A Bayesian Nonparametric Approach for Modeling Short-Form 6-Dimension Health State Utility Scores

Background: Typically, modeling of health-related quality of life data is often troublesome since its distribution is positively or negatively skewed, spikes at zero or one, bounded and heteroscedasticity. Objectives: In the present paper, we aim to investigate whether Bayesian beta regression is appropriate for analyzing the SF-6D health state utility scores and respondent characteristics. Methods: A sample of 126 Lebanese members from the American University of Beirut valued 49 health states defined by the SF-6D using the standard gamble technique. Three different models were fitted for SF-6D via Bayesian Markov chain Monte Carlo (MCMC) simulation methods. These comprised a beta regression, random effects and random effects with covariates. Results from applying the three Bayesian beta regression models were reported and compared based on their predictive ability to previously used linear regression models, using mean prediction error (MPE), root mean squared error (RMSE) and deviance information criterion (DIC). Results: For the three different approaches, the beta regression model was found to perform better than the normal regression model under all criteria used. The beta regression with random effects model performs best, with MPE (0.084), RMSE (0.058) and DIC (−1621). Compared to the traditionally linear regression model, the beta regression provided better predictions of observed values in the entire learning sample and in an out-of-sample validation. Conclusions: Beta regression provides a flexible approach to modeling health state values. It also accounted for the boundedness and heteroscedasticity of the SF-6D index scores. Further research is encouraged.

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Finally... Real Utility Scores for Hepatitis C Patients!

Canadian Journal of Gastroenterology ◽

10.1155/2004/746145 ◽

2004 ◽

Vol 18 (6) ◽

pp. 411-412

Author(s):

Kevork M Peltekian

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

The United States ◽

Hcv Infection ◽

Health State Utility ◽

Decompensated Cirrhosis ◽

Health State ◽

Compensated Cirrhosis ◽

Progression Of Disease ◽

Utility Scores

Chong and colleagues (1) used gold-standard methods to assess health-state utilities in 193 outpatients at various stages of liver disease due to chronic hepatitis C (HCV) infection. They showed worsening of health-state utility scores with progression of disease from mild to moderate chronic hepatitis, to compensated cirrhosis, to decompensated cirrhosis and to hepatocellular carcinoma. They also confirmed improvement in health-state utility scores after liver transplantation and with sustained virological response (SVR) to treatment of HCV infection. Patients with HCV infection had lower health-state utility scores than the general Canadian population (PÃ0.001) and significantly poorer quality of life compared with population norms in the United States (PÃ0.005).

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Health state utility scores in advanced non-small cell lung cancer

Lung Cancer ◽

10.1016/j.lungcan.2008.03.019 ◽

2008 ◽

Vol 62 (3) ◽

pp. 374-380 ◽

Cited By ~ 61

Author(s):

Scott Doyle ◽

Andrew Lloyd ◽

Mel Walker

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Health State Utility ◽

Health State ◽

Small Cell Lung ◽

Utility Scores

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Health State Utility Scores for Cancer-Related Anemia through Societal and Patient Valuations

Value in Health ◽

10.1111/j.1524-4733.2008.00394.x ◽

2008 ◽

Vol 11 (7) ◽

pp. 1178-1185 ◽

Cited By ~ 21

Author(s):

Andrew Lloyd ◽

Patricia van Hanswijck de Jonge ◽

Scott Doyle ◽

Paul Cornes

Keyword(s):

Health State Utility ◽

Health State ◽

Cancer Related Anemia ◽

Utility Scores

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Sagittal craniosynostosis: a utility outcomes study

Journal of Neurosurgery Pediatrics ◽

10.3171/2017.2.peds16567 ◽

2017 ◽

Vol 20 (2) ◽

pp. 113-118 ◽

Cited By ~ 3

Author(s):

Victoria Kuta ◽

P. Daniel McNeely ◽

Simon Walling ◽

Michael Bezuhly

Keyword(s):

