Young age, female sex, and presence of systemic adverse reactions are associated with high post-vaccination antibody titer after two doses of BNT162b2 mRNA SARS-CoV-2 vaccination: An observational study of 646 Japanese healthcare workers and university staff

AbstractThe purpose of this study was to examine the efficacy rendered with a single dose of live attenuated measles, rubella, mumps, and varicella containing vaccine.We inoculated healthcare workers (HCWs) with a single dose of vaccine to a disease lacking in antibody titer for those not meeting the criteria of our hospital (measles: <16.0 (IgG enzyme immunoassay (EIA)), rubella: ≤1:32 (hemagglutination-inhibition), mumps: <4.0 (IgG EIA), and varicella: <4.0 (IgG EIA)). At 28–60 days after vaccination, the antibody titer was tested again.We included 48 HCWs. A total of 32, 15, 31, and 10 individuals were inoculated with a single dose of measles-containing, rubella-containing, mumps, or varicella vaccine, respectively, and showed significant antibody elevation (9.2 ± 12.3 to 27.6 ± 215.6, p<0.001; 8 ± 1.2 to 32 ± 65.5, p<0.001; 3.0 ± 1.0 to 13.1 ± 8.6, p<0.05; and 2.6 ± 1.3 to 11.8 ± 8.1, p<0.001, respectively). Major side effects were not observed.In a limited population, a single dose of live attenuated vaccine showed elevation of antibody titer without any severe adverse reactions. However, whether the post-vaccination response rate criteria of our university was fulfilled could not be determined owing to limited sample size.

Download Full-text

Prevalence of Adverse Reactions to Different COVID-19 Vaccinations among Karachi Residents

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i47a33023 ◽

2021 ◽

pp. 379-386

Author(s):

Hira Ahmed Malik ◽

Aisha Faraz ◽

Afreen Bhatty ◽

Tayyaba Mumtaz ◽

Urooj Zafar ◽

...

Keyword(s):

Adverse Effects ◽

Observational Study ◽

Muscle Pain ◽

Adverse Reactions ◽

Vaccine Hesitancy ◽

Post Vaccination ◽

Arm Pain

Background: Coronavirus disease 2019 (COVID-19) pandemic emerged in Karachi and rapidly spread throughout Pakistan Since February 26, 2020. Objectives: Vaccination is currently one of the most effective COVID-19 eradication approach. The purpose of this study was to gather data on the adverse effects of the COVID-19 vaccine. Methodology: It was an observational study that was carried out between the 11th and 23rd of April 2021, and the participants were Karachi residents. We looked at the proportion of self-reported local and systemic adverse effects within seven days of immunization in people who filled out Google forms and received one or two doses of the vaccine. Results: The vaccination ratio for male was slight higher than females. Participants aged between 51 to 60 years and 41 to 50 years had higher number of vaccinations. Sinopharm is by far the most widely used vaccine. After the first dose of vaccination, the majority of participants complained of fever, chills, muscle pain, and arm pain, whereas after the second dose, the majority of participants had no symptoms, with a few participants complaining of fever, chills, diarrhea, and muscle pain. Conclusion: The first and second doses' post-vaccination adverse effects were mild and predictable, and there were no hospitalizations; this data can help lessen vaccine hesitancy.

Download Full-text

COVID-19 Exposure Risk for Family Members of Healthcare Workers: An Observational Study

SSRN Electronic Journal ◽

10.2139/ssrn.3622385 ◽

2020 ◽

Author(s):

Lorenzo Dioscoridi ◽

Chiara Carrisi

Keyword(s):

Observational Study ◽

Healthcare Workers ◽

Family Members ◽

Exposure Risk

Download Full-text

Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study

Current Drug Safety ◽

10.2174/1574886314666190122095702 ◽

2019 ◽

Vol 14 (2) ◽

pp. 122-126

Author(s):

Deepti Chopra ◽

Abhinav Jain ◽

Richa Garg ◽

Shreya Dhingra

Keyword(s):

Observational Study ◽

Contrast Media ◽

Adverse Drug Reactions ◽

Teaching Hospital ◽

Adverse Reactions ◽

North India ◽

Drug Reactions ◽

Iodinated Contrast ◽

Radiographic Contrast ◽

Radiographic Contrast Media

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non-ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Methods:An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability was assessed using modified Schumock and Thornton criterion. Results:A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5 (45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported. Conclusion:The reactions observed were mild to moderate in severity and occurred within 30 minutes of the administration of the contrast.

Download Full-text

Tai Chi and workplace wellness for health care workers: a systematic review

European Journal of Public Health ◽

10.1093/eurpub/ckaa166.1375 ◽

2020 ◽

Vol 30 (Supplement_5) ◽

Author(s):

B Dorelli ◽

R A Cocchiara ◽

G Gholamalishahi ◽

W Longo ◽

E Musumeci ◽

...

