scholarly journals Amorphous drug-polymer salt with high stability under tropical conditions and fast dissolution: The challenging case of lumefantrine-PAA

2021 ◽  
Author(s):  
Xin Yao ◽  
Soojin Kim ◽  
Yue Gui ◽  
Zhenxuan Chen ◽  
Junguang Yu ◽  
...  
Keyword(s):  
High Stability ◽  
Tropical Conditions ◽  
Fast Dissolution ◽  
Amorphous Drug

scholarly journals Amorphous Drug–Polymer Salt with High Stability under Tropical Conditions and Fast Dissolution: The Case of Clofazimine and Poly(acrylic acid)

2021 ◽  
Author(s):  
Yue Gui ◽  
Erin C. McCann ◽  
Xin Yao ◽  
Yuhui Li ◽  
Karen J. Jones ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
High Stability ◽  
Tropical Conditions ◽  
Fast Dissolution ◽  
Amorphous Drug ◽  
Poly Acrylic Acid

scholarly journals Amorphous Drug-Polymer Salts

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1271
Author(s):  
Xin Yao ◽  
Amy Lan Neusaenger ◽  
Lian Yu
Keyword(s):  
Recent Progress ◽  
Drug Loading ◽  
Salt Formation ◽  
High Drug ◽  
Coated Particles ◽  
Tropical Conditions ◽  
Amorphous Drugs ◽  
Amorphous Drug ◽  
Future Work ◽  
High Drug Loading

Amorphous formulations provide a general approach to improving the solubility and bioavailability of drugs. Amorphous medicines for global health should resist crystallization under the stressful tropical conditions (high temperature and humidity) and often require high drug loading. We discuss the recent progress in employing drug–polymer salts to meet these goals. Through local salt formation, an ultra-thin polyelectrolyte coating can form on the surface of amorphous drugs, immobilizing interfacial molecules and inhibiting fast crystal growth at the surface. The coated particles show improved wetting and dissolution. By forming an amorphous drug–polymer salt throughout the bulk, stability can be vastly enhanced against crystallization under tropical conditions without sacrificing the dissolution rate. Examples of these approaches are given, along with suggestions for future work.

Amorphous Drug Delivery Systems: Molecular Aspects, Design, and Performance

2004 ◽  
Vol 21 (3) ◽  
pp. 133-193 ◽  
Author(s):  
Aditya Mohan Kaushal ◽  
Piyush Gupta ◽  
Arvind Kumar Bansal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Molecular Aspects ◽  
And Performance ◽  
Amorphous Drug

Delay-Bounded and High Stability Spanning Tree Algorithm for Application Layer Multicast

2011 ◽  
Vol 21 (12) ◽  
pp. 3151-3164 ◽  
Author(s):  
Ji-Jun CAO ◽  
Jin-Shu SU
Keyword(s):  
Spanning Tree ◽  
High Stability ◽  
Application Layer Multicast ◽  
Application Layer ◽  
Tree Algorithm

Comparative study of domestic wastewater treatment efficiencies between facultative pond and water spinach pond

1995 ◽  
Vol 32 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Seni Karnchanawong ◽  
Jaras Sanjitt
Keyword(s):  
Growth Rates ◽  
Domestic Wastewater ◽  
Pilot Scale ◽  
Organic Content ◽  
Water Spinach ◽  
Removal Rates ◽  
Mass Removal ◽  
Loading Rates ◽  
Tropical Conditions ◽  
Average Water

Two pilot-scale studies were comparatively conducted under tropical conditions during December 1992 to September 1993. One study involved facultative ponds(FP) and the others water spinach ponds(SP). Four rectangular concrete ponds, 0.8 m × 2.4 m × 1.1 m (width × length × depth), were employed to treat the Chiang Mai University campus wastewater. Water spinach (Ipomoea aquatica) was planted in two of the ponds. The influent characteristics noted showed a low organic content, i.e. BOD 25.4-29.9 mg/l, with BOD:N ratio around 1:1. The investigations were conducted using the following hydraulic retention times (HRT): 1.6, 2, 2.7, 4, 8 and 16 d. The results showed that the BOD, COD and SS mass removal rates increased as the mass loading rates increased and the SP was significantly more effective in reducing the organic content than the FP. No relationship was found between TN mass removal and the loading rates. However, the TP mass removal rates in the SP and the FP were rather low and were considered to be insignificant. It was observed that SS accumulated in the water spinach root systems which tended to act as a strainer. This process led to plant growth inhibition and finally die-off. The average water spinach growth rates varied from 37 to 107 g wet wt./(m2.d) and no relationship was established between the growth rates and the HRT.

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