scholarly journals Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

Blood ◽  
2017 ◽  
Vol 130 (6) ◽  
pp. 732-741 ◽  
Author(s):  
Michael D. Amatangelo ◽  
Lynn Quek ◽  
Alan Shih ◽  
Eytan M. Stein ◽  
Mikhail Roshal ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Myeloid Leukemia ◽  
Response Rate ◽  
Leukemia Cell ◽  
Leukemic Cell ◽  
Ras Pathway ◽  
Mutational Burden ◽  
Key Points ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

Key Points Enasidenib inhibits mIDH2, leading to leukemic cell differentiation with emergence of functional mIDH2 neutrophils in rrAML patients. RAS pathway mutations and increased mutational burden overall are associated with a decreased response rate to mIDH2 inhibition.

scholarly journals PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells

Blood ◽  
2017 ◽  
Vol 129 (18) ◽  
pp. 2493-2506 ◽  
Author(s):  
Cécile Naudin ◽  
Aurore Hattabi ◽  
Fabio Michelet ◽  
Ayda Miri-Nezhad ◽  
Aissa Benyoucef ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Leukemia Cells ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Direct Binding ◽  
Growth Promoting ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

Key Points The RNA regulators PUMILIO sustain HSPC and acute myeloid leukemia cell growth by upregulating FOXP1 expression through direct binding to 2 FOXP1-3′UTR PUMILIO-binding elements. FOXP1 mediates PUMILIO growth-promoting activities by repressing expression of p21CIP1 and p27KIP1cell cycle inhibitors.

scholarly journals Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion

Oncotarget ◽  
2016 ◽  
Vol 7 (47) ◽  
pp. 78095-78109 ◽  
Author(s):  
Xiaohui Si ◽  
Xiaoyun Zhang ◽  
Xing Hao ◽  
Yunan Li ◽  
Zizhen Chen ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Cell Expansion ◽  
Myeloid Leukemia ◽  
Poor Prognosis ◽  
Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell
Sign in / Sign up

Export Citation Format

Share Document