Online Survey ◽

Assessment Tools ◽

Health State Utility ◽

Health State ◽

Or Education ◽

Health States ◽

Utility Assessment ◽

Objective Health ◽

Sagittal Craniosynostosis ◽

Utility Scores

OBJECTIVESagittal craniosynostosis results in a characteristic scaphocephalic head shape that is typically corrected surgically during a child’s 1st year of life. The authors’ objective was to determine the potential impact of being born with sagittal craniosynostosis by using validated health state utility assessment measures.METHODSAn online utility assessment was designed to generate health utility scores for scaphocephaly, monocular blindness, and binocular blindness using standardized utility assessment tools, namely the visual analog scale (VAS) and the standard gamble (SG) and time trade-off (TTO) tests. Utility scores were compared between health states using the Wilcoxon and Kruskal-Wallis tests. Univariate regression was performed using age, sex, income, and education as independent predictors of utility scores.RESULTSOver a 2-month enrollment period, 122 participants completed the online survey. One hundred eighteen participants were eligible for analysis. Participants rated scaphocephaly due to sagittal craniosynostosis with significantly higher (p < 0.001) median utility scores (VAS 0.85, IQR 0.76–0.95; SG 0.92, IQR 0.84–0.98; TTO 0.91, IQR 0.84–0.95) than both monocular blindness (VAS 0.60, IQR 0.50–0.70; SG 0.84, IQR 0.68–0.94; TTO 0.84, IQR 0.67–0.91) and binocular blindness (VAS 0.25, IQR 0.20–0.40; SG 0.51, IQR 0.18–0.79; TTO 0.55, IQR 0.36–0.76). No differences were noted in utility scores based on participant age, sex, income, or education.CONCLUSIONSUsing objective health state utility scores, authors of the current study demonstrated that the preoperatively perceived burden of scaphocephaly in a child’s 1st year of life is less than that of monocular blindness. These relatively high utility scores for scaphocephaly suggest that the burden of disease as perceived by the general population is low and should inform surgeons’ discussions when offering morbid corrective surgery, particularly when driven by aesthetic concerns.

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PNS93 Analysis of SF-6D Health State Utility Scores: Is Beta Regression Appropriate?

Value in Health ◽

10.1016/j.jval.2021.04.947 ◽

2021 ◽

Vol 24 ◽

pp. S190

Author(s):

S. Kharroubi

Keyword(s):

Health State Utility ◽

Beta Regression ◽

Health State ◽

Utility Scores

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Comparison of the EQ-5D 3L and the SF-6D (SF-36) contemporaneous utility scores in patients with chronic kidney disease in Sri Lanka: a cross-sectional survey

BMJ Open ◽

10.1136/bmjopen-2018-024854 ◽

2019 ◽

Vol 9 (2) ◽

pp. e024854

Author(s):

Sanjeewa Kularatna ◽

Sameera Senanayake ◽

Nalika Gunawardena ◽

Nicholas Graves

Keyword(s):

Chronic Kidney Disease ◽

Sri Lanka ◽

Kidney Disease ◽

Short Form ◽

Classification Systems ◽

Health State ◽

Cross Sectional ◽

Life Years ◽

Sf 36 ◽

Utility Scores

ObjectivesThe aim of this study was to compare utility weights of EuroQoL-five-dimension-3 levels (EQ-5D-3L) and Short-Form six-dimension (SF-6D) in a representative cohort of patients with chronic kidney disease (CKD). A cost–utility analysis (CUA) is designed to report the change to costs required to achieve an estimated change to quality-adjusted life years (QALYs). The quality component of a QALY is measured by utility. Utility represents the preference of general population for a given health state. Classification systems of the multi-attribute utility instruments (MAUIs) are used to define these health states. Utility weights developed from different classification systems can vary and may affect the conclusions from CUAs.DesignA community-based cross-sectional study.SettingAnuradhapura, a rural district in Sri Lanka.ParticipantsA representative sample of 1096 patients with CKD, selected using the population-based CKD register, completed the EQ-5D-3L and SF-36. SF-6D was constructed from the SF-36 according to the published algorithm. The study assessed discrimination, correlation and differences across the two instruments.ResultsStudy participants were predominantly male (62.6%). Mean EQ-5D-3L utility score was 0.540 (SD 0.35) compared with 0.534 (SD 0.09) for the SF-6D (p=0.588). The correlation (r) between the scores was 0.40 (p<0.001). Utility scores were significantly different in both males and females between the two tools, but there was no difference in age and educational categories. Both MAUI scores were significantly lower (p<0.001) among those who were in more advanced stages of the disease and the corresponding utility scores of the two instruments in different CKD stages were also significantly different (p<0.05). The largest effect size was seen among the patients on dialysis.ConclusionsThe correlation between the scores was moderate. SF-6D had the lowest floor and ceiling effect and was better at detecting different stages of the disease. Thus, based on the evidence presented in this study, SF-6D appears to be more appropriate to be used among patients with CKD.

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