Immunosuppresive role of principal toxin (crotoxin) of Crotalus durissus terrificus venom

AbstractTo understand the role of peptidases in seminal physiology ofCrotalus durissus terrificus, activity levels of representative enzymes in semen and their sensitivities to inhibitors, cofactors, and peptide hormones were evaluated. The existence of seminal fractions and the association of peptidases with these fractions were also characterized for the first time in snakes. The prominent inhibitors of aminopeptidases (APs) were amastatin for acid, basic, and neutral; bestatin for basic; and diprotin A for dipeptidyl-IV. Cystyl and prolyl-imino APs were similarly susceptible to the majority of these inhibitors. The basic and neutral were characterized as metallo-peptidases, acid AP was activated by MnCl2, and cystyl, prolyl-imino, and type I pyroglutamyl were characterized as sulphydryl-dependent APs. Angiotensin II, vasotocin, bradykinin, fertilization-promoting peptide, and TRH altered the majority of these peptidase activities; these peptides are possible substrates and/or modulators of these peptidases. Peptidase activities were found in all seminal fractions: seminal plasma (SP), prostasome-like (PR) structures, and soluble (S-) and membrane-bound fractions (MFs) of spermatozoa. The levels of activity of each peptidase varied among different seminal fractions. In SP, the higher activities were puromycin-insensitive neutral and basic APs. In PR, the higher activity was puromycin-insensitive neutral AP. In spermatozoa, the higher activity in subcellular SF was puromycin-sensitive neutral, while in MF both puromycin-sensitive and -insensitive neutral APs were equally higher than the other examined peptidases. Data suggested that these peptidases, mainly basic and neutral, have a high relevance in regulating seminal functions ofC. d. terrificus.

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The role of nitric oxide in the regulation of the systemic and pulmonary vasculature of the rattlesnake, Crotalus durissus terrificus

Journal of Comparative Physiology B ◽

10.1007/s00360-005-0476-2 ◽

2005 ◽

Vol 175 (3) ◽

pp. 201-208 ◽

Cited By ~ 21

Author(s):

Gina LJ Galli ◽

Nini Skovgaard ◽

Augusto S. Abe ◽

Edwin W. Taylor ◽

Tobias Wang

Keyword(s):

Nitric Oxide ◽

Pulmonary Vasculature ◽

Crotalus Durissus Terrificus ◽

Crotalus Durissus

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Role of a Novel Tetrodotoxin-Resistant Sodium Channel in the Nitrergic Relaxation of Corpus Cavernosum from the South American Rattlesnake Crotalus Durissus Terrificus

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2011.02246.x ◽

2011 ◽

Vol 8 (6) ◽

pp. 1616-1625 ◽

Cited By ~ 10

Author(s):

Rodrigo O. Capel ◽

Fabíola Z. Mónica ◽

Marcovan Porto ◽

Samuel Barillas ◽

Marcelo Nicolás Muscará ◽

...

Keyword(s):

Sodium Channel ◽

Corpus Cavernosum ◽

South American ◽

The South ◽

Crotalus Durissus Terrificus ◽

Crotalus Durissus

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Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions

Mediators of Inflammation ◽

10.1080/09629350124986 ◽

2001 ◽

Vol 10 (3) ◽

pp. 125-133 ◽

Cited By ~ 29

Author(s):

Diva F. Cardoso ◽

Monica Lopes-Ferreira ◽

Eliana L. Faquim-Mauro ◽

Mahasti S. Macedo ◽

Sandra H. P. Farsky

Keyword(s):

Phospholipase A2 ◽

Snake Venom ◽

Immune Reactions ◽

Crotalus Durissus Terrificus ◽

Crotalus Durissus

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Pengembangan Minat Baca Peserta Didik : Studi Peran Kepala Sekolah

IJER (Indonesian Journal of Educational Research) ◽

10.30631/ijer.v2i2.42 ◽

2018 ◽

Vol 2 (2) ◽

pp. 84

Author(s):

Fahrurrrazi Fahrurrrazi

Keyword(s):

