Transfection of Hairpin Small Interfering RNA Expression Vector Targeting Rat Nuclear Factor (NF) (κB) Inhibits Rat Cell Proliferation Induced by NF-κB Signal Pathway Activation

2010 ◽  
Vol 42 (10) ◽  
pp. 4633-4637 ◽  
Author(s):  
X.P. He ◽  
X.X. Li ◽  
Z.H. Wang ◽  
Y.W. Bi ◽  
F.Y. Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Small Interfering Rna ◽  
Expression Vector ◽  
Signal Pathway ◽  
Rna Expression ◽  
Nuclear Factor ◽  
Pathway Activation ◽  
Vector Targeting ◽  
Interfering Rna

scholarly journals Single small-interfering RNA expression vector for silencing multiple transforming growth factor-  pathway components

2005 ◽  
Vol 33 (15) ◽  
pp. e131-e131 ◽  
Author(s):  
A. Jazag ◽  
F. Kanai ◽  
H. Ijichi ◽  
K. Tateishi ◽  
T. Ikenoue ◽  
...  
Keyword(s):  
Growth Factor ◽  
Small Interfering Rna ◽  
Expression Vector ◽  
Transforming Growth Factor ◽  
Rna Expression ◽  
Interfering Rna

scholarly journals RNA Interference of Human Papillomavirus Type 18 E6 and E7 Induces Senescence in HeLa Cells

2003 ◽  
Vol 77 (10) ◽  
pp. 6066-6069 ◽  
Author(s):  
Allison H. S. Hall ◽  
Kenneth A. Alexander
Keyword(s):  
Cell Proliferation ◽  
Human Papillomavirus ◽  
Rna Interference ◽  
Hela Cells ◽  
Tumor Suppressors ◽  
Small Interfering Rna ◽  
Promote Cell Proliferation ◽  
E6 And E7 ◽  
Cellular Dna ◽  
Interfering Rna

ABSTRACT The human papillomavirus oncoproteins E6 and E7 promote cell proliferation and contribute to carcinogenesis by interfering with the activities of cellular tumor suppressors. We used a small interfering RNA molecule targeting the E7 region of the bicistronic E6 and E7 mRNA to induce RNA interference, thereby reducing expression of E6 and E7 in HeLa cells. RNA interference of E6 and E7 also inhibited cellular DNA synthesis and induced morphological and biochemical changes characteristic of cellular senescence. These results demonstrate that reducing E6 and E7 expression is sufficient to cause HeLa cells to become senescent.

scholarly journals Lentivirus-delivered nemo-like kinase small interfering RNA inhibits laryngeal cancer cell proliferation in vitro

2015 ◽  
Vol 12 (4) ◽  
pp. 5619-5624
Author(s):  
JUN TAI ◽  
YUANSHENG RAO ◽  
JUGAO FANG ◽  
ZHIGANG HUANG ◽  
ZHENKUN YU ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Laryngeal Cancer ◽  
Small Interfering Rna ◽  
Cancer Cell Proliferation ◽  
Interfering Rna ◽  
Proliferation In Vitro
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