scholarly journals ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary

2011 ◽  
Vol 317 (7) ◽  
pp. 910-919 ◽  
Author(s):  
Johanna Congleton ◽  
Hong Jiang ◽  
Fabio Malavasi ◽  
Hening Lin ◽  
Andrew Yen
Keyword(s):  
Cell Differentiation ◽  
Enzymatic Activity ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Membrane Localization ◽  
Myeloid Leukemia Cell

scholarly journals Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

Blood ◽  
2017 ◽  
Vol 130 (6) ◽  
pp. 732-741 ◽  
Author(s):  
Michael D. Amatangelo ◽  
Lynn Quek ◽  
Alan Shih ◽  
Eytan M. Stein ◽  
Mikhail Roshal ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Myeloid Leukemia ◽  
Response Rate ◽  
Leukemia Cell ◽  
Leukemic Cell ◽  
Ras Pathway ◽  
Mutational Burden ◽  
Key Points ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

Key Points Enasidenib inhibits mIDH2, leading to leukemic cell differentiation with emergence of functional mIDH2 neutrophils in rrAML patients. RAS pathway mutations and increased mutational burden overall are associated with a decreased response rate to mIDH2 inhibition.

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