Keyword(s):

Systematic Review ◽

Case Report ◽

Observational Study ◽

Methodological Quality ◽

Healthcare Workers ◽

Tai Chi ◽

Work Related Stress ◽

Work Related ◽

Positive Effects ◽

Related Stress

Abstract Background Several studies show positive effects of new non-medical therapies known as complementary and alternative medicines, such as the discipline of tai chi. As healthcare professions are among the most vulnerable for work-related stress, this systematic review aims to investigate the relationship between tai chi practice and wellness of healthcare workers. Methods Cinahl, Scopus, Web of Science and PubMed were searched in September 2019. Full-text articles, written in English and published after 1995, were recruited if they focused on positive effects of tai chi on the psychophysical wellbeing of healthcare workers, in comparison with alternative techniques (such as yoga or traditional care). Outcomes were reduced work-related stress, better physical and psychological function, improvement in attention and/or productivity; no restrictions about study design were applied. Quality assessment was performed with the Newcastle-Ottawa Scale on cohort/cross-sectional studies, the Jadad scale for randomized clinical trial, AMSTAR for systematic reviews and CASE REPORT scale for case study. Results 6/111 papers were included: 3 clinical trials, 1 observational study, 1 systematic review and 1 case report. The methodological quality was of medium level. 2/3 trials found a significant increase in individuals' wellbeing and improvements in stress levels and nursing staff’s motivation in their work. In the observational study tai chi was a prevalent mind-body practice to reduce stress. The systematic review suggested that tai chi could be a useful tool to reduce stress-related chronic pain. In case report the effectiveness was observed in medical students. Conclusions This study highlights the full potential and possible beneﬁts derived from tai chi but its application to improve health professionals' wellbeing is still limited, and the absence of a standardized intervention impacts on the methodological quality and reduces the robustness of the retrieved evidence. Key messages Tai chi can improve many pathological conditions and reduce work-related stress. Further research is needed to gain robust evidence of its efficacy for wellbeing of healthcare workers.

Download Full-text

Future Healthcare Workers and Hepatitis B Vaccination: A New Generation

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18157783 ◽

2021 ◽

Vol 18 (15) ◽

pp. 7783

Author(s):

Andrea Trevisan ◽

Paola Mason ◽

Annamaria Nicolli ◽

Stefano Maso ◽

Marco Fonzo ◽

...

Keyword(s):

Hepatitis B ◽

Antibody Titer ◽

Healthcare Workers ◽

Lower Percentage ◽

Hepatitis B Vaccination ◽

High Morbidity ◽

One Year ◽

Mandatory Vaccination ◽

University Of Padua ◽

The University

Before the introduction of universal vaccination, hepatitis B caused high morbidity and mortality, especially among healthcare workers. In the present study, the immune status against hepatitis B was assessed in a cohort of 11,188 students of the degree courses of the School of Medicine of the University of Padua (Italy) who had been subjected to mandatory vaccination in childhood or adolescence and who will be future healthcare workers. The variables that influence the antibody response to vaccination are mainly the age at which the vaccine was administered and sex. If vaccination was administered before one year of age, there is a high probability (around 50%) of having an antibody titer lower than 10 IU/L compared to those vaccinated after one year of age (12.8%). The time between vaccine and analysis is not decisive. Furthermore, female sex, but only if vaccination was administered after one year of age, shows a significant (p = 0.0008) lower percentage of anti-HBs below 10 IU/L and a greater antibody titer (p < 0.0001). In conclusion, the differences related to the age of vaccination induce more doubts than answers. The only plausible hypothesis, in addition to the different immune responses (innate and adaptive), is the type of vaccine. This is not easy to verify because vaccination certificates rarely report it.

Download Full-text

Neutralizing Anti-SARS-CoV-2 Antibody Titer and Reported Adverse Effects, in a Sample of Italian Nursing Home Personnel after Two Doses of the BNT162b2 Vaccine Administered Four Weeks Apart

Vaccines ◽

10.3390/vaccines9060652 ◽

2021 ◽

Vol 9 (6) ◽

pp. 652

Author(s):

Alberto Modenese ◽

Stefania Paduano ◽

Annalisa Bargellini ◽

Rossana Bellucci ◽

Simona Marchetti ◽

...

Keyword(s):

Nursing Home ◽

Adverse Effects ◽

Antibody Titer ◽

Healthcare Workers ◽

Vaccination Campaign ◽

Northern Italy ◽

High Antibody ◽

Protective Level ◽

High Antibody Titer ◽

Main Factors

Background: The immunization of healthcare workers (HCWs) plays a recognized key role in prevention in the COVID-19 pandemic: in Italy, the vaccination campaign began at the end of December 2020. A better knowledge of the on-field immune response in HCWs, of adverse effects and of the main factors involved is fundamental. Methods: We performed a study on workers at a nursing home in Northern Italy, vaccinated in January–February 2021 with two doses of the BNT162b2 vaccine four weeks apart, instead of the three weeks provided for in the original manufacturer protocol. One month after the second dose, the serological titer of IgG-neutralizing anti-RBD antibodies of the subunit S1 of the spike protein of SARS-CoV-2 was determined. The socio-demographic and clinical characteristics of the subjects and adverse effects of vaccination were collected by questionnaire. Results: In all of the workers, high antibody titer, ranging between 20 and 760 times the minimum protective level were observed. Titers were significantly higher in subjects with a previous COVID-19 diagnosis. Adverse effects after the vaccine were more frequent after the second dose, but no severe adverse effects were observed. Conclusions: The two doses of the BNT162b2 vaccine, even if administered four weeks apart, induced high titers of anti-SARS-CoV-2 neutralizing IgG in all the operators included in the study.

Download Full-text