SENTIREC – The sentinel node mapping in women with cervical cancer study – Patient-reported early lymphedema and its impact on quality of life

IntroductionTo describe patient-reported outcomes and toxicities at time of treatment discontinuation secondary to progression or toxicities in advanced/recurrent cervical cancer patients receiving chemotherapy with bevacizumab.MethodsSummarize toxicity, grade, and health-related quality of life within 1 month of treatment discontinuation for women receiving chemotherapy with bevacizumab in GOG240.ResultsOf the 227 patients who received chemotherapy with bevacizumab, 148 discontinued study protocol treatment (90 for disease progression and 58 for toxicity). The median survival time from treatment discontinuation to death was 7.9 months (95% CI 5.0 to 9.0) for those who progressed versus 12.1 months (95% CI 8.9 to 23.2) for those who discontinued therapy due to toxicities. The most common grade 3 or higher toxicities included hematologic, gastrointestinal, and pain. Some 57% (84/148) of patients completed quality of life assessment within 1 month of treatment discontinuation. Those patients who discontinued treatment due to progression had a mean decline in the FACT-Cx TOI of 3.2 points versus 2.2 in patients who discontinued therapy due to toxicity. This was a 9.9 point greater decline in the FACT-Cx TOI scores than those who discontinued treatment due to progression (95% CI 2.8 to 17.0, p=0.007). The decline in quality of life was due to worsening physical and functional well-being. Those who discontinued treatment due to toxicities had worse neurotoxicity and pain.DiscussionPatients who discontinued chemotherapy with bevacizumab for toxicity experienced longer post-protocol survival but significantly greater declination in quality of life than those with progression. Future trial design should include supportive care interventions that optimize physiologic function and performance status for salvage therapies.

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SP-0128: Patient reported quality of life with IGABT in cervical cancer

Radiotherapy and Oncology ◽

10.1016/s0167-8140(15)40126-4 ◽

2015 ◽

Vol 115 ◽

pp. S60

Author(s):

R.A. Nout ◽

K. Kirchheiner ◽

K. Tanderup ◽

J.C. Lindegaard ◽

R. Pötter

Keyword(s):

Quality Of Life ◽

Cervical Cancer ◽

Patient Reported

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Quality of life (QoL) and patient reported outcome measures (PROMS) in radiologically N0 (rN0) necks treated by Sentinel Node Biopsy (SNB) or Elective Neck Dissection (END)

British Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.bjoms.2015.08.174 ◽

2015 ◽

Vol 53 (10) ◽

pp. e98

Author(s):

C. Schilling ◽

F. Ridout ◽

I. Hutchison ◽

M. McGurk

Keyword(s):

Quality Of Life ◽

Sentinel Node ◽

Neck Dissection ◽

Sentinel Node Biopsy ◽

Patient Reported Outcome Measures ◽

Patient Reported Outcome ◽

Elective Neck Dissection ◽

Node Biopsy ◽

Patient Reported

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PO-0811: Patient-reported quality of life in cervical cancer patients treated with definitive chemoradiation

Radiotherapy and Oncology ◽

10.1016/s0167-8140(18)31121-6 ◽

2018 ◽

Vol 127 ◽

pp. S422-S423

Author(s):

J.L. Conway ◽

S. Felder ◽

J. Tang ◽

A. Fyles ◽

M. Milosevic ◽

...

Keyword(s):

Quality Of Life ◽

Cervical Cancer ◽

Cancer Patients ◽

Definitive Chemoradiation ◽

Patient Reported

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Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical cancer

Clinical & Translational Oncology ◽

10.1007/s12094-021-02632-7 ◽

2021 ◽

Author(s):

K. Baessler ◽

S. Windemut ◽

V. Chiantera ◽

C. Köhler ◽

J. Sehouli

Keyword(s):

Quality Of Life ◽

Cervical Cancer ◽

Minimally Invasive ◽

Pelvic Floor ◽

Radical Hysterectomy ◽

Early Stage ◽

Bowel Function ◽

Patient Reported ◽

Early Stage Cervical Cancer

Abstract Purpose Despite the establishment of radical surgery for therapy of cervical cancer, data on quality of life and patient-reported outcomes are scarce. The aim of this retrospective cohort study was to evaluate bladder, bowel and sexual function in women who underwent minimally invasive surgery for early-stage cervical cancer. Methods From 2007–2013, 261 women underwent laparoscopically assisted radical vaginal hysterectomy (LARVH = 45), vaginally assisted laparoscopic or robotic radical hysterectomy (VALRRH = 61) or laparoscopic total mesometrial resection (TMMR = 25) and 131 of them completed the validated German version of the Australian Pelvic Floor Questionnaire (PFQ). Results were compared with controls recruited from gynecological clinics (n = 24) and with urogynecological patients (n = 63). Results Groups were similar regarding age, BMI and parity. The TMMR group had significantly shorter median follow-up (16 months versus 70 and 36 months). Postoperatively, deterioration of bladder function was reported by 70%, 57% and 44% in the LARVH, VARRVH and TMMR groups, respectively (p = 0.734). Bowel function was significantly worse after TMMR with a higher deterioration rate in 72 versus 43% (LARVH) and 47% (VARRVH) with a correspondingly higher bowel dysfunction score of 2.9 versus 1.5 and 1.8, respectively and 1.8 in urogynaecological patients. Sexual dysfunction was common in all surgical groups. 38% considered their vagina too short which was significantly associated with deep dyspareunia. Compared with controls, surgical groups had significantly increased PFQ scores. Conclusion Pelvic floor dysfunction commonly deteriorates and negatively impacts on quality of life after minimally invasive radical hysterectomy, especially bowel function after TMMR. Pelvic floor symptoms should routinely be addressed pre- and postoperatively.

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QOL-19. THE PROMOTE STUDY: PATIENT REPORTED OUTCOME MEASURES ONLINE TO ENHANCE COMMUNICATION AND QUALITY OF LIFE AFTER CHILDHOOD BRAIN TUMOUR

Neuro-Oncology ◽

10.1093/neuonc/noy059.601 ◽

2018 ◽

Vol 20 (suppl_2) ◽

pp. i161-i161

Author(s):

Kim Bull ◽

Anne-Sophie Darlington ◽

Martha Grootenhuis ◽

Darren Hargrave ◽

Christina Liossi ◽

...

Keyword(s):

Quality Of Life ◽

Brain Tumour ◽

Outcome Measures ◽

Patient Reported Outcome Measures ◽

Patient Reported Outcome ◽

Study Patient ◽

Patient Reported

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Impact of Ospemifene on Quality of Life and Sexual Function in Young Survivors of Cervical Cancer: A Prospective Study

BioMed Research International ◽

10.1155/2017/7513610 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 9

Author(s):

Nicoletta De Rosa ◽

Giada Lavitola ◽

Pierluigi Giampaolino ◽

Ilaria Morra ◽

Carmine Nappi ◽

...

Keyword(s):

Quality Of Life ◽

Cervical Cancer ◽

Prospective Study ◽

Sexual Function ◽

Clinical Signs ◽

Study Patient ◽

Life Questionnaire ◽

European Organization ◽

Significant Difference

Background. Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. Materials and Methods. Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study. Patient underwent 6 months of therapy. At baseline and after 6 months all subjects performed Vaginal Health Index (VHI). The SF and QoL were measured by The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) and the Cervical Cancer Module (CXC-24). Results. After treatment a significant improvement of each parameter of VHI has been demonstrated. Global health status and emotional and social functioning scores improved significantly. On the contrary, general symptoms scales did not show significant difference from baseline data. Sexual activity, sexual vaginal functioning, body image, and sexual enjoyment scores increased significantly. Conclusion. Ospemifene seems to be effective in decreasing the VVA symptoms in CC survivors.

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Association of Physical Morbidity and Health-Related Quality of Life in a Representative Sample of Older German People

European Journal of Health Psychology ◽

10.1027/2512-8442/a000019 ◽

2018 ◽

Vol 25 (4) ◽

pp. 140-151

Author(s):

Markus A. Wirtz ◽

Matthias Morfeld ◽

Elmar Brähler ◽

Andreas Hinz ◽

Heide Glaesmer

Keyword(s):

Quality Of Life ◽

Representative Sample ◽

Short Form ◽

Physical Symptoms ◽

German Population ◽

Health Related Quality ◽

Patient Reported ◽

Related Quality ◽

Health Related

Abstract. The association between health-related quality of life (HRQoL; Short-Form Health Survey-12; SF-12) and patient-reported morbidity-related symptoms measured by the Patient Health Questionnaire-15 (PHQ-15) is analyzed in a representative sample of older people in the general German population. Data from 1,659 people aged 60 to 85 years were obtained. Latent class analysis identified six classes of patients, which optimally categorize clusters of physical symptoms the participants reported: musculoskeletal impairments (39.8%), healthy (25.7%), musculoskeletal and respiratory/cardiac impairments (12.8%), musculoskeletal and respiratory impairments, along with bowel and digestion problems (12.9%), general impairments (4.9%), and general impairments with no bowel and digestion problems (4.8%). The participants’ SF-12 Physical Health Scores (η2 = .39) and their Mental Health Scores (η2 = .28) are highly associated with these latent classes. These associations remain virtually identical after controlling for age. The results provide evidence that profiles of patient-reported physical impairments correspond strongly with reduced HRQoL independently from aging processes.

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