Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5

2021 ◽  
Vol 401 (2) ◽  
pp. 112519
Author(s):  
Dan-Ni Fu ◽  
Yu Wang ◽  
Li-Jun Yu ◽  
Ming-Jie Liu ◽  
Dong Zhen
Keyword(s):  
Dna Damage ◽  
Atherosclerotic Plaque ◽  
Plaque Formation ◽  
Non Coding Rna ◽  
Atherosclerotic Plaque Formation ◽  
Long Non Coding Rna

scholarly journals Therapies Targeted at Non-Coding RNAs in Prevention and Limitation of Myocardial Infarction and Subsequent Cardiac Remodeling—Current Experience and Perspectives

2021 ◽  
Vol 22 (11) ◽  
pp. 5718
Author(s):  
Michal Kowara ◽  
Sonia Borodzicz-Jazdzyk ◽  
Karolina Rybak ◽  
Maciej Kubik ◽  
Agnieszka Cudnoch-Jedrzejewska
Keyword(s):  
Myocardial Infarction ◽  
Atherosclerotic Plaque ◽  
Cardiac Remodeling ◽  
Therapeutic Option ◽  
Circular Rna ◽  
Plaque Progression ◽  
Cardiac Damage ◽  
Non Coding Rna ◽  
Causes Of Mortality ◽  
Long Non Coding Rna

Myocardial infarction is one of the major causes of mortality worldwide and is a main cause of heart failure. This disease appears as a final point of atherosclerotic plaque progression, destabilization, and rupture. As a consequence of cardiomyocytes death during the infarction, the heart undergoes unfavorable cardiac remodeling, which results in its failure. Therefore, therapies aimed to limit the processes of atherosclerotic plaque progression, cardiac damage during the infarction, and subsequent remodeling are urgently warranted. A hopeful therapeutic option for the future medicine is targeting and regulating non-coding RNA (ncRNA), like microRNA, circular RNA (circRNA), or long non-coding RNA (lncRNA). In this review, the approaches targeted at ncRNAs participating in the aforementioned pathophysiological processes involved in myocardial infarction and their outcomes in preclinical studies have been concisely presented.

scholarly journals Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation

2018 ◽  
Vol 38 (11) ◽  
pp. 2562-2575 ◽  
Author(s):  
Petteri Rinne ◽  
Raquel Guillamat-Prats ◽  
Martina Rami ◽  
Laura Bindila ◽  
Larisa Ring ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Plaque Formation ◽  
Macrophage Phenotype ◽  
Atherosclerotic Plaque Formation
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