Cognitive impairment following experimental febrile seizures is determined by sex and seizure duration

2022 ◽  
Vol 126 ◽  
pp. 108430
Author(s):  
Michelle L. Kloc ◽  
Dylan H. Marchand ◽  
Gregory L. Holmes ◽  
Rachel D. Pressman ◽  
Jeremy M. Barry
Keyword(s):  
Cognitive Impairment ◽  
Febrile Seizures ◽  
Seizure Duration

Relationship between Sedative Antihistamines and the Duration of Febrile Seizures

2020 ◽  
Vol 51 (02) ◽  
pp. 154-159
Author(s):  
Atsuro Daida ◽  
Gaku Yamanaka ◽  
Shin-ichi Tsujimoto ◽  
Mina Yokoyama ◽  
Kuniyoshi Hayashi ◽  
...  
Keyword(s):  
Febrile Seizure ◽  
Multivariate Analyses ◽  
Past History ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Seizure Duration ◽  
Cross Sectional ◽  
Prolonged Duration ◽  
History Of ◽  
The Relationship

AbstractSome studies have shown that sedative antihistamines prolong febrile seizure duration. Although the collective evidence is still mixed, the Japanese Society of Child Neurology released guidelines in 2015 that contraindicated the use of sedative antihistamines in patients with febrile seizure. Focused on addressing limitations of previous studies, we conducted a cross-sectional study to evaluate the relationship between febrile seizure duration and the use of sedative antihistamines. Data were collected from patients who visited St. Luke's International Hospital due to febrile seizure between August 2013 and February 2016. Patients were divided into groups based on their prescribed medications: sedative antihistamine, nonsedative antihistamine, and no antihistamine. Seizure duration was the primary outcome and was examined using multivariate analyses. Of the 426 patients included, sedative antihistamines were administered to 24 patients. The median seizure duration was approximately 3 minutes in all three groups. There was no statistical difference in the bivariate (p = 0.422) or multivariate analyses (p = 0.544). Our results do not support the relationship between sedative antihistamine use and prolonged duration of febrile seizure. These results suggest that the use of antihistamines may be considered for patients with past history of febrile seizure, when appropriate.

scholarly journals Glycemic Status in Febrile Seizures

2019 ◽  
Vol 24 (4) ◽  
pp. 58-61
Author(s):  
Raluca Maria Costea ◽  
Ionela Maniu ◽  
Bogdan Neamţu
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Pediatric Population ◽  
Significant Risk ◽  
Febrile Seizures ◽  
Severe Illness ◽  
Seizure Type ◽  
Stress Hyperglycemia ◽  
Seizure Duration

Abstract Stress hyperglycemia is commonly identified in children with severe illness and previously normal glucose homeostasis. In the pediatric population febrile seizures are reported among stress-related conditions associated with stress hyperglycemia. The objective of this prospective study was to evaluate the possible association between blood glucose level and febrile seizure severity defined by fever degree, seizure type, seizure duration and hospitalization length. Among 167 febrile seizures the prevalence of stress hyperglycemia (blood glucose concentration over 150mg/dl) was 13.22%. There was a highly significant statistical association between seizure duration (exceeding 15 minutes) and increased blood glucose concentration (p= 0.001). Prolonged febrile seizures combined with high fever were significant risk factors for stress hyperglycemia. Further analysis on acute fluctuation of glycemia, persistence of hyperglycemia should be taken in consideration as possible prebdictive factor for stress hyperglycemia, by comparison to the peak blood glucose concentration .

scholarly journals Exploring Variances of White Matter Integrity and the Glymphatic System in Simple Febrile Seizures and Epilepsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Mustafa Salimeen Abdelkareem Salimeen ◽  
Congcong Liu ◽  
Xianjun Li ◽  
Miaomiao Wang ◽  
Martha Singh ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Febrile Seizures ◽  
Control Group ◽  
Time Interval ◽  
Control Groups ◽  
Seizure Onset ◽  
Seizure Duration ◽  
Automated Method ◽  
And Control

Background: Simple febrile seizures (SFS) and epilepsy are common seizures in childhood. However, the mechanism underlying SFS is uncertain, and the presence of obvious variances in white matter (WM) integrity and glymphatic function between SFS and epilepsy remain unclear. Therefore, this study aimed to investigate the differences in WM integrity and glymphatic function between SFS and epilepsy.Material and Methods: We retrospectively included 26 children with SFS, 33 children with epilepsy, and 28 controls aged 6–60 months who underwent magnetic resonance imaging (MRI). Tract-based spatial statistics (TBSS) were used to compare the diffusion tensor imaging (DTI) metrics of WM among the above-mentioned groups. T2-weighted imaging (T2WI) was used to segment the visible Virchow-Robin space (VRS) through a custom-designed automated method. VRS counts and volume were quantified and compared among the SFS, epilepsy, and control groups. Correlations of the VRS metrics and seizure duration and VRS metrics and the time interval between seizure onset and MRI scan were also investigated.Results: In comparison with controls, children with SFS showed no significant changes in fractional anisotropy (FA), axial diffusivity (AD), or radial diffusivity (RD) in the WM (P > 0.05). Decreased FA, unchanged AD, and increased RD were observed in the epilepsy group in comparison with the SFS and control groups (P < 0.05). Meanwhile, VRS counts were higher in the SFS and epilepsy groups than in the control group (VRS_SFS, 442.42 ± 74.58, VRS_epilepsy, 629.94 ± 106.55, VRS_control, 354.14 ± 106.58; P < 0.001), and similar results were found for VRS volume (VRS_SFS, 6,228.18 ± 570.74 mm3, VRS_epilepsy, 9,684.84 ± 7,292.66mm3, VRS_control, 4,007.22 ± 118.86 mm3; P < 0.001). However, VRS metrics were lower in the SFS group than in the epilepsy group (P < 0.001). In both SFS and epilepsy, VRS metrics positively correlated with seizure duration and negatively correlated with the course after seizure onset.Conclusion: SFS may not be associated with WM microstructural disruption; however, epilepsy is related to WM alterations. Seizures are associated with glymphatic dysfunction in either SFS or epilepsy.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Toward Identifying Mild Cognitive Impairment in Hispanic and African American Adults

2017 ◽  
Vol 2 (2) ◽  
pp. 110-116
Author(s):  
Valarie B. Fleming ◽  
Joyce L. Harris
Keyword(s):  
Older Adults ◽  
African American ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Healthcare Access ◽  
Communication Disorders ◽  
Healthcare Systems ◽  
Prevention Education ◽  
Education Management ◽  
African American Adults

Across the breadth of acquired neurogenic communication disorders, mild cognitive impairment (MCI) may go undetected, underreported, and untreated. In addition to stigma and distrust of healthcare systems, other barriers contribute to decreased identification, healthcare access, and service utilization for Hispanic and African American adults with MCI. Speech-language pathologists (SLPs) have significant roles in prevention, education, management, and support of older adults, the population must susceptible to MCI.

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