Association Between Urothelial Carcinoma After Kidney Transplantation and Aristolochic Acid Exposure: The Potential Role of Aristolochic Acid in HRas and TP53 Gene Mutations

2011 ◽  
Vol 43 (10) ◽  
pp. 3751-3754 ◽  
Author(s):  
J. Xiao ◽  
X. Zhu ◽  
G.Y. Hao ◽  
Y.C. Zhu ◽  
H.J. Hou ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Urothelial Carcinoma ◽  
Potential Role ◽  
Aristolochic Acid ◽  
Gene Mutations ◽  
Tp53 Gene ◽  
Acid Exposure ◽  
Tp53 Gene Mutations

1068: TP53 Gene Mutations as a Prognostic Marker for PSA Progression in Early Stage Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 282-282
Author(s):  
Markus D. Sachs ◽  
Horst Schlechte ◽  
Katrin Schiemenz ◽  
Severin V. Lenk ◽  
Dietmar Schnorr ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Marker ◽  
Early Stage ◽  
Gene Mutations ◽  
Tp53 Gene ◽  
Psa Progression ◽  
Tp53 Gene Mutations

scholarly journals Molecular Markers in Upper Urothelial Carcinoma Associated to Balkan Endemic Nephropathy. Aristolochic Acid as the Major Risk Factor of the Worldwide Disease

2009 ◽  
Vol 9 ◽  
pp. 1360-1373 ◽  
Author(s):  
Ljubinka Jankovic Velickovic ◽  
Takanori Hattori ◽  
Vladisav Stefanovic
Keyword(s):  
Regression Analysis ◽  
Urothelial Carcinoma ◽  
Growth Stage ◽  
Aristolochic Acid ◽  
Balkan Endemic Nephropathy ◽  
Specific Cell ◽  
Ki 67 ◽  
High Stage ◽  
Endemic Nephropathy

The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper urothelial carcinoma (UUC) was recently confirmed. The aim of this study was to determine the marker(s) specific for BEN-associated UUC. A total of 82 patients with UUC (38 from the BEN region and 44 control tumors) were included in the study. The Ki-67 index in BEN tumors correlated with the grade and multifocality (p< 0.05), but in regression analysis, only the grade of BEN tumor. The p53 index was significantly higher in BEN than in control tumors (p< 0.05), as well as the alteration of p53 (p< 0.05). BEN low-stage tumors, tumors without limphovascular invasion (LVI), and tumors of the renal pelvis had a higher p53 index than the control tumors (p< 0.05, 0.01, 0.05, respectively). The Ki-67 index was higher in control tumors with high-stage and solid growth than in BEN UUC (p < 0.050, 0.005). The Ki-67 correlated with the grade, growth, stage, LVI, and multifocality of UUC on the best way, but not with the group. In regression analysis, only multifocality of UUC had predictive influence on Ki-67 activity (p< 0.001). P53 correlated with the grade, growth, and group (p< 0.05). This investigation identifies the p53 pathway as the specific cell cycle marker involved in BEN-associated UUC.

scholarly journals TP53 Gene Mutations in Tumor Cells of Patients with Aggressive B-Cell Lymphomas

2019 ◽  
Vol 12 (3) ◽  
pp. 263-270
Author(s):  
AE Misyurina ◽  
◽  
SK Kravchenko ◽  
VA Misyurin ◽  
AM Kovrigina ◽  
...  
Keyword(s):  
B Cell ◽  
Tumor Cells ◽  
Gene Mutations ◽  
Tp53 Gene ◽  
B Cell Lymphomas ◽  
Tp53 Gene Mutations

Demonstration of p53 protein and TP53 gene mutations in oligodendrogliomas

1996 ◽  
Vol 32 (13) ◽  
pp. 2242-2248 ◽  
Author(s):  
C. Hagel ◽  
G. Laking ◽  
R. Laas ◽  
S. Scheil ◽  
R. Jung ◽  
...  
Keyword(s):  
P53 Protein ◽  
Gene Mutations ◽  
Tp53 Gene ◽  
Tp53 Gene Mutations

Abstract 2413: TP53 gene mutations differently regulate ovarian cancer metabolism: Ex vivo and in vitro studies

2018 ◽  
Author(s):  
Stephanie Antoun ◽  
David Atallah ◽  
Roula Tahtouh ◽  
Malak Moubarak ◽  
Nada Alaeddine ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Metabolism ◽  
Ex Vivo ◽  
Gene Mutations ◽  
Tp53 Gene ◽  
In Vitro Studies ◽  
Tp53 Gene Mutations
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