Descriptive Analysis ◽

Field Research ◽

Learning Ability ◽

Analysis Technique ◽

Role Of Principal ◽

Strategic Role ◽

Management Functions ◽

Reading Interest

Penelitian ini dilatarbelakangi oleh fenomena minat baca siswa dan pengaruh minat baca terhadap pertumbuhan kemampuan belajar siswa pada jenjang-jenjang pendidikan selanjutnya. Kepala sekolah sebagai lokomotif perkembangan mutu pendidikan memiliki peran strategi bagi pengumbuhan dan pengembangan minat baca peserta didik. Penelitian ini bertujuan untuk mengetahui peran kepala madrasah sebagai edukator, manajer, dan innovator dalam pengembangan minat baca peserta didik di MIT Nurul Islam Kota Semarang. Penelitian ini merupakan penelitian kualitatif lapangan, data dikumpulkan melalui observasi, wawancara, dokumentasi dan triangulasi, serta dianalisis dengan teknik analisis deskriptif. Hasil penelitian ini menunjukkan bahwa: 1) Peran kepala madrasah sebagai edukator dalam pengembangan minat baca peserta didik meliputi meliputi tiga pembinaan, yakni pembinaan mental dan moral, serta pembinaan artistik. 2) Peran kepala madrasah sebagai manajer dalam pengembangan minat baca peserta didik di MIT Nurul Islam meliputi penerapan fungsi-fungsi manajemen dengan didasarkan pada pada kerjasama dengan USAID dan UIN Walisongo Semarang. 3) Peran kepala madrasah sebagai innovator dalam pengembangan minat baca peserta didik di MIT Nurul Islam Kota Semarang meliputi inovasi strategi, pola pikir (mindset) dan struktur. Abstract This research is motivated by the phenomenon of reading interest of students and the influence of reading interest on the growth of students' learning ability in the next level of education. The principal as a locomotive of the development of the quality of education has a strategic role for the growth and development of reading interest of learners. This study aims to determine the role of principal as an educator, manager, and innovator in the development of reading interest of learners in MIT Nurul Islam Semarang City. This research is a qualitative field research, data collected through observation, interview, documentation and triangulation, and analyzed by descriptive analysis technique. The results of this study indicate that: 1) The role of principal as an educator in the development of reading interest of learners includes three activities are coaching, namely mental and moral coaching, and artistic coaching. 2) The role of principal as manager in the development of reading interest of learners at MIT Nurul Islam covers the application of management functions based on cooperation with USAID and UIN Walisongo Semarang. 3) The role of principal as innovator in the development of reading interest of learners at MIT Nurul Islam Semarang City includes innovation strategy, mindset, and structure.

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COVID-19 and Teachers’ Somatic Burden, Stress, and Emotional Exhaustion: Examining the Role of Principal Leadership and Workplace Buoyancy

AERA Open ◽

10.1177/2332858420986187 ◽

2021 ◽

Vol 7 ◽

pp. 233285842098618

Author(s):

Rebecca J. Collie

Keyword(s):

Principal Leadership ◽

Emotional Exhaustion ◽

Work Situation ◽

Supportive Leadership ◽

Personal Resource ◽

Role Of Principal

The role of two leadership factors (autonomy-supportive and autonomy-thwarting leadership) and one personal resource (workplace buoyancy) were examined as predictors of three teacher outcomes: somatic burden, stress related to change, and emotional exhaustion. Data were collected from 325 Australian teachers in May, 2020 during the first wave of COVID-19. During this time, many Australian children were being taught remotely from home, while other students were attending schools in-person. Findings showed that autonomy-supportive leadership was associated with greater buoyancy and, in turn, lower somatic burden, stress related to change, and emotional exhaustion (while controlling for covariates, including COVID-19 work situation). Autonomy-thwarting leadership was positively associated with emotional exhaustion. In addition, autonomy-supportive leadership was indirectly associated with the outcomes. The findings provide understanding of factors that may be harnessed to support teachers during subsequent waves of COVID-19 and other future disruptions to schooling that may occur.

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