scholarly journals The C. elegans histone deacetylase HDA-1 is required for cell migration and axon pathfinding

2006 ◽  
Vol 289 (1) ◽  
pp. 229-242 ◽  
Author(s):  
Anna Y. Zinovyeva ◽  
Serena M. Graham ◽  
Veronica J. Cloud ◽  
Wayne C. Forrester
Keyword(s):  
Cell Migration ◽  
Histone Deacetylase ◽  
Axon Pathfinding ◽  
C Elegans

scholarly journals Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis

Development ◽  
2001 ◽  
Vol 128 (22) ◽  
pp. 4475-4488 ◽  
Author(s):  
Erik A. Lundquist ◽  
Peter W. Reddien ◽  
Erika Hartwieg ◽  
H. Robert Horvitz ◽  
Cornelia I. Bargmann
Keyword(s):  
Cell Migration ◽  
Axon Guidance ◽  
Apoptotic Cell ◽  
Regulatory Proteins ◽  
Axon Pathfinding ◽  
C Elegans ◽  
Cell Corpse ◽  
And Function ◽  
Redundant Functions ◽  
Caenorhabditis Elegans Genome

The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely required for cell-corpse phagocytosis, and mig-2 and rac-2 have only subtle roles in this process. Rac activators are also used differentially. The UNC-73 Trio Rac GTP exchange factor affected all Rac pathways in axon pathfinding and cell migration but did not affect cell-corpse phagocytosis. CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes.

scholarly journals The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans

Development ◽  
2013 ◽  
Vol 140 (16) ◽  
pp. 3435-3444 ◽  
Author(s):  
M. Doi ◽  
H. Minematsu ◽  
Y. Kubota ◽  
K. Nishiwaki ◽  
M. Miyamoto
Keyword(s):  
Cell Migration ◽  
Neuronal Cell ◽  
The Novel ◽  
Axon Pathfinding ◽  
C Elegans

The novel Rac effector RIN-1 regulates neuronal cell migration and axon pathfinding in C. elegans

2013 ◽  
Vol 126 (16) ◽  
pp. e1-e1
Author(s):  
M. Doi ◽  
H. Minematsu ◽  
Y. Kubota ◽  
K. Nishiwaki ◽  
M. Miyamoto
Keyword(s):  
Cell Migration ◽  
Neuronal Cell ◽  
The Novel ◽  
Axon Pathfinding ◽  
C Elegans

scholarly journals The Actin-Binding Protein UNC-115/abLIM Controls Formation of Lamellipodia and Filopodia and Neuronal Morphogenesis in Caenorhabditis elegans

2005 ◽  
Vol 25 (12) ◽  
pp. 5158-5170 ◽  
Author(s):  
Yieyie Yang ◽  
Erik A. Lundquist
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Mechanisms ◽  
Binding Protein ◽  
Phosphorylation Site ◽  
Serine Phosphorylation ◽  
Actin Binding ◽  
Axon Pathfinding ◽  
Neuronal Morphogenesis ◽  
Actin Binding Protein ◽  
C Elegans

ABSTRACT The roles of actin-binding proteins in development and morphogenesis are not well understood. The actin-binding protein UNC-115 has been implicated in cytoskeletal signaling downstream of Rac in Caenorhabditis elegans axon pathfinding, but the cellular role of UNC-115 in this process remains undefined. Here we report that UNC-115 overactivity in C. elegans neurons promotes the formation of neurites and lamellipodial and filopodial extensions similar to those induced by activated Rac and normally found in C. elegans growth cones. We show that UNC-115 activity in neuronal morphogenesis is enhanced by two molecular mechanisms: when ectopically driven to the plasma membrane by the myristoylation sequence of c-Src, and by mutation of a putative serine phosphorylation site in the actin-binding domain of UNC-115. In support of the hypothesis that UNC-115 modulates actin cytoskeletal organization, we show that UNC-115 activity in serum-starved NIH 3T3 fibroblasts results in the formation of lamellipodia and filopodia. We conclude that UNC-115 is a novel regulator of the formation of lamellipodia and filopodia in neurons, possibly in the growth cone during axon pathfinding.

Plasticity in designing PROTACs for selective and potent degradation of HDAC6

2019 ◽  
Vol 55 (98) ◽  
pp. 14848-14851 ◽  
Author(s):  
Haiyan Yang ◽  
Wenxing Lv ◽  
Ming He ◽  
Haiteng Deng ◽  
Haitao Li ◽  
...  
Keyword(s):  
Cell Migration ◽  
Protein Degradation ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Cellular Processes

HDAC6 (histone deacetylase 6) catalyses the deacetylation of non-histone substrates, and plays important roles in cell migration, protein degradation and other cellular processes.

scholarly journals MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans

2008 ◽  
Vol 105 (52) ◽  
pp. 20804-20809 ◽  
Author(s):  
Y. Kubota ◽  
K. Ohkura ◽  
K. K. Tamai ◽  
K. Nagata ◽  
K. Nishiwaki
Keyword(s):  
Cell Migration ◽  
Basement Membrane ◽  
C Elegans

A normally attractive cell interaction is repulsive in two C. elegans mesodermal cell migration mutants

Development ◽  
1991 ◽  
Vol 113 (3) ◽  
pp. 797-803 ◽  
Author(s):  
M.J. Stern ◽  
H.R. Horvitz
Keyword(s):  
Cell Migration ◽  
Caenorhabditis Elegans ◽  
Premature Termination ◽  
Cell Interaction ◽  
Egg Laying ◽  
Wild Type ◽  
Mesodermal Cell ◽  
C Elegans ◽  
Somatic Gonad ◽  
Sex Myoblasts

In wild-type Caenorhabditis elegans hermaphrodites, two bilaterally symmetric sex myoblasts (SMs) migrate anteriorly to flank the precise center of the gonad, where they divide to generate the muscles required for egg laying (J. E. Sulston and H. R. Horvitz (1977) Devl Biol. 56, 110–156). Although this migration is largely independent of the gonad, a signal from the gonad attracts the SMs to their precise final positions (J. H. Thomas, M. J. Stern and H. R. Horvitz (1990) Cell 62, 1041–1052). Here we show that mutations in either of two genes, egl-15 and egl-17, cause the premature termination of the migrations of the SMs. This incomplete migration is caused by the repulsion of the SMs by the same cells in the somatic gonad that are the source of the attractive signal in wild-type animals.

scholarly journals Molecular signatures of cell migration in C. elegans Q neuroblasts

2009 ◽  
Vol 185 (1) ◽  
pp. 77-85 ◽  
Author(s):  
Guangshuo Ou ◽  
Ronald D. Vale
Keyword(s):  
Cell Migration ◽  
Fluorescent Protein ◽  
Cell Movement ◽  
Live Animal ◽  
Α Subunit ◽  
C Elegans ◽  
Protein Levels ◽  
Neuroblast Migration ◽  
Green Fluorescent

Metazoan cell movement has been studied extensively in vitro, but cell migration in living animals is much less well understood. In this report, we have studied the Caenorhabditis elegans Q neuroblast lineage during larval development, developing live animal imaging methods for following neuroblast migration with single cell resolution. We find that each of the Q descendants migrates at different speeds and for distinct distances. By quantitative green fluorescent protein imaging, we find that Q descendants that migrate faster and longer than their sisters up-regulate protein levels of MIG-2, a Rho family guanosine triphosphatase, and/or down-regulate INA-1, an integrin α subunit, during migration. We also show that Q neuroblasts bearing mutations in either MIG-2 or INA-1 migrate at reduced speeds. The migration defect of the mig-2 mutants, but not ina-1, appears to result from a lack of persistent polarization in the direction of cell migration. Thus, MIG-2 and INA-1 function distinctly to control Q neuroblast migration in living C. elegans.

scholarly journals Histone Deacetylase 7 Silencing Alters Endothelial Cell Migration, a Key Step in Angiogenesis

2007 ◽  
Vol 101 (12) ◽  
pp. 1237-1246 ◽  
Author(s):  
Denis Mottet ◽  
Akeila Bellahcène ◽  
Sophie Pirotte ◽  
David Waltregny ◽  
Christophe Deroanne ◽  
...  
Keyword(s):  
Cell Migration ◽  
Endothelial Cell ◽  
Histone Deacetylase ◽  
Endothelial Cell Migration
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