scholarly journals The potential effects of deploying SARS-Cov-2 vaccines on cold storage capacity and immunization workload in countries of the WHO African Region

Vaccine ◽  
2021 ◽  
Vol 39 (15) ◽  
pp. 2165-2176
Author(s):  
Justin R. Ortiz ◽  
Joanie Robertson ◽  
Jui-Shan Hsu ◽  
Stephen L. Yu ◽  
Amanda J. Driscoll ◽  
...  
2020 ◽  
Author(s):  
Justin R. Ortiz ◽  
Joanie Robertson ◽  
Jui-Shan Hsu ◽  
Stephen L. Yu ◽  
Amanda J. Driscoll ◽  
...  

ABSTRACTBackgroundWhen available, SARS-CoV-2 vaccines will be deployed to countries with limited immunization systems.MethodsWe conducted an immunization capacity assessment of a simulated WHO African Region country using region-specific data on immunization, population, healthcare workers (HCWs), vaccine cold storage capacity (quartile values for national and subnational levels), and characteristics of influenza vaccines to represent future SARS-CoV-2 vaccines. We calculated monthly increases in vaccine doses, doses per vaccinator, and cold storage volumes for four-month SARS-CoV-2 vaccination campaigns targeting risk groups compared to routine immunization baselines.FindingsAdministering SARS-CoV-2 vaccines to risk groups would increase total monthly doses by 27.0% for ≥65 years, 91.7% for chronic diseases patients, and 1.1% for HCWs. Assuming median nurse density estimates adjusted for absenteeism and proportion providing immunization services, SARS-CoV-2 vaccination campaigns would increase total monthly doses per vaccinator by 29.3% for ≥65 years, 99.6% for chronic diseases patients, and 1.2% for HCWs. When we applied quartiles of actual African Region country vaccine storage capacity, routine immunization vaccine volumes exceeded national-level storage capacity for at least 75% of countries, but subnational levels had sufficient storage capacity for SARS-CoV-2 vaccines for at least 75% of countries.InterpretationIn the WHO African Region, SARS-CoV-2 vaccination campaigns would substantially increase doses per vaccinator and cold chain capacity requirements over routine immunization baselines. Pandemic vaccination campaigns would add volume to national-level stores already at their limits, but sufficient capacity exists at subnational levels. Immediate attention to strengthening immunization systems is essential to support pandemic responses.FundingNone


1987 ◽  
Vol 16 (2) ◽  
pp. 123-129
Author(s):  
Ralph E. Bierlen ◽  
David Blandford

Canadian exports of fresh carrots to the United States have increased substantially in recent years. The depreciation of the Canadian dollar against the U.S. dollar has been a major factor. Canadian government subsidies also may have had an impact by accelerating the construction of cold storage facilities. These have permitted the marketing period to be extended. However, an analysis of costs and returns suggests that cold storage of carrots is commercially profitable. Storage capacity would probably have increased without government aid. The returns to storage and the change in exchange rates are the primary factors contributing to the expansion of Canadian exports.


2021 ◽  
Vol 1098 (6) ◽  
pp. 062109
Author(s):  
W Widodo ◽  
S Syafrizal ◽  
A I Tuvana ◽  
M I Subekti ◽  
L Nulhakim

2019 ◽  
Vol 28 (6) ◽  
pp. 1195-1204
Author(s):  
Zhifeng Sun ◽  
Yaohua Zhao ◽  
Wei Xu ◽  
Dongxu Wang ◽  
Huiyong Li ◽  
...  

2018 ◽  
Vol 9 (1) ◽  
pp. 64-69
Author(s):  
Cristiano Hossel ◽  
Jéssica Scalet Alves de Oliveira Hossel ◽  
Américo Wagner Júnior ◽  
Marcelo Dotto ◽  
Kelli Pirola ◽  
...  

The objective of this study was to evaluate the viability of ‘jabuticaree açu’ [Plinia cauliflora (DC.) Berg] seeds according to water loss and packaging conservation conditions. Two experiments were carried out at UTFPR - Dois Vizinhos Campus, Parana State, Brazil. For the first experiment, the seeds were submitted to the hydro conditioning process by soaking in water during 24 hours with subsequently storage in a BOD chamber at 25°C for 0, 12, 24, 36, 48, 60, 72, 84 and 96 hours. This experiment was conducted in a completely randomized design with four replications of 50 seeds each. For the second experiment the seeds were separated into three lots: PET® bottles with lids, kraft® paper bags at room temperature and in cold storage (6°C±1°C). Each lot was stored during 0, 5, 10, 15, 20, 25, 30, 60, 90, 120 and 150 days. The experiment was carried out in a completely randomized design, in a 3x11 factorial (storage location x storage period), with four repetitions of 50 seeds each. Plinia cauliflora seeds present storage capacity of 96 hours at room temperature without loss of germination capacity, when previous hydro conditioning was carried out. Storage using Pet® bottles at room temperature for up to 25 days allows seeds viability.


Author(s):  
Henry H. Eichelberger ◽  
John G. Baust ◽  
Robert G. Van Buskirk

For research in cell differentiation and in vitro toxicology it is essential to provide a natural state of cell structure as a benchmark for interpreting results. Hypothermosol (Cryomedical Sciences, Rockville, MD) has proven useful in insuring the viability of synthetic human epidermis during cold-storage and in maintaining the epidermis’ ability to continue to differentiate following warming.Human epidermal equivalent, EpiDerm (MatTek Corporation, Ashland, MA) consisting of fully differentiated stratified human epidermal cells were grown on a microporous membrane. EpiDerm samples were fixed before and after cold-storage (4°C) for 5 days in Hypothermosol or skin culture media (MatTek Corporation) and allowed to recover for 7 days at 37°C. EpiDerm samples were fixed 1 hour in 2.5% glutaraldehyde in sodium cacodylate buffer (pH 7.2). A secondary fixation with 0.2% ruthenium tetroxide (Polysciences, Inc., Warrington, PA) in sodium cacodylate was carried out for 3 hours at 4°C. Other samples were similarly fixed, but with 1% Osmium tetroxide in place of ruthenium tetroxide. Samples were dehydrated through a graded acetone series, infiltrated with Spurrs resin (Polysciences Inc.) and polymerized at 70°C.


Sign in / Sign up

Export Citation Format

Share Document