversed by treatment with exogenous hormones.

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