Molecular evidence of ovine (G1) and camel (G6) strains of Echinococcus granulosus in Tunisia and putative role of cattle in human contamination

2005 ◽  
Vol 129 (3-4) ◽  
pp. 267-272 ◽  
Author(s):  
S. M’rad ◽  
D. Filisetti ◽  
M. Oudni ◽  
M. Mekki ◽  
M. Belguith ◽  
...  
Keyword(s):  
Echinococcus Granulosus ◽  
Molecular Evidence ◽  
Putative Role ◽  
Human Contamination

scholarly journals Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 38
Author(s):  
Kyung-Hyun Cho
Keyword(s):  
Antiviral Activity ◽  
High Density ◽  
High Density Lipoproteins ◽  
Potent Antiviral Activity ◽  
Apolipoprotein A ◽  
Putative Role

The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I or other apolipoproteins did not. However, there has been no report to elucidate the putative role of apoA-II in the antiviral activity of HDL.

scholarly journals Aging diminishes the resistance of AO rats to EAE: putative role of enhanced generation of GM-CSF Expressing CD4+ T cells in aged rats

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Zorica Stojić-Vukanić ◽  
Mirjana Nacka-Aleksić ◽  
Ivan Pilipović ◽  
Ivana Vujnović ◽  
Veljko Blagojević ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Aged Rats ◽  
Gm Csf ◽  
Putative Role

scholarly journals Functional Characterization of Spliceosomal Introns and Identification of U2, U4, and U5 snRNAs in the Deep-Branching Eukaryote Entamoeba histolytica

2007 ◽  
Vol 6 (6) ◽  
pp. 940-948 ◽  
Author(s):  
Carrie A. Davis ◽  
Michael P. S. Brown ◽  
Upinder Singh
Keyword(s):  
Entamoeba Histolytica ◽  
Splice Site ◽  
Expressed Sequence Tag ◽  
Functional Characterization ◽  
Molecular Evidence ◽  
Spliceosomal Introns ◽  
Accurate Expression ◽  
Eukaryotic Organisms

ABSTRACT Pre-mRNA splicing is essential to ensure accurate expression of many genes in eukaryotic organisms. In Entamoeba histolytica, a deep-branching eukaryote, approximately 30% of the annotated genes are predicted to contain introns; however, the accuracy of these predictions has not been tested. In this study, we mined an expressed sequence tag (EST) library representing 7% of amoebic genes and found evidence supporting splicing of 60% of the testable intron predictions, the majority of which contain a GUUUGU 5′ splice site and a UAG 3′ splice site. Additionally, we identified several splice site misannotations, evidence for the existence of 30 novel introns in previously annotated genes, and identified novel genes through uncovering their spliced ESTs. Finally, we provided molecular evidence for the E. histolytica U2, U4, and U5 snRNAs. These data lay the foundation for further dissection of the role of RNA processing in E. histolytica gene expression.

Recent insights on the putative role of autophagy in autoimmune diseases

2014 ◽  
Vol 13 (3) ◽  
pp. 231-241 ◽  
Author(s):  
Elena Gianchecchi ◽  
Domenico Vittorio Delfino ◽  
Alessandra Fierabracci
Keyword(s):  
Autoimmune Diseases ◽  
Putative Role

Site-Directed Mutagenesis of a Thermostable α-Amylase from Bacillus stearothermophilus: Putative Role of Three Conserved Residues1

1990 ◽  
Vol 107 (2) ◽  
pp. 267-272 ◽  
Author(s):  
Mauno Vihinen ◽  
Pauli Olikka ◽  
Jukka Niskanen ◽  
Peter Meyer ◽  
IIari Suominen ◽  
...  
Keyword(s):  
Bacillus Stearothermophilus ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Putative Role

scholarly journals Putative role of cytokinin in differential ethylene response of two lines of antisense ACC oxidase cantaloupe melons

2013 ◽  
Vol 86 ◽  
pp. 511-519 ◽  
Author(s):  
Ciane Xavier Gonçalves ◽  
Aline Tiecher ◽  
Fábio Clasen Chaves ◽  
Leonardo Nora ◽  
Li Zhengguo ◽  
...  
Keyword(s):  
Acc Oxidase ◽  
Ethylene Response ◽  
Putative Role

Clinical and molecular evidence for the role of androgens and WT1 in testis descent

2001 ◽  
Vol 185 (1-2) ◽  
pp. 43-50 ◽  
Author(s):  
H.N. Lim ◽  
I.A. Hughes ◽  
J. Ross Hawkins
Keyword(s):  
Molecular Evidence ◽  
Testis Descent

Smith–Magenis syndrome: haploinsufficiency of RAI1 results in altered gene regulation in neurological and metabolic pathways

2011 ◽  
Vol 13 ◽  
Author(s):  
Sarah H. Elsea ◽  
Stephen R. Williams
Keyword(s):  
Metabolic Pathways ◽  
Gene Dosage ◽  
Therapeutic Strategies ◽  
Molecular Evidence ◽  
Diagnostic Strategies ◽  
Functional Studies ◽  
Molecular Features ◽  
Altered Gene ◽  
Behavioural Management

Smith–Magenis syndrome (SMS) is a complex neurobehavioural disorder characterised by intellectual disability, self-injurious behaviours, sleep disturbance, obesity, and craniofacial and skeletal anomalies. Diagnostic strategies are focused towards identification of a 17p11.2 microdeletion encompassing the gene RAI1 (retinoic acid induced 1) or a mutation of RAI1. Molecular evidence shows that most SMS features are due to RAI1 haploinsufficiency, whereas variability and severity are modified by other genes in the 17p11.2 region for 17p11.2 deletion cases. The functional role of RAI1 is not completely understood, but it is probably a transcription factor acting in several different biological pathways that are dysregulated in SMS. Functional studies based on the hypothesis that RAI1 acts through phenotype-specific pathways involving several downstream genes have shown that RAI1 gene dosage is crucial for normal regulation of circadian rhythm, lipid metabolism and neurotransmitter function. Here, we review the clinical and molecular features of SMS and explore more recent studies supporting possible therapeutic strategies for behavioural management.

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