Caffeic acid protects against DNA damage, oxidative and inflammatory mediated toxicities, and upregulated caspases activation in the hepatorenal system of rats treated with aflatoxin B1

Toxicon ◽  
2022 ◽  
Vol 207 ◽  
pp. 1-12
Author(s):  
Solomon E. Owumi ◽  
Chioma E. Irozuru ◽  
Uche O. Arunsi ◽  
Adegboyega K. Oyelere
Keyword(s):  
Dna Damage ◽  
Caffeic Acid ◽  
Aflatoxin B1

Effects of Amaranthus cruentus L. on aflatoxin B1- and oxidative stress-induced DNA damage in human liver (HepG2) cells

2018 ◽  
Vol 26 ◽  
pp. 42-48 ◽  
Author(s):  
Grace A. Odongo ◽  
Nina Schlotz ◽  
Susanne Baldermann ◽  
Susanne Neugart ◽  
Benard Ngwene ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Aflatoxin B1 ◽  
Hepg2 Cells ◽  
Human Liver ◽  
Amaranthus Cruentus ◽  
And Oxidative Stress

Protective Effects of Coffee Against Induction of DNA Damage and Cancer by Aflatoxin B1

2015 ◽  
pp. 587-596
Author(s):  
Franziska Ferk ◽  
Karl Speer ◽  
Miroslav Mišík ◽  
Armen Nersesyan ◽  
Siegfried Knasmüller
Keyword(s):  
Dna Damage ◽  
Aflatoxin B1 ◽  
Protective Effects

scholarly journals Genome Profiling for Aflatoxin B1 Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B1-Associated DNA Damage

2020 ◽  
Vol 10 (11) ◽  
pp. 3929-3947
Author(s):  
Nick St. John ◽  
Julian Freedland ◽  
Henri Baldino ◽  
Francis Doyle ◽  
Cinzia Cera ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Adducts ◽  
Aflatoxin B1 ◽  
Yeast Genome ◽  
Actin Reorganization ◽  
Functionally Diverse ◽  
Next Generation Sequencing Ngs ◽  
Pooled Samples ◽  
Sister Chromatid Recombination ◽  
Human Cyp1a2

Exposure to the mycotoxin aflatoxin B1 (AFB1) strongly correlates with hepatocellular carcinoma (HCC). P450 enzymes convert AFB1 into a highly reactive epoxide that forms unstable 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 (AFB1-N7-Gua) DNA adducts, which convert to stable mutagenic AFB1 formamidopyrimidine (FAPY) DNA adducts. In CYP1A2-expressing budding yeast, AFB1 is a weak mutagen but a potent recombinagen. However, few genes have been identified that confer AFB1 resistance. Here, we profiled the yeast genome for AFB1 resistance. We introduced the human CYP1A2 into ∼90% of the diploid deletion library, and pooled samples from CYP1A2-expressing libraries and the original library were exposed to 50 μM AFB1 for 20 hs. By using next generation sequencing (NGS) to count molecular barcodes, we initially identified 86 genes from the CYP1A2-expressing libraries, of which 79 were confirmed to confer AFB1 resistance. While functionally diverse genes, including those that function in proteolysis, actin reorganization, and tRNA modification, were identified, those that function in postreplication DNA repair and encode proteins that bind to DNA damage were over-represented, compared to the yeast genome, at large. DNA metabolism genes also included those functioning in checkpoint recovery and replication fork maintenance, emphasizing the potency of the mycotoxin to trigger replication stress. Among genes involved in postreplication repair, we observed that CSM2, a member of the CSM2(SHU) complex, functioned in AFB1-associated sister chromatid recombination while suppressing AFB1-associated mutations. These studies thus broaden the number of AFB1 resistance genes and have elucidated a mechanism of error-free bypass of AFB1-associated DNA adducts.

scholarly journals Aflatoxin B1-Induced Developmental and DNA Damage in Caenorhabditis elegans

Toxins ◽  
2016 ◽  
Vol 9 (1) ◽  
pp. 9 ◽  
Author(s):  
Wei-Hong Feng ◽  
Kathy Xue ◽  
Lili Tang ◽  
Phillip Williams ◽  
Jia-Sheng Wang
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Aflatoxin B1

Caffeic acid phenethyl ester modulates aflatoxin B1-induced hepatotoxicity in rats

2013 ◽  
Vol 31 (8) ◽  
pp. 692-697 ◽  
Author(s):  
Mustafa Akçam ◽  
Reha Artan ◽  
Aygen Yilmaz ◽  
Sebahat Ozdem ◽  
Tekinalp Gelen ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Aflatoxin B1 ◽  
Caffeic Acid Phenethyl Ester

Aflatoxin B1 and aflatoxin M1 induced cytotoxicity and DNA damage in differentiated and undifferentiated Caco-2 cells

2015 ◽  
Vol 83 ◽  
pp. 54-60 ◽  
Author(s):  
J. Zhang ◽  
N. Zheng ◽  
J. Liu ◽  
F.D. Li ◽  
S.L. Li ◽  
...  
Keyword(s):  
Dna Damage ◽  
Aflatoxin B1 ◽  
Aflatoxin M1
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