The State of Cost-Utility Analyses in Asia: A Systematic Review

Pancreatic neuroendocrine tumors (PanNETs) are rare tumors having usually an indolent behavior, but sometimes with unpredictable aggressiveness. PanNETs are more often non-functioning (NF), unable to produce functioning hormones, while 10-30% present as functioning (F) - PanNETs, such as insulinomas , gastrinomas , and other rare tumors. Diagnostic and prognostic markers, but also new therapeutic targets, are still lacking. Proteomics techniques represent therefore promising approaches for the future management of PanNETs. We conducted a systematic review to summarize the state of the art of proteomics in PanNETs. A total of 9 studies were included, focusing both on NF- and F-PanNETs. Indeed, proteomics is useful for the diagnosis, the prognosis and the detection of therapeutic targets. However, further studies are required. It is also warranted to standardize the analysis methods and the collection techniques, in order to validate proteins with a relevance in the personalized approach to PanNETs management.

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Telestroke for acute ischaemic stroke: A systematic review of economic evaluations and a de novo cost–utility analysis for a middle income country

Journal of Telemedicine and Telecare ◽

10.1177/1357633x211032407 ◽

2021 ◽

pp. 1357633X2110324

Author(s):

Elise Tan ◽

Lan Gao ◽

Huong NQ Tran ◽

Dominique Cadilhac ◽

Chris Bladin ◽

...

Keyword(s):

Systematic Review ◽

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Rural China ◽

Stroke Care ◽

Cost Utility ◽

Cost Utility Analysis ◽

Sensitivity Analyses ◽

Economic Evaluations ◽

Utility Analysis

Introduction Telemedicine can alleviate the problems faced in rural settings in providing access to specialist stroke care. The evidence of the cost-effectiveness of this model of care outside high-income countries is limited. This study aimed to conduct: (a) a systematic review of economic evaluations of telestroke and (b) a cost–utility analysis of telestroke, using China as a case study. Methods We systematically searched Embase, Medline Complete and Cochrane databases. Inclusion criteria: full economic evaluations of telemedicine/telestroke networks examining the use of thrombolysis in patients with acute ischaemic stroke, published in English. A cost–utility analysis was undertaken using a Markov model incorporating a decision tree to simulate the delivery of telestroke for acute ischaemic stroke in rural China, compared to no telestroke from a societal and healthcare perspective. One-way deterministic sensitivity analyses and probabilistic sensitivity analyses were performed to test the robustness of results. Results Of 559 publications found, eight met the eligibility criteria and were included in the systematic review (two cost-effectiveness analyses and six cost–utility analyses, all performed in high-income countries). Telestroke was a cost-saving/cost-effective intervention in five out of the eight studies. In our modelled analysis for rural China, telestroke was the dominant strategy, with estimated cost savings of Chinese yuan 4,328 (US$627) and additional 0.0925 quality-adjusted life years per patient. Sensitivity analyses confirmed the base case results. Discussion Consistent with published economic evaluations of telestroke in other jurisdictions, telestroke represents a cost-effective solution to enhance stroke care in rural China.

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A Systematic Review of Recommender Systems and Their Applications in Cybersecurity

Sensors ◽

10.3390/s21155248 ◽

2021 ◽

Vol 21 (15) ◽

pp. 5248

Author(s):

Aleksandra Pawlicka ◽

Marek Pawlicki ◽

Rafał Kozik ◽

Ryszard S. Choraś

Keyword(s):

Systematic Review ◽

Recommender Systems ◽

Recommender System ◽

State Of The Art ◽

The State ◽

Advantages And Disadvantages ◽

Comprehensive Survey ◽

Security Concerns ◽

Valuable Role

This paper discusses the valuable role recommender systems may play in cybersecurity. First, a comprehensive presentation of recommender system types is presented, as well as their advantages and disadvantages, possible applications and security concerns. Then, the paper collects and presents the state of the art concerning the use of recommender systems in cybersecurity; both the existing solutions and future ideas are presented. The contribution of this paper is two-fold: to date, to the best of our knowledge, there has been no work collecting the applications of recommenders for cybersecurity. Moreover, this paper attempts to complete a comprehensive survey of recommender types, after noticing that other works usually mention two–three types at once and neglect the others.

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Could Giving Cost-Utility Hta Bodies Negotiating Powers Help Bridge The Gap between Cost-Containment and Broadening Coverage? A Systematic Review of all Swedish Nlt Appraisals of Hospital Pharmaceuticals

Value in Health ◽

10.1016/j.jval.2015.09.1596 ◽

2015 ◽

Vol 18 (7) ◽

pp. A521

Author(s):

R Macaulay

Keyword(s):

Systematic Review ◽

Cost Containment ◽

Cost Utility

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Systematic Review: The State of Research Into Youth Helplines

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1016/j.jaac.2020.12.028 ◽

2020 ◽

Author(s):

Sharna L. Mathieu ◽

Riaz Uddin ◽

Morgan Brady ◽

Samantha Batchelor ◽

Victoria Ross ◽

...

Keyword(s):

Systematic Review ◽

The State ◽

State Of Research

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A systematic review of constructive and solutions journalism research

Journalism ◽

10.1177/14648849211044559 ◽

2021 ◽

pp. 146488492110445

Author(s):

Kyser Lough ◽

Karen McIntyre

Keyword(s):

Systematic Review ◽

The State ◽

Future Research ◽

Academic Activity ◽

Growing Body ◽

The Future ◽

Solutions Journalism ◽

Journalism Research ◽

Constructive Journalism

Academic activity surrounding constructive and solutions journalism has surged in recent years; thus, it is important to pause and reflect on this growing body of work in order to understand where the field can and should go in the future. We conducted a systematic review of existing literature on solutions and constructive journalism ( N = 94), in an effort to (1) describe the state of this field by identifying the patterns and trends in the methodological and conceptual approaches, topics, institutions, countries and practices involved in this research, and (2) illuminate potentially important gaps in the field and suggest recommendations for future research.

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