Effects of Running on Sand vs. Stable Ground on Kinetics and Muscle Activities in Individuals With Over-Pronated Feet

Background: In terms of physiological and biomechanical characteristics, over-pronation of the feet has been associated with distinct muscle recruitment patterns and ground reaction forces during running.Objective: The aim of this study was to evaluate the effects of running on sand vs. stable ground on ground-reaction-forces (GRFs) and electromyographic (EMG) activity of lower limb muscles in individuals with over-pronated feet (OPF) compared with healthy controls.Methods: Thirty-three OPF individuals and 33 controls ran at preferred speed and in randomized-order over level-ground and sand. A force-plate was embedded in an 18-m runway to collect GRFs. Muscle activities were recorded using an EMG-system. Data were adjusted for surface-related differences in running speed.Results: Running on sand resulted in lower speed compared with stable ground running (p < 0.001; d = 0.83). Results demonstrated that running on sand produced higher tibialis anterior activity (p = 0.024; d = 0.28). Also, findings indicated larger loading rates (p = 0.004; d = 0.72) and greater vastus medialis (p < 0.001; d = 0.89) and rectus femoris (p = 0.001; d = 0.61) activities in OPF individuals. Controls but not OPF showed significantly lower gluteus-medius activity (p = 0.022; d = 0.63) when running on sand.Conclusion: Running on sand resulted in lower running speed and higher tibialis anterior activity during the loading phase. This may indicate alterations in neuromuscular demands in the distal part of the lower limbs when running on sand. In OPF individuals, higher loading rates together with greater quadriceps activity may constitute a proximal compensatory mechanism for distal surface instability.

Mechanical properties of metal and polymeric viscoelastic materials and their applications

Nowadays, With the wide application of metals and polymeric materials, how to describe the property of Viscoelastic material and how to apply them in engineering has become more and more critical. Due to the lack of insight into the mechanical properties of viscoelastic materials, many scholars have done a lot of experiments in studying the behavior of viscoelastic materials. Axial tensile tests were conducted on specimens to derive different mechanical behaviors of metals, polymers, and other materials at different temperatures and loading rates. Metal can generally be divided into elastic and plastic parts, while polymeric materials have the phases of the linear elastic region, drawing region, and oriented molecular strength region. This paper also shows a test conducted by Argon, Ali S., and M. I. Bessonov of four different kinds of polymers at different circumstances of temperature. After that, the paper shows the application of viscoelastic materials as CLD in damping and some engineering problems caused by the mechanical properties of viscoelastic materials. Currently, research on viscoelasticity should mainly focus on the application of Finite Element Methods and the acquisition of more experimental data to establish a complete theoretical system.

SARS-Cov-2 Delta Variant Decreases Nanobody Binding and ACE2 Blocking Effectivity

The Delta variant spreads more rapidly than previous variants of SARS-CoV-2. This variant comprises several mutations on the receptor-binding domain (RBD_Delta) of its spike (S) glycoprotein, which binds to the peptidase domain (PD) of angiotensin-converting enzyme 2 (ACE2) receptors in host cells. The RBD-PD interaction has been targeted by antibodies and nanobodies to prevent viral infection, but their effectiveness against the Delta variant remains unclear. Here, we investigated RBD_Delta-PD interactions in the presence and absence of nanobodies H11-H4, H11-D4, and Ty1 by performing in a total of 19 µs all-atom molecular dynamics (MD) simulations. Unbiased simulations revealed that Delta variant mutations strengthen RBD binding to ACE2 by increasing the hydrophobic interactions and salt bridge formation, but weaken interactions with H11-H4, H11-D4, and Ty1. Consequently, these nanobodies are unable to dislocate ACE2 from RBD_Delta. Steered MD simulations at comparable loading rates to atomic force microscopy (AFM) experiments estimated lower rupture forces of the nanobodies from RBD_Delta compared to ACE2. Our results suggest that existing nanobodies are less effective to inhibit RBD_Delta-PD interactions and a new generation of nanobodies will be needed to neutralize the Delta variant.

Comparison of the biomechanical parameters during drop jump on compliant and noncompliant surfaces: A new methodological approach

Objective: Bilateral plyometric training of the lower extremities has been shown to provide improvement in vertical force production. However, designing a proper plyometric training program and choosing the appropriate surface is critical, otherwise the risk of injury and lower extremity joint pathologies increases. The aim of this study was to compare biomechanical parameters between mini-trampoline and noncompliant surface during drop jumping. Materials and Methods: Thirty-four male adults participated in the study. Active markers were placed on the left knee, ankle and hip joints of the participants. Also, a force sensing resistor was placed under the participants’ left shoes. During drop jumping, the knee joint angles were recorded by the camera while a data set of reaction forces and loading rates were collected using a force sensing resistor. Data were compared with paired samples T-test. The level of significance was set at p ≤ 0.05. Results: The mean values of maximum reaction forces and loading rates were greater on the noncompliant surface (p < 0.001). Mean knee joint angles for frame at which the knee angle is minimum and the frames one before and one after the frame at which the minimum value is obtained were similar between surfaces, however, were found to be smaller on noncompliant surface for the remaining eight frames (p < 0.05). Conclusion: This study indicates that the range of bending values in the knee joint is greater on noncompliant surface compared to mini-trampoline during drop jump. Since the mini-trampoline resulted in lower reaction forces and loading rates, it can be used as an exercise equipment to minimize the injury risk of plyometric training.