scholarly journals Amorphous drug-polymer salt with high stability under tropical conditions and fast dissolution: The challenging case of lumefantrine-PAA

Author(s):  
Xin Yao ◽  
Soojin Kim ◽  
Yue Gui ◽  
Zhenxuan Chen ◽  
Junguang Yu ◽  
...  
Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1271
Author(s):  
Xin Yao ◽  
Amy Lan Neusaenger ◽  
Lian Yu

Amorphous formulations provide a general approach to improving the solubility and bioavailability of drugs. Amorphous medicines for global health should resist crystallization under the stressful tropical conditions (high temperature and humidity) and often require high drug loading. We discuss the recent progress in employing drug–polymer salts to meet these goals. Through local salt formation, an ultra-thin polyelectrolyte coating can form on the surface of amorphous drugs, immobilizing interfacial molecules and inhibiting fast crystal growth at the surface. The coated particles show improved wetting and dissolution. By forming an amorphous drug–polymer salt throughout the bulk, stability can be vastly enhanced against crystallization under tropical conditions without sacrificing the dissolution rate. Examples of these approaches are given, along with suggestions for future work.


1995 ◽  
Vol 32 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Seni Karnchanawong ◽  
Jaras Sanjitt

Two pilot-scale studies were comparatively conducted under tropical conditions during December 1992 to September 1993. One study involved facultative ponds(FP) and the others water spinach ponds(SP). Four rectangular concrete ponds, 0.8 m × 2.4 m × 1.1 m (width × length × depth), were employed to treat the Chiang Mai University campus wastewater. Water spinach (Ipomoea aquatica) was planted in two of the ponds. The influent characteristics noted showed a low organic content, i.e. BOD 25.4-29.9 mg/l, with BOD:N ratio around 1:1. The investigations were conducted using the following hydraulic retention times (HRT): 1.6, 2, 2.7, 4, 8 and 16 d. The results showed that the BOD, COD and SS mass removal rates increased as the mass loading rates increased and the SP was significantly more effective in reducing the organic content than the FP. No relationship was found between TN mass removal and the loading rates. However, the TP mass removal rates in the SP and the FP were rather low and were considered to be insignificant. It was observed that SS accumulated in the water spinach root systems which tended to act as a strainer. This process led to plant growth inhibition and finally die-off. The average water spinach growth rates varied from 37 to 107 g wet wt./(m2.d) and no relationship was established between the growth rates and the HRT.


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