In vivo immunoprotective role of Indigofera tinctoria and Scoparia dulcis aqueous extracts against chronic noise stress induced immune abnormalities in Wistar albino rats

Aim: In cyclosporin-A (CsA)-induced toxicity, oxidative stress has been implicated as a potential responsible mechanism. Therefore, we aimed to investigate the protective role of erdosteine against CsA-induced nephrotoxicity in terms of tissue oxidant/antioxidant parameters and light microscopy in rats. Materials and methods: Wistar albino rats were randomly separated into four groups. Group 1 rats treated with sodium chloride served as the control, group 2 rats were treated with CsA, group 3 with CsA plus erdosteine, and group 4 with erdosteine alone. Animals were killed and blood samples were analyzed for blood urea nitrogen (BUN), serum creatinine (Cr), uric acid (UA), total protein (TP), and albumin (ALB) levels. Kidney sections were analyzed for malondialdehyde (MDA) and nitric oxide (NO) levels and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities, as well as for histopathological changes. Results: In the CsA group, MDA, GSH-Px, BUN, and Cr levels were increased. The TP and ALB levels were decreased. These changes had been improved by erdosteine administration. Other biochemical parameters did not show any significant change. Conclusion: These results indicate that erdosteine produces a protective mechanism against CsA-induced nephrotoxicity and suggest a role of oxidative stress in pathogenesis.

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Alteration in memory and electroencephalogram waves with sub-acute noise stress in albino rats and safeguarded by Scoparia dulcis

Pharmacognosy Magazine ◽

10.4103/0973-1296.176119 ◽

2016 ◽

Vol 12 (45) ◽

pp. 7 ◽

Cited By ~ 3

Author(s):

Sheeladevi Rathinasamy ◽

Sundareswaran Loganathan

Keyword(s):

Albino Rats ◽

Noise Stress ◽

Scoparia Dulcis

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Neuroprotective role of Glycyrrhiza glabra on chronic noise induced changes in Hippocampal morphology and its functions in wistar albino rats

International Journal of Ayurvedic Medicine ◽

10.47552/ijam.v12i3.1871 ◽

2021 ◽

Vol 12 (2) ◽

pp. 226-231

Author(s):

Archana Arjunan ◽

Dhiraj Kumar Sah ◽

Ravindran Rajan

Keyword(s):

Neuroprotective Effect ◽

Hippocampal Volume ◽

Glycyrrhiza Glabra ◽

Albino Rats ◽

Behavioral Alterations ◽

Obsessive Compulsive ◽

Noise Stress ◽

Wistar Albino Rats ◽

Fear And Anxiety ◽

Hippocampal Morphology

Background: Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of Glycyrrhiza glabra (GG) on stress-induced male Wistar albino rats. Methods: Adult albino rats were randomly divided into four groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h – 30Days), Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p<0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behaviour, enlarged lateral ventricle, and reduced hippocampal volume. Conclusion: The results reported that chronic noise stress affects the neurobehavioral due to reduced hippocampal volume.

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In-vivo hypoglycemic and hypolipidemic properties of Tagetes lucida alcoholic extract in streptozotocin-induced hyperglycemic Wistar albino rats

Annals of Agricultural Sciences ◽

10.1016/j.aoas.2017.11.005 ◽

2017 ◽

Vol 62 (2) ◽

pp. 169-181 ◽

Cited By ~ 3

Author(s):

Samah A. Abdel-Haleem ◽

Abeer Y. Ibrahim ◽

Rasha F. Ismail ◽

Nermeen M. Shaffie ◽

S.F. Hendawy ◽

...

Keyword(s):

Albino Rats ◽

Alcoholic Extract ◽

Wistar Albino Rats

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EVALUATION OF HEPATOPROTECTIVE EFFECTS OF SELECTED FRUIT PEEL EXTRACTS AND THEIR POLY HERBAL MIXTURE ON CCL4 INDUCED HEPATOTOXICITY: AN IN VIVO STUDY

INDIAN DRUGS ◽

10.53879/id.57.09.12110 ◽

2020 ◽

Vol 57 (09) ◽

pp. 67-74

Author(s):

Gana Manjusha Kondepudi ◽

Battu Ganga Rao ◽

P Balakrishnaiah

Keyword(s):

Hepatoprotective Activity ◽

Serum Markers ◽

Albino Rats ◽

Dependent Manner ◽

Fruit Peel ◽

Herbal Mixture ◽

Wistar Albino Rats ◽

Dose Dependent ◽

Peel Extract

The main aim of this study was to screen the selected fruit peel extracts and their polyherbal mixture (PHM) for hepatoprotective activity. Male wistar albino rats (180-200 g), divided into 12 groups after induction of hepatotoxicity, were treated with selected fruit peel extracts and PHM and at the end of 14th day blood and liver samples were collected and analysed. The aqueous peel extract of Malus pumila was a better hepatoprotective among the selected peel extracts. The activities might be due to the conditioning of hepatocytes by protecting the integrity of the membrane from CCl4 induced leakage of serum markers into circulation. All the selected plant extracts and PHM were shown to revert back the liver enzymes to the normal values in diseased rats in a dose dependent manner. In conclusion, the selected fruit peel extracts and poly herbal mixture can be a potent hepatoprotective agent due to their antioxidant and anti-inflammatory actions